DegronMD

Uniprot ID: Q8NDV7

Source protein: Trinucleotide repeat-containing gene 6A protein

Source gene: TNRC6A

Class: DEG_SPOP_SBC_1

Location: 1689:1693

E3 ligase: SPOP

DEGRON score: 0.876

ASA_SCORE: 65.56

COIL: 0.8128

CONS_SCORE: 0.3607

DSS_SCORE: 0.4745

HELIX: 0.1486

FCONS_SCORE: 0.8311

RIG_SCORE: 0.6704

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1683I	TCGA-BS-A0UV	UCEC	TCGA	AQSTS	DEG_SPOP_SBC_1	0.1667
p.V1683I	DO230342	COCA	ICGC	AQSTS	DEG_SPOP_SBC_1	0.1667
p.V1683I	DO42793	UCEC	ICGC	AQSTS	DEG_SPOP_SBC_1	0.1667
p.T1692A	DO222817	BTCA	ICGC	AQSTS	DEG_SPOP_SBC_1	0.7139
p.T1679A	CCK-81	large_intestine	COSMIC	AQSTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	1689:1693	AQSTS	SPOP	0.876	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_SPOP_SBC_1	753:757	AQSTS	SPOP	0.9901	More...
Q93074	Mediator of RNA polymerase II transcription subunit 12	DEG_SPOP_SBC_1	322:326	AQSTS	SPOP	0.8313	More...
Q96LZ2	Melanoma-associated antigen B10	DEG_SPOP_SBC_1	67:71	AQSTS	SPOP	0.9083	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons