DegronMD

Uniprot ID: Q96RK0

Source protein: Protein capicua homolog

Source gene: CIC

Class: DEG_SPOP_SBC_1

Location: 678:682

E3 ligase: SPOP

DEGRON score: 0.879

ASA_SCORE: 89.94

COIL: 0.964

CONS_SCORE: 0.4538

DSS_SCORE: 0.3943

HELIX: 0.009

FCONS_SCORE: 1.0997

RIG_SCORE: 0.702

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A669V	TCGA-AD-6964	COAD	TCGA	PVSST	DEG_SPOP_SBC_1	0.0833
p.A669V	DO8360	COAD	ICGC	PVSST	DEG_SPOP_SBC_1	0.0833
p.A687T	DO222427	BTCA	ICGC	PVSST	DEG_SPOP_SBC_1	0.1944
p.A687T	DO229544	UTCA	ICGC	PVSST	DEG_SPOP_SBC_1	0.1944
p.A687T	SIDM00083	Glioblastoma	GDSC	PVSST	DEG_SPOP_SBC_1	0.1944
p.A687T	ACH-000273	Brain Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	0.1944
p.N674S	DO223357	CLLE	ICGC	PVSST	DEG_SPOP_SBC_1	0.2222
p.V676L	DO228813	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	0.2778
p.R688Q	DO228271	MALY	ICGC	PVSST	DEG_SPOP_SBC_1	0.1667
p.R688Q	ACH-000806	Lymphoma	CCLE	PVSST	DEG_SPOP_SBC_1	0.1667
p.V684M	DO229234	THCA	ICGC	PVSST	DEG_SPOP_SBC_1	0.2778
p.V672L	SIDM01964	Esophageal Carcinoma	GDSC	PVSST	DEG_SPOP_SBC_1	0.1667
p.P683L	ACH-000131	Non-Cancerous	CCLE	PVSST	DEG_SPOP_SBC_1	0.3056
p.V672M	ACH-000941	Endometrial/Uterine Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	0.1667
p.V672M	ACH-000954	Endometrial/Uterine Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	0.1667
p.K669R	ACH-000978	Endometrial/Uterine Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NKB5	Pecanex-like protein 2	DEG_SPOP_SBC_1	184:188	PVSST	SPOP	0.9588	More...
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	609:613	PVSST	SPOP	0.9925	More...
Q01484	Ankyrin-2	DEG_SPOP_SBC_1	1892:1896	PVSST	SPOP	0.8922	More...
Q3B7T1	Erythroid differentiation-related factor 1	DEG_SPOP_SBC_1	221:225	PVSST	SPOP	0.7254	More...
Q5T890	DNA excision repair protein ERCC-6-like 2	DEG_SPOP_SBC_1	1371:1375	PVSST	SPOP	0.992	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1426:1430	PVSST	SPOP	0.7323	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	214:218	PVSST	SPOP	0.9849	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5349:5353	PVSST	SPOP	0.9376	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5644:5648	PVSST	SPOP	0.9486	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7985:7989	PVSST	SPOP	0.7091	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9158:9162	PVSST	SPOP	0.6521	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9741:9745	PVSST	SPOP	0.9179	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	840:844	PVSST	SPOP	0.7631	More...
Q96AV8	Transcription factor E2F7	DEG_SPOP_SBC_1	767:771	PVSST	SPOP	0.9633	More...
Q96LX7	Coiled-coil domain-containing protein 17	DEG_SPOP_SBC_1	570:574	PVSST	SPOP	0.9596	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	678:682	PVSST	SPOP	0.879	More...
Q99836	Myeloid differentiation primary response protein MyD88	DEG_SPOP_SBC_1	13:17	PVSST	SPOP	0.8946	More...
Q9BXT5	Testis-expressed protein 15	DEG_SPOP_SBC_1	1137:1141	PVSST	SPOP	0.5394	More...
Q9HC35	Echinoderm microtubule-associated protein-like 4	DEG_SPOP_SBC_1	885:889	PVSST	SPOP	0.9985	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	5275:5279	PVSST	SPOP	0.9192	More...
Q9HCD5	Nuclear receptor coactivator 5	DEG_SPOP_SBC_1	527:531	PVSST	SPOP	0.9982	More...
Q9NQC3	Reticulon-4	DEG_SPOP_SBC_1	112:116	PVSST	SPOP	0.9519	More...
Q9UGN4	CMRF35-like molecule 8	DEG_SPOP_SBC_1	150:154	PVSST	SPOP	0.5101	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1348:1352	PVSST	SPOP	0.9986	More...
Q9Y493	Zonadhesin	DEG_SPOP_SBC_1	547:551	PVSST	SPOP	0.9804	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	754:758	PVSST	SPOP	0.8619	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	229:233	PVSST	SPOP	0.6823	More...
P78312	Protein FAM193A	DEG_SPOP_SBC_1	862:866	PVSST	SPOP	0.6848	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSST

Degron related mutations and impact score

Drug responses associated with CIC mutations

All proteins holding degron of PVSST