DegronMD

Uniprot ID: Q93074

Source protein: Mediator of RNA polymerase II transcription subunit 12

Source gene: MED12

Class: DEG_SPOP_SBC_1

Location: 322:326

E3 ligase: SPOP

DEGRON score: 0.8313

ASA_SCORE: 89.18

COIL: 0.91

CONS_SCORE: 0.342

DSS_SCORE: 0.5795

HELIX: 0.08

FCONS_SCORE: 0.9925

RIG_SCORE: 0.6092

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H318Y	TCGA-BF-AAP4	SKCM	TCGA	AQSTS	DEG_SPOP_SBC_1	0.2222
p.H318Y	DO219468	SKCM	ICGC	AQSTS	DEG_SPOP_SBC_1	0.2222
p.H318D	TCGA-CU-A72E	BLCA	TCGA	AQSTS	DEG_SPOP_SBC_1	0.2222
p.H318D	DO49734	BLCA	ICGC	AQSTS	DEG_SPOP_SBC_1	0.2222
p.A322V	TCGA-EO-A22U	UCEC	TCGA	AQSTS	DEG_SPOP_SBC_1	0.5825
p.A322V	DO43755	UCEC	ICGC	AQSTS	DEG_SPOP_SBC_1	0.5825
p.Q323E	TCGA-YF-AA3L	BLCA	TCGA	AQSTS	DEG_SPOP_SBC_1	0.5633
p.Q323E	DO51951	BLCA	ICGC	AQSTS	DEG_SPOP_SBC_1	0.5633
p.S316L	DO48190	ESCA	ICGC	AQSTS	DEG_SPOP_SBC_1	0.1667
p.T327K	DO50731	ORCA	ICGC	AQSTS	DEG_SPOP_SBC_1	0.3056
p.V312L	SIDM00789	Colorectal Carcinoma	GDSC	AQSTS	DEG_SPOP_SBC_1	0.0556
p.V312L	HCT-15	large_intestine	COSMIC	AQSTS	DEG_SPOP_SBC_1	0.0556
p.R330Q	C-33-A	cervix	COSMIC	AQSTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	1689:1693	AQSTS	SPOP	0.876	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_SPOP_SBC_1	753:757	AQSTS	SPOP	0.9901	More...
Q93074	Mediator of RNA polymerase II transcription subunit 12	DEG_SPOP_SBC_1	322:326	AQSTS	SPOP	0.8313	More...
Q96LZ2	Melanoma-associated antigen B10	DEG_SPOP_SBC_1	67:71	AQSTS	SPOP	0.9083	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons