DegronMD

Uniprot ID: Q8NDV7

Source protein: Trinucleotide repeat-containing gene 6A protein

Source gene: TNRC6A

Class: DEG_SCF_FBW7_1

Location: 1067:1073

E3 ligase: FBXW7

DEGRON score: 0.9826

ASA_SCORE: 79.9714

COIL: 0.9209

CONS_SCORE: 0.258

DSS_SCORE: 0.679

HELIX: 0.0276

FCONS_SCORE: 0.8186

RIG_SCORE: 0.6675

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1061V	TCGA-24-1435	OV	TCGA	PSTPATT	DEG_SCF_FBW7_1	0.1667
p.G1061V	DO31370	OV	ICGC	PSTPATT	DEG_SCF_FBW7_1	0.1667
p.D1075H	TCGA-AC-A23H	BRCA	TCGA	PSTPATT	DEG_SCF_FBW7_1	0.2778
p.D1075H	DO2401	BRCA	ICGC	PSTPATT	DEG_SCF_FBW7_1	0.2778
p.P1067L	TCGA-BF-A3DM	SKCM	TCGA	PSTPATT	DEG_SCF_FBW7_1	0.6471
p.P1067L	DO48667	SKCM	ICGC	PSTPATT	DEG_SCF_FBW7_1	0.6471
p.W1081R	TCGA-DF-A2KU	UCEC	TCGA	PSTPATT	DEG_SCF_FBW7_1	0.1111
p.W1081R	DO223286	UCEC	ICGC	PSTPATT	DEG_SCF_FBW7_1	0.1111
p.D1075Y	DO231986	LICA	ICGC	PSTPATT	DEG_SCF_FBW7_1	0.2778
p.G1082V	DO229037	LICA	ICGC	PSTPATT	DEG_SCF_FBW7_1	0.0833
p.G1082D	DO50970	LICA	ICGC	PSTPATT	DEG_SCF_FBW7_1	0.0833
p.A1071V	DO229177	LMS	ICGC	PSTPATT	DEG_SCF_FBW7_1	0.5825
p.E1066V	SIDM00499	Prostate Carcinoma	GDSC	PSTPATT	DEG_SCF_FBW7_1	0.3056
p.E1066V	ACH-000956	Prostate Cancer	CCLE	PSTPATT	DEG_SCF_FBW7_1	0.3056
p.E1066V	22RV1	prostate	COSMIC	PSTPATT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SCF_FBW7_1	1067:1073	PSTPATT	FBXW7	0.9826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons