DegronMD

Uniprot ID: Q8NDV7

Source protein: Trinucleotide repeat-containing gene 6A protein

Source gene: TNRC6A

Class: DEG_SCF_FBW7_1

Location: 1918:1925

E3 ligase: FBXW7

DEGRON score: 0.9808

ASA_SCORE: 52.5125

COIL: 0.8445

CONS_SCORE: 0.4253

DSS_SCORE: 0.3329

HELIX: 0.0583

FCONS_SCORE: 0.9534

RIG_SCORE: 0.7182

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1930C	TCGA-86-7955	LUAD	TCGA	LWGTPHYS	DEG_SCF_FBW7_1	0.1944
p.G1930C	DO23612	LUAD	ICGC	LWGTPHYS	DEG_SCF_FBW7_1	0.1944
p.T1921I	TCGA-AG-A002	READ	TCGA	LWGTPHYS	DEG_SCF_FBW7_1	0.7078
p.L1928M	TCGA-EA-A3HU	CESC	TCGA	LWGTPHYS	DEG_SCF_FBW7_1	0.25
p.L1928M	DO6320	CESC	ICGC	LWGTPHYS	DEG_SCF_FBW7_1	0.25
p.H1923Y	DO233865	GACA	ICGC	LWGTPHYS	DEG_SCF_FBW7_1	0.6118
p.T1908A	SIDM00845	Burkitt's Lymphoma	GDSC	LWGTPHYS	DEG_SCF_FBW7_1	0.0556
p.T1908A	SIDM00461	Acute Myeloid Leukemia	GDSC	LWGTPHYS	DEG_SCF_FBW7_1	0.0556
p.T1908A	SIDM01519	Head and Neck Carcinoma	GDSC	LWGTPHYS	DEG_SCF_FBW7_1	0.0556
p.T1908A	ACH-000786	Lymphoma	CCLE	LWGTPHYS	DEG_SCF_FBW7_1	0.0556
p.T1908A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LWGTPHYS	DEG_SCF_FBW7_1	0.0556
p.T1908A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	LWGTPHYS	DEG_SCF_FBW7_1	0.0556
p.T1908A	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LWGTPHYS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SCF_FBW7_1	1918:1925	LWGTPHYS	FBXW7	0.9808	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons