DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 5644:5648

E3 ligase: SPOP

DEGRON score: 0.9486

ASA_SCORE: 90.72

COIL: 0.9436

CONS_SCORE: 0

DSS_SCORE: 0.6011

HELIX: 0.0128

FCONS_SCORE: 0

RIG_SCORE: 0.5479

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T5640A	TCGA-06-5416	GBM	TCGA	PVSST	DEG_SPOP_SBC_1	0.2222
p.T5640A	DO10880	GBM	ICGC	PVSST	DEG_SPOP_SBC_1	0.2222
p.S5652R	TCGA-43-2581	LUSC	TCGA	PVSST	DEG_SPOP_SBC_1	0.2222
p.S5652R	DO26602	LUSC	ICGC	PVSST	DEG_SPOP_SBC_1	0.2222
p.P5650S	TCGA-AX-A06F	UCEC	TCGA	PVSST	DEG_SPOP_SBC_1	0.2778
p.P5650S	DO41752	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	0.2778
p.P5650S	SIDM01045	Endometrial Carcinoma	GDSC	PVSST	DEG_SPOP_SBC_1	0.2778
p.P5650S	ACH-000978	Endometrial/Uterine Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	0.2778
p.P5650S	EN	endometrium	COSMIC	PVSST	DEG_SPOP_SBC_1	0.2778
p.P5644S	TCGA-C5-A8XH	CESC	TCGA	PVSST	DEG_SPOP_SBC_1	0.6752
p.P5644S	DO49898	CESC	ICGC	PVSST	DEG_SPOP_SBC_1	0.6752
p.L5634M	TCGA-D3-A3C1	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	0.0556
p.L5634M	DO47323	SKCM	ICGC	PVSST	DEG_SPOP_SBC_1	0.0556
p.S5646F	TCGA-D3-A5GN	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	0.7982
p.S5646F	TCGA-EE-A29A	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	0.7982
p.S5646F	TCGA-FW-A3R5	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	0.7982
p.S5646F	TCGA-OD-A75X	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	0.7982
p.S5646F	DO228011	SKCA	ICGC	PVSST	DEG_SPOP_SBC_1	0.7982
p.S5646F	DO229453	SKCA	ICGC	PVSST	DEG_SPOP_SBC_1	0.7982
p.S5646F	DO37416	SKCM	ICGC	PVSST	DEG_SPOP_SBC_1	0.7982
p.S5646F	DO37406	SKCM	ICGC	PVSST	DEG_SPOP_SBC_1	0.7982
p.S5646F	DO47317	SKCM	ICGC	PVSST	DEG_SPOP_SBC_1	0.7982
p.S5646F	DO48601	SKCM	ICGC	PVSST	DEG_SPOP_SBC_1	0.7982
p.S5641F	TCGA-D3-A8GM	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	0.25
p.S5641F	DO50288	SKCM	ICGC	PVSST	DEG_SPOP_SBC_1	0.25
p.S5649L	TCGA-EE-A2MS	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	0.3056
p.S5649L	DO37567	SKCM	ICGC	PVSST	DEG_SPOP_SBC_1	0.3056
p.S5638F	TCGA-FW-A3R5	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	0.1667
p.S5638F	DO37406	SKCM	ICGC	PVSST	DEG_SPOP_SBC_1	0.1667
p.S5641P	TCGA-VQ-A8PO	STAD	TCGA	PVSST	DEG_SPOP_SBC_1	0.25
p.S5641P	DO233882	GACA	ICGC	PVSST	DEG_SPOP_SBC_1	0.25
p.S5641P	DO51773	STAD	ICGC	PVSST	DEG_SPOP_SBC_1	0.25
p.P5654H	DO548	BLCA	ICGC	PVSST	DEG_SPOP_SBC_1	0.1667
p.L5658I	DO229008	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	0.0556
p.P5657S	DO230556	LUSC	ICGC	PVSST	DEG_SPOP_SBC_1	0.0833
p.P5642S	DO220906	MELA	ICGC	PVSST	DEG_SPOP_SBC_1	0.2778
p.SP5641SS	DO220906	MELA	ICGC	PVSST	DEG_SPOP_SBC_1	0
p.P5654L	SIDM01119	Other Solid Cancers	GDSC	PVSST	DEG_SPOP_SBC_1	0.1667
p.P5654L	ACH-000775	Lung Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	0.1667
p.P5654L	NCI-H727	lung	COSMIC	PVSST	DEG_SPOP_SBC_1	0.1667
p.P5657L	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	PVSST	DEG_SPOP_SBC_1	0.0833
p.P5657L	ACH-000675	Lung Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	0.0833
p.P5657L	NCI-H1734	lung	COSMIC	PVSST	DEG_SPOP_SBC_1	0.0833
p.P5637H	SIDM00554	Ovarian Carcinoma	GDSC	PVSST	DEG_SPOP_SBC_1	0.1389
p.P5637H	SIDM01739	Small Cell Lung Carcinoma	GDSC	PVSST	DEG_SPOP_SBC_1	0.1389
p.P5637H	ACH-000297	Lung Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	0.1389
p.P5637H	ACH-000524	Ovarian Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	0.1389
p.P5637H	KURAMOCHI	ovary	COSMIC	PVSST	DEG_SPOP_SBC_1	0.1389
p.P5637T	SIDM01739	Small Cell Lung Carcinoma	GDSC	PVSST	DEG_SPOP_SBC_1	0.1389
p.P5637T	ACH-000297	Lung Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NKB5	Pecanex-like protein 2	DEG_SPOP_SBC_1	184:188	PVSST	SPOP	0.9588	More...
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	609:613	PVSST	SPOP	0.9925	More...
Q01484	Ankyrin-2	DEG_SPOP_SBC_1	1892:1896	PVSST	SPOP	0.8922	More...
Q3B7T1	Erythroid differentiation-related factor 1	DEG_SPOP_SBC_1	221:225	PVSST	SPOP	0.7254	More...
Q5T890	DNA excision repair protein ERCC-6-like 2	DEG_SPOP_SBC_1	1371:1375	PVSST	SPOP	0.992	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1426:1430	PVSST	SPOP	0.7323	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	214:218	PVSST	SPOP	0.9849	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5349:5353	PVSST	SPOP	0.9376	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5644:5648	PVSST	SPOP	0.9486	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7985:7989	PVSST	SPOP	0.7091	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9158:9162	PVSST	SPOP	0.6521	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9741:9745	PVSST	SPOP	0.9179	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	840:844	PVSST	SPOP	0.7631	More...
Q96AV8	Transcription factor E2F7	DEG_SPOP_SBC_1	767:771	PVSST	SPOP	0.9633	More...
Q96LX7	Coiled-coil domain-containing protein 17	DEG_SPOP_SBC_1	570:574	PVSST	SPOP	0.9596	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	678:682	PVSST	SPOP	0.879	More...
Q99836	Myeloid differentiation primary response protein MyD88	DEG_SPOP_SBC_1	13:17	PVSST	SPOP	0.8946	More...
Q9BXT5	Testis-expressed protein 15	DEG_SPOP_SBC_1	1137:1141	PVSST	SPOP	0.5394	More...
Q9HC35	Echinoderm microtubule-associated protein-like 4	DEG_SPOP_SBC_1	885:889	PVSST	SPOP	0.9985	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	5275:5279	PVSST	SPOP	0.9192	More...
Q9HCD5	Nuclear receptor coactivator 5	DEG_SPOP_SBC_1	527:531	PVSST	SPOP	0.9982	More...
Q9NQC3	Reticulon-4	DEG_SPOP_SBC_1	112:116	PVSST	SPOP	0.9519	More...
Q9UGN4	CMRF35-like molecule 8	DEG_SPOP_SBC_1	150:154	PVSST	SPOP	0.5101	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1348:1352	PVSST	SPOP	0.9986	More...
Q9Y493	Zonadhesin	DEG_SPOP_SBC_1	547:551	PVSST	SPOP	0.9804	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	754:758	PVSST	SPOP	0.8619	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	229:233	PVSST	SPOP	0.6823	More...
P78312	Protein FAM193A	DEG_SPOP_SBC_1	862:866	PVSST	SPOP	0.6848	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PVSST