DegronMD

Uniprot ID: Q9NQC3

Source protein: Reticulon-4

Source gene: RTN4

Class: DEG_SPOP_SBC_1

Location: 112:116

E3 ligase: SPOP

DEGRON score: 0.9519

ASA_SCORE: 96.22

COIL: 0.9598

CONS_SCORE: 0.5843

DSS_SCORE: 0.6649

HELIX: 0.0174

FCONS_SCORE: 0.9106

RIG_SCORE: 0.5624

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E124K	DO51941	BLCA	ICGC	PVSST	DEG_SPOP_SBC_1	0.5556
p.E126D	DO230313	COCA	ICGC	PVSST	DEG_SPOP_SBC_1	0.0556
p.E126D	DO41020	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	0.0556
p.E126D	DO41458	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	0.0556
p.D125V	DO229010	COCA	ICGC	PVSST	DEG_SPOP_SBC_1	0.0833
p.D125V	DO230659	LAML	ICGC	PVSST	DEG_SPOP_SBC_1	0.0833
p.D125V	DO231140	LAML	ICGC	PVSST	DEG_SPOP_SBC_1	0.0833
p.R104Q	DO50970	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	0.1111
p.K120E	DO22990	LIHC	ICGC	PVSST	DEG_SPOP_SBC_1	0.2222
p.A126P	DO46366	OV	ICGC	PVSST	DEG_SPOP_SBC_1	0.0556
p.K120Q	DO36556	READ	ICGC	PVSST	DEG_SPOP_SBC_1	0.2222
p.N112H	DO40884	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	0.7423
p.P115S	DO41211	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	0.6752
p.R114K	ACH-000983	Leukemia	CCLE	PVSST	DEG_SPOP_SBC_1	0.7237
p.R114K	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PVSST	DEG_SPOP_SBC_1	0.7237

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NKB5	Pecanex-like protein 2	DEG_SPOP_SBC_1	184:188	PVSST	SPOP	0.9588	More...
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	609:613	PVSST	SPOP	0.9925	More...
Q01484	Ankyrin-2	DEG_SPOP_SBC_1	1892:1896	PVSST	SPOP	0.8922	More...
Q3B7T1	Erythroid differentiation-related factor 1	DEG_SPOP_SBC_1	221:225	PVSST	SPOP	0.7254	More...
Q5T890	DNA excision repair protein ERCC-6-like 2	DEG_SPOP_SBC_1	1371:1375	PVSST	SPOP	0.992	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1426:1430	PVSST	SPOP	0.7323	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	214:218	PVSST	SPOP	0.9849	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5349:5353	PVSST	SPOP	0.9376	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5644:5648	PVSST	SPOP	0.9486	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7985:7989	PVSST	SPOP	0.7091	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9158:9162	PVSST	SPOP	0.6521	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9741:9745	PVSST	SPOP	0.9179	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	840:844	PVSST	SPOP	0.7631	More...
Q96AV8	Transcription factor E2F7	DEG_SPOP_SBC_1	767:771	PVSST	SPOP	0.9633	More...
Q96LX7	Coiled-coil domain-containing protein 17	DEG_SPOP_SBC_1	570:574	PVSST	SPOP	0.9596	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	678:682	PVSST	SPOP	0.879	More...
Q99836	Myeloid differentiation primary response protein MyD88	DEG_SPOP_SBC_1	13:17	PVSST	SPOP	0.8946	More...
Q9BXT5	Testis-expressed protein 15	DEG_SPOP_SBC_1	1137:1141	PVSST	SPOP	0.5394	More...
Q9HC35	Echinoderm microtubule-associated protein-like 4	DEG_SPOP_SBC_1	885:889	PVSST	SPOP	0.9985	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	5275:5279	PVSST	SPOP	0.9192	More...
Q9HCD5	Nuclear receptor coactivator 5	DEG_SPOP_SBC_1	527:531	PVSST	SPOP	0.9982	More...
Q9NQC3	Reticulon-4	DEG_SPOP_SBC_1	112:116	PVSST	SPOP	0.9519	More...
Q9UGN4	CMRF35-like molecule 8	DEG_SPOP_SBC_1	150:154	PVSST	SPOP	0.5101	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1348:1352	PVSST	SPOP	0.9986	More...
Q9Y493	Zonadhesin	DEG_SPOP_SBC_1	547:551	PVSST	SPOP	0.9804	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	754:758	PVSST	SPOP	0.8619	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	229:233	PVSST	SPOP	0.6823	More...
P78312	Protein FAM193A	DEG_SPOP_SBC_1	862:866	PVSST	SPOP	0.6848	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSST

Degron related mutations and impact score

Drug responses associated with RTN4 mutations

All proteins holding degron of PVSST