DegronMD

Uniprot ID: Q9Y493

Source protein: Zonadhesin

Source gene: ZAN

Class: DEG_SPOP_SBC_1

Location: 547:551

E3 ligase: SPOP

DEGRON score: 0.9804

ASA_SCORE: 82.82

COIL: 0.9342

CONS_SCORE: 0.3127

DSS_SCORE: 0.5914

HELIX: 0.0188

FCONS_SCORE: 0.8576

RIG_SCORE: 0.6089

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S549F	SIDM00545	Melanoma	GDSC	PVSST	DEG_SPOP_SBC_1	0.7982
p.T551N	TCGA-ND-A4WC	UCS	TCGA	PVSST	DEG_SPOP_SBC_1	0.7055
p.P547S	TCGA-D3-A5GO	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	0.6752
p.P547S	DO47419	SKCM	ICGC	PVSST	DEG_SPOP_SBC_1	0.6752
p.V548I	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PVSST	DEG_SPOP_SBC_1	0.5965
p.V545I	DO48935	PBCA	ICGC	PVSST	DEG_SPOP_SBC_1	0.2778
p.V545I	SIDM01157	Other Solid Cancers	GDSC	PVSST	DEG_SPOP_SBC_1	0.2778
p.P553L	SIDM00140	Melanoma	GDSC	PVSST	DEG_SPOP_SBC_1	0.2778
p.S554C	SIDM00963	Breast Carcinoma	GDSC	PVSST	DEG_SPOP_SBC_1	0.25
p.P543H	DO233115	GACA	ICGC	PVSST	DEG_SPOP_SBC_1	0.2222
p.P543S	SIDM00140	Melanoma	GDSC	PVSST	DEG_SPOP_SBC_1	0.2222
p.P540T	TCGA-EO-A3AY	UCEC	TCGA	PVSST	DEG_SPOP_SBC_1	0.1389
p.P540T	DO43202	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	0.1389
p.G558N	DO222843	MELA	ICGC	PVSST	DEG_SPOP_SBC_1	0.1389
p.V538L	TCGA-68-8250	LUSC	TCGA	PVSST	DEG_SPOP_SBC_1	0.0833
p.V538L	DO26993	LUSC	ICGC	PVSST	DEG_SPOP_SBC_1	0.0833
p.E561K	TCGA-F5-6814	READ	TCGA	PVSST	DEG_SPOP_SBC_1	0.0556
p.E561K	DO36556	READ	ICGC	PVSST	DEG_SPOP_SBC_1	0.0556

Showing 1 to 18 of 18 entries

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Drug responses associated with ZAN mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PVSST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01484	Ankyrin-2	DEG_SPOP_SBC_1	1892:1896	PVSST	SPOP	0.8922	More...
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	609:613	PVSST	SPOP	0.9925	More...
Q9UGN4	CMRF35-like molecule 8	DEG_SPOP_SBC_1	150:154	PVSST	SPOP	0.5101	More...
Q96LX7	Coiled-coil domain-containing protein 17	DEG_SPOP_SBC_1	570:574	PVSST	SPOP	0.9596	More...
Q5T890	DNA excision repair protein ERCC-6-like 2	DEG_SPOP_SBC_1	1371:1375	PVSST	SPOP	0.992	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1348:1352	PVSST	SPOP	0.9986	More...
Q9HC35	Echinoderm microtubule-associated protein-like 4	DEG_SPOP_SBC_1	885:889	PVSST	SPOP	0.9985	More...
Q3B7T1	Erythroid differentiation-related factor 1	DEG_SPOP_SBC_1	221:225	PVSST	SPOP	0.7254	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	754:758	PVSST	SPOP	0.8619	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1426:1430	PVSST	SPOP	0.7323	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	840:844	PVSST	SPOP	0.7631	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5349:5353	PVSST	SPOP	0.9376	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5644:5648	PVSST	SPOP	0.9486	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7985:7989	PVSST	SPOP	0.7091	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9158:9162	PVSST	SPOP	0.6521	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9741:9745	PVSST	SPOP	0.9179	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	5275:5279	PVSST	SPOP	0.9192	More...
Q99836	Myeloid differentiation primary response protein MyD88	DEG_SPOP_SBC_1	13:17	PVSST	SPOP	0.8946	More...
Q9HCD5	Nuclear receptor coactivator 5	DEG_SPOP_SBC_1	527:531	PVSST	SPOP	0.9982	More...
A6NKB5	Pecanex-like protein 2	DEG_SPOP_SBC_1	184:188	PVSST	SPOP	0.9588	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	678:682	PVSST	SPOP	0.879	More...
P78312	Protein FAM193A	DEG_SPOP_SBC_1	862:866	PVSST	SPOP	0.6848	More...
Q9NQC3	Reticulon-4	DEG_SPOP_SBC_1	112:116	PVSST	SPOP	0.9519	More...
Q9BXT5	Testis-expressed protein 15	DEG_SPOP_SBC_1	1137:1141	PVSST	SPOP	0.5394	More...
Q96AV8	Transcription factor E2F7	DEG_SPOP_SBC_1	767:771	PVSST	SPOP	0.9633	More...

Showing 1 to 25 of 28 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSST

Degron related mutations and impact score

Drug responses associated with ZAN mutations

All proteins holding degron of PVSST