DegronMD

Uniprot ID: Q96LZ2

Source protein: Melanoma-associated antigen B10

Source gene: MAGEB10

Class: DEG_SPOP_SBC_1

Location: 67:71

E3 ligase: SPOP

DEGRON score: 0.9083

ASA_SCORE: 68.18

COIL: 0.8302

CONS_SCORE: 0.2474

DSS_SCORE: 0.7132

HELIX: 0.0928

FCONS_SCORE: 0.9918

RIG_SCORE: 0.5995

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q68K	TCGA-NJ-A4YQ	LUAD	TCGA	AQSTS	DEG_SPOP_SBC_1	0.5833
p.Q68K	DO218944	LUAD	ICGC	AQSTS	DEG_SPOP_SBC_1	0.5833
p.E66K	TCGA-ZF-AA4V	BLCA	TCGA	AQSTS	DEG_SPOP_SBC_1	0.3056
p.E66K	DO219087	BLCA	ICGC	AQSTS	DEG_SPOP_SBC_1	0.3056
p.R65Q	DO230529	LUSC	ICGC	AQSTS	DEG_SPOP_SBC_1	0.2778
p.A74V	TCGA-AX-A2HD	UCEC	TCGA	AQSTS	DEG_SPOP_SBC_1	0.25
p.A74V	DO42608	UCEC	ICGC	AQSTS	DEG_SPOP_SBC_1	0.25
p.G63E	TCGA-FW-A3R5	SKCM	TCGA	AQSTS	DEG_SPOP_SBC_1	0.2222
p.G63E	DO37406	SKCM	ICGC	AQSTS	DEG_SPOP_SBC_1	0.2222
p.G63R	SIDM00850	Gastric Carcinoma	GDSC	AQSTS	DEG_SPOP_SBC_1	0.2222
p.G63R	ACH-000880	Gastric Cancer	CCLE	AQSTS	DEG_SPOP_SBC_1	0.2222
p.G63R	AGS	stomach	COSMIC	AQSTS	DEG_SPOP_SBC_1	0.2222
p.H62L	DO229177	LMS	ICGC	AQSTS	DEG_SPOP_SBC_1	0.1944
p.P61L	TCGA-B5-A3FC	UCEC	TCGA	AQSTS	DEG_SPOP_SBC_1	0.1667
p.P61L	DO41871	UCEC	ICGC	AQSTS	DEG_SPOP_SBC_1	0.1667
p.A77S	DO229019	LICA	ICGC	AQSTS	DEG_SPOP_SBC_1	0.1667
p.H79N	TCGA-49-AAR9	LUAD	TCGA	AQSTS	DEG_SPOP_SBC_1	0.1111
p.H79N	DO218921	LUAD	ICGC	AQSTS	DEG_SPOP_SBC_1	0.1111
p.N59T	TCGA-AP-A1DV	UCEC	TCGA	AQSTS	DEG_SPOP_SBC_1	0.1111
p.N59T	DO43186	UCEC	ICGC	AQSTS	DEG_SPOP_SBC_1	0.1111
p.N59T	ACH-001991	Primary	CCLE	AQSTS	DEG_SPOP_SBC_1	0.1111
p.A57E	DO227977	COCA	ICGC	AQSTS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 22 of 22 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q93074	Mediator of RNA polymerase II transcription subunit 12	DEG_SPOP_SBC_1	322:326	AQSTS	SPOP	0.8313	More...
Q96LZ2	Melanoma-associated antigen B10	DEG_SPOP_SBC_1	67:71	AQSTS	SPOP	0.9083	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_SPOP_SBC_1	753:757	AQSTS	SPOP	0.9901	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	1689:1693	AQSTS	SPOP	0.876	More...

Showing 1 to 4 of 4 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons