DegronMD - Q8NDV7(TNRC6A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P358Q	TCGA-09-2044	OV	TCGA	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1667
p.P358Q	DO28923	OV	ICGC	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1667
p.G355R	TCGA-13-0807	OV	TCGA	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.25
p.G355R	DO28206	OV	ICGC	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.25
p.G1061V	TCGA-24-1435	OV	TCGA	PSTPATT	DEG_SCF_FBW7_1	1067:1073	Mutation rewiring degron network	0.1667
p.G1061V	DO31370	OV	ICGC	PSTPATT	DEG_SCF_FBW7_1	1067:1073	Mutation rewiring degron network	0.1667
p.S359C	TCGA-75-5126	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1389
p.S359C	DO23711	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1389
p.S1106C	TCGA-75-6214	LUAD	TCGA	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.1944
p.S1106C	DO24830	LUAD	ICGC	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.1944
p.G1930C	TCGA-86-7955	LUAD	TCGA	LWGTPHYS	DEG_SCF_FBW7_1	1918:1925	Mutation rewiring degron network	0.1944
p.G1930C	TCGA-86-7955	LUAD	TCGA	PPSSS	DEG_SPOP_SBC_1	1931:1935	Mutation rewiring degron network	0.3056
p.G1930C	DO23612	LUAD	ICGC	LWGTPHYS	DEG_SCF_FBW7_1	1918:1925	Mutation rewiring degron network	0.1944
p.G1930C	DO23612	LUAD	ICGC	PPSSS	DEG_SPOP_SBC_1	1931:1935	Mutation rewiring degron network	0.3056
p.S299I	TCGA-86-8073	LUAD	TCGA	VGSSS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.7341
p.S299I	DO23624	LUAD	ICGC	VGSSS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.7341
p.R1677C	TCGA-A5-A0G2	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	1684:1688	Mutation rewiring degron network	0.1389
p.R1677C	TCGA-AZ-4315	COAD	TCGA	PLSST	DEG_SPOP_SBC_1	1684:1688	Mutation rewiring degron network	0.1389
p.R1677C	DO8842	COAD	ICGC	PLSST	DEG_SPOP_SBC_1	1684:1688	Mutation rewiring degron network	0.1389
p.R1677C	DO41235	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	1684:1688	Mutation rewiring degron network	0.1389
p.R1938Q	TCGA-A5-A0G2	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	1931:1935	Mutation rewiring degron network	0.25
p.R1938Q	TCGA-AX-A2H4	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	1931:1935	Mutation rewiring degron network	0.25
p.R1938Q	DO41235	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	1931:1935	Mutation rewiring degron network	0.25
p.R1938Q	DO41193	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	1931:1935	Mutation rewiring degron network	0.25
p.E1093D	TCGA-AA-3966	COAD	TCGA	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.2222
p.E1093D	DO10068	COAD	ICGC	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.2222
p.S350Y	TCGA-AA-A00N	COAD	TCGA	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.712
p.S350Y	DO9876	COAD	ICGC	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.712
p.S350Y	SIDM00193	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.712
p.S350Y	ACH-000991	Colon/Colorectal Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.712
p.S350Y	SNU-81	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.712
p.S299G	TCGA-AA-A022	COAD	TCGA	VGSSS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.6993
p.S299G	DO10647	COAD	ICGC	VGSSS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.6993
p.D1075H	TCGA-AC-A23H	BRCA	TCGA	PSTPATT	DEG_SCF_FBW7_1	1067:1073	Mutation rewiring degron network	0.2778
p.D1075H	DO2401	BRCA	ICGC	PSTPATT	DEG_SCF_FBW7_1	1067:1073	Mutation rewiring degron network	0.2778
p.A344D	TCGA-AG-3906	READ	TCGA	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.2222
p.A344D	DO36491	READ	ICGC	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.2222
p.T1921I	TCGA-AG-A002	READ	TCGA	LWGTPHYS	DEG_SCF_FBW7_1	1918:1925	Mutation altering degron motif	0.7078
p.N224I	TCGA-BA-6868	HNSC	TCGA	PVSST	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.1667
p.N224I	DO14184	HNSC	ICGC	PVSST	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.1667
p.P1067L	TCGA-BF-A3DM	SKCM	TCGA	PSTPATT	DEG_SCF_FBW7_1	1067:1073	Mutation altering degron motif	0.6471
p.P1067L	DO48667	SKCM	ICGC	PSTPATT	DEG_SCF_FBW7_1	1067:1073	Mutation altering degron motif	0.6471
p.T347S	TCGA-BG-A0VW	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.3056
p.T347S	DO40843	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.3056
p.V1683I	TCGA-BS-A0UV	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	1684:1688	Mutation rewiring degron network	0.3056
p.V1683I	TCGA-BS-A0UV	UCEC	TCGA	AQSTS	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.V1683I	DO230342	COCA	ICGC	PLSST	DEG_SPOP_SBC_1	1684:1688	Mutation rewiring degron network	0.3056
p.V1683I	DO230342	COCA	ICGC	AQSTS	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.V1683I	DO42793	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	1684:1688	Mutation rewiring degron network	0.3056
p.V1683I	DO42793	UCEC	ICGC	AQSTS	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.R1345Q	TCGA-CR-7364	HNSC	TCGA	PLSSS	DEG_SPOP_SBC_1	1354:1358	Mutation rewiring degron network	0.0833
p.R1345Q	DO15679	HNSC	ICGC	PLSSS	DEG_SPOP_SBC_1	1354:1358	Mutation rewiring degron network	0.0833
p.W345S	TCGA-CR-7370	HNSC	TCGA	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.25
p.W345S	DO14426	HNSC	ICGC	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.25
p.P358S	TCGA-D7-6818	STAD	TCGA	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1667
p.P358S	TCGA-FS-A1ZZ	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1667
p.P358S	DO37412	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1667
p.P358S	DO38262	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1667
p.W1081R	TCGA-DF-A2KU	UCEC	TCGA	PSTPATT	DEG_SCF_FBW7_1	1067:1073	Mutation rewiring degron network	0.1111
p.W1081R	DO223286	UCEC	ICGC	PSTPATT	DEG_SCF_FBW7_1	1067:1073	Mutation rewiring degron network	0.1111
p.G311W	TCGA-DX-AB3C	SARC	TCGA	VGSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.0556
p.G311W	DO220114	SARC	ICGC	VGSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.0556
p.L1928M	TCGA-EA-A3HU	CESC	TCGA	LWGTPHYS	DEG_SCF_FBW7_1	1918:1925	Mutation rewiring degron network	0.25
p.L1928M	TCGA-EA-A3HU	CESC	TCGA	PPSSS	DEG_SPOP_SBC_1	1931:1935	Mutation rewiring degron network	0.25
p.L1928M	DO6320	CESC	ICGC	LWGTPHYS	DEG_SCF_FBW7_1	1918:1925	Mutation rewiring degron network	0.25
p.L1928M	DO6320	CESC	ICGC	PPSSS	DEG_SPOP_SBC_1	1931:1935	Mutation rewiring degron network	0.25
p.D1936N	TCGA-F7-A624	HNSC	TCGA	PPSSS	DEG_SPOP_SBC_1	1931:1935	Mutation rewiring degron network	0.3056
p.D1936N	TCGA-FP-A4BE	STAD	TCGA	PPSSS	DEG_SPOP_SBC_1	1931:1935	Mutation rewiring degron network	0.3056
p.D1936N	DO44440	HNSC	ICGC	PPSSS	DEG_SPOP_SBC_1	1931:1935	Mutation rewiring degron network	0.3056
p.D1936N	DO48016	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	1931:1935	Mutation rewiring degron network	0.3056
p.Q1353E	TCGA-IN-A6RL	STAD	TCGA	PLSSS	DEG_SPOP_SBC_1	1354:1358	Mutation rewiring degron network	0.3056
p.Q1353E	DO51738	STAD	ICGC	PLSSS	DEG_SPOP_SBC_1	1354:1358	Mutation rewiring degron network	0.3056
p.K294R	TCGA-R6-A6L4	ESCA	TCGA	VGSSS	DEG_SPOP_SBC_1	297:301	Mutation substituting flanking lysine	0.3611
p.N340Y	TCGA-UZ-A9Q1	KIRP	TCGA	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1111
p.N340Y	DO219716	KIRP	ICGC	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1111
p.T1692A	DO222817	BTCA	ICGC	AQSTS	DEG_SPOP_SBC_1	1689:1693	Mutation altering degron motif	0.7139
p.P1943T	DO234320	ESAD	ICGC	PPSSS	DEG_SPOP_SBC_1	1931:1935	Mutation rewiring degron network	0.1111
p.G1105D	DO234356	ESAD	ICGC	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.2222
p.R212W	DO233088	GACA	ICGC	PVSST	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.2778
p.R1677H	DO233764	GACA	ICGC	PLSST	DEG_SPOP_SBC_1	1684:1688	Mutation rewiring degron network	0.1389
p.H1923Y	DO233865	GACA	ICGC	LWGTPHYS	DEG_SCF_FBW7_1	1918:1925	Mutation altering degron motif	0.6118
p.D1075Y	DO231986	LICA	ICGC	PSTPATT	DEG_SCF_FBW7_1	1067:1073	Mutation rewiring degron network	0.2778
p.R1677L	DO229028	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	1684:1688	Mutation rewiring degron network	0.1389
p.S1107I	DO229028	LICA	ICGC	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.1667
p.Q1359H	DO229036	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	1354:1358	Mutation rewiring degron network	0.3056
p.P1931L	DO229036	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	1931:1935	Mutation altering degron motif	0.7582
p.G1110C	DO229037	LICA	ICGC	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.0833
p.G1082V	DO229037	LICA	ICGC	PSTPATT	DEG_SCF_FBW7_1	1067:1073	Mutation rewiring degron network	0.0833
p.G1105V	DO229006	LICA	ICGC	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.2222
p.G1082D	DO50970	LICA	ICGC	PSTPATT	DEG_SCF_FBW7_1	1067:1073	Mutation rewiring degron network	0.0833
p.P1684L	DO23551	LIRI	ICGC	PLSST	DEG_SPOP_SBC_1	1684:1688	Mutation altering degron motif	0.7582
p.P1684L	SIDM00545	Melanoma	GDSC	PLSST	DEG_SPOP_SBC_1	1684:1688	Mutation altering degron motif	0.7582
p.P1684L	ACH-000987	Skin Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	1684:1688	Mutation altering degron motif	0.7582
p.P1684L	Mewo	skin	COSMIC	PLSST	DEG_SPOP_SBC_1	1684:1688	Mutation altering degron motif	0.7582
p.A1071V	DO229177	LMS	ICGC	PSTPATT	DEG_SCF_FBW7_1	1067:1073	Mutation altering degron motif	0.5825
p.G346A	DO221126	MALY	ICGC	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.2778
p.A1678V	DO222843	MELA	ICGC	PLSST	DEG_SPOP_SBC_1	1684:1688	Mutation rewiring degron network	0.1667
p.P214H	DO232224	PBCA	ICGC	PVSST	DEG_SPOP_SBC_1	214:218	Mutation altering degron motif	0.7694
p.E1066V	SIDM00499	Prostate Carcinoma	GDSC	PSTPATT	DEG_SCF_FBW7_1	1067:1073	Mutation rewiring degron network	0.3056
p.E1066V	ACH-000956	Prostate Cancer	CCLE	PSTPATT	DEG_SCF_FBW7_1	1067:1073	Mutation rewiring degron network	0.3056
p.E1066V	22RV1	prostate	COSMIC	PSTPATT	DEG_SCF_FBW7_1	1067:1073	Mutation rewiring degron network	0.3056
p.T1908A	SIDM00845	Burkitt's Lymphoma	GDSC	LWGTPHYS	DEG_SCF_FBW7_1	1918:1925	Mutation rewiring degron network	0.0556
p.T1908A	SIDM00461	Acute Myeloid Leukemia	GDSC	LWGTPHYS	DEG_SCF_FBW7_1	1918:1925	Mutation rewiring degron network	0.0556
p.T1908A	SIDM01519	Head and Neck Carcinoma	GDSC	LWGTPHYS	DEG_SCF_FBW7_1	1918:1925	Mutation rewiring degron network	0.0556
p.T1908A	ACH-000786	Lymphoma	CCLE	LWGTPHYS	DEG_SCF_FBW7_1	1918:1925	Mutation rewiring degron network	0.0556
p.T1908A	Daudi	haematopoietic and lymphoid tissue	COSMIC	LWGTPHYS	DEG_SCF_FBW7_1	1918:1925	Mutation rewiring degron network	0.0556
p.T1908A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	LWGTPHYS	DEG_SCF_FBW7_1	1918:1925	Mutation rewiring degron network	0.0556
p.T1908A	DND-41	haematopoietic and lymphoid tissue	COSMIC	LWGTPHYS	DEG_SCF_FBW7_1	1918:1925	Mutation rewiring degron network	0.0556
p.S1107N	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.1667
p.S1107N	ACH-000789	Lung Cancer	CCLE	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.1667
p.S1107N	NCI-H810	lung	COSMIC	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.1667
p.A1097V	SIDM01248	Thyroid Gland Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation altering degron motif	0.5825
p.A1097V	SIDM01045	Endometrial Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation altering degron motif	0.5825
p.A1097V	SIDM01167	Thyroid Gland Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation altering degron motif	0.5825
p.A1097V	ACH-000163	Thyroid Cancer	CCLE	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation altering degron motif	0.5825
p.A1097V	ACH-000978	Endometrial/Uterine Cancer	CCLE	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation altering degron motif	0.5825
p.A1097V	ACH-001023	Thyroid Cancer	CCLE	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation altering degron motif	0.5825
p.A1097V	CGTH-W-1	thyroid	COSMIC	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation altering degron motif	0.5825
p.A1097V	EN	endometrium	COSMIC	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation altering degron motif	0.5825
p.S1358C	SIDM00602	Gastric Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	1354:1358	Mutation altering degron motif	0.7541
p.S1358C	SIDM00655	Other Solid Cancers	GDSC	PLSSS	DEG_SPOP_SBC_1	1354:1358	Mutation altering degron motif	0.7541
p.S1358C	ACH-000919	Gastric Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	1354:1358	Mutation altering degron motif	0.7541
p.S1358C	ACH-001578	Embryonal Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	1354:1358	Mutation altering degron motif	0.7541
p.S1358C	IM-95	stomach	COSMIC	PLSSS	DEG_SPOP_SBC_1	1354:1358	Mutation altering degron motif	0.7541
p.S1358C	NCCIT	testis	COSMIC	PLSSS	DEG_SPOP_SBC_1	1354:1358	Mutation altering degron motif	0.7541
p.L1362F	SIDM00995	Other Solid Cancers	GDSC	PLSSS	DEG_SPOP_SBC_1	1354:1358	Mutation rewiring degron network	0.2222
p.L1362F	ACH-001328	Skin Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	1354:1358	Mutation rewiring degron network	0.2222
p.L1362F	A431	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	1354:1358	Mutation rewiring degron network	0.2222
p.N224D	SIDM00888	Other Solid Cancers	GDSC	PVSST	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.1667
p.P1089S	SIDM00498	Colorectal Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.1111
p.P1089S	ACH-000970	Colon/Colorectal Cancer	CCLE	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.1111
p.P1089S	SNU-C5	large intestine	COSMIC	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.1111
p.N340S	SIDM00892	Breast Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1111
p.S1107R	SIDM00618	Hepatocellular Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.1667
p.S1107R	ACH-000620	Liver Cancer	CCLE	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.1667
p.S1107R	ACH-001610	Brain Cancer	CCLE	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.1667
p.S1107R	JHH-1	liver	COSMIC	AASST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.1667
p.T287A	SIDM01074	Glioblastoma	GDSC	VGSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.0556
p.N303T	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.2778
p.S1941C	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	1931:1935	Mutation rewiring degron network	0.1667
p.S1941C	ACH-000891	Lung Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	1931:1935	Mutation rewiring degron network	0.1667
p.T1679A	CCK-81	large intestine	COSMIC	PLSST	DEG_SPOP_SBC_1	1684:1688	Mutation rewiring degron network	0.1944
p.T1679A	CCK-81	large intestine	COSMIC	AQSTS	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.0556
p.P1675S	22RV1	prostate	COSMIC	PLSST	DEG_SPOP_SBC_1	1684:1688	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNRC6A

UniProt ID: Q8NDV7

Entrez ID: 27327

Protein name: Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNRC6A in