DegronMD - Q93074(MED12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L807V	TCGA-55-7281	LUAD	TCGA	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation rewiring degron network	0.3056
p.L807V	DO25985	LUAD	ICGC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation rewiring degron network	0.3056
p.R815L	TCGA-55-7907	LUAD	TCGA	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation rewiring degron network	0.0833
p.R815L	DO25396	LUAD	ICGC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation rewiring degron network	0.0833
p.P2025T	TCGA-55-A492	LUAD	TCGA	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation altering degron motif	0.7031
p.R2015M	TCGA-62-A46O	LUAD	TCGA	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation rewiring degron network	0.1667
p.L799R	TCGA-85-8582	LUSC	TCGA	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation altering degron motif	0.7316
p.L799R	DO45491	LUSC	ICGC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation altering degron motif	0.7316
p.G1961S	TCGA-A5-A0G1	UCEC	TCGA	PPSY	ITCH	1965:1968	Mutation rewiring degron network	0.2222
p.V2038I	TCGA-AA-3864	COAD	TCGA	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation rewiring degron network	0.0556
p.G809E	TCGA-AP-A1DK	UCEC	TCGA	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation rewiring degron network	0.25
p.G809E	DO42033	UCEC	ICGC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation rewiring degron network	0.25
p.R815W	TCGA-AP-A1DV	UCEC	TCGA	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation rewiring degron network	0.0833
p.R815W	TCGA-B5-A3FC	UCEC	TCGA	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation rewiring degron network	0.0833
p.R815W	DO43186	UCEC	ICGC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation rewiring degron network	0.0833
p.R815W	DO41871	UCEC	ICGC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation rewiring degron network	0.0833
p.D811N	TCGA-B4-5836	KIRC	TCGA	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation rewiring degron network	0.1944
p.D811N	DO17878	KIRC	ICGC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation rewiring degron network	0.1944
p.Y1973C	TCGA-B5-A3FA	UCEC	TCGA	PPSY	ITCH	1965:1968	Mutation rewiring degron network	0.1944
p.P1966A	TCGA-B6-A0RS	BRCA	TCGA	PPSY	ITCH	1965:1968	Mutation altering degron motif	0.7503
p.H318Y	TCGA-BF-AAP4	SKCM	TCGA	AQSTS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.2222
p.H318Y	DO219468	SKCM	ICGC	AQSTS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.2222
p.A788E	TCGA-CM-6161	COAD	TCGA	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation rewiring degron network	0.1944
p.A788E	DO10116	COAD	ICGC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation rewiring degron network	0.1944
p.H318D	TCGA-CU-A72E	BLCA	TCGA	AQSTS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.2222
p.H318D	DO49734	BLCA	ICGC	AQSTS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.2222
p.P1978T	TCGA-D9-A148	SKCM	TCGA	PPSY	ITCH	1965:1968	Mutation rewiring degron network	0.0556
p.M2033I	TCGA-DK-A3X1	BLCA	TCGA	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation rewiring degron network	0.1944
p.P345S	TCGA-EE-A2GB	SKCM	TCGA	PPTSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1944
p.P345S	DO222683	MELA	ICGC	PPTSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1944
p.P345S	DO37417	SKCM	ICGC	PPTSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1944
p.A322V	TCGA-EO-A22U	UCEC	TCGA	AQSTS	DEG_SPOP_SBC_1	322:326	Mutation altering degron motif	0.5825
p.A322V	DO43755	UCEC	ICGC	AQSTS	DEG_SPOP_SBC_1	322:326	Mutation altering degron motif	0.5825
p.L350R	TCGA-EO-A3B0	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.0556
p.L350R	DO219773	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.0556
p.Q1939H	TCGA-MT-A67F	HNSC	TCGA	MTPSSS	DEG_SCF_FBW7_1	1930:1935	Mutation rewiring degron network	0.2222
p.P1959S	TCGA-RP-A693	SKCM	TCGA	PPSY	ITCH	1965:1968	Mutation rewiring degron network	0.1667
p.Q323E	TCGA-YF-AA3L	BLCA	TCGA	AQSTS	DEG_SPOP_SBC_1	322:326	Mutation altering degron motif	0.5633
p.Q323E	DO51951	BLCA	ICGC	AQSTS	DEG_SPOP_SBC_1	322:326	Mutation altering degron motif	0.5633
p.M2036I	DO447	BLCA	ICGC	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation rewiring degron network	0.1111
p.H2021Y	DO225028	BRCA	ICGC	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation altering degron motif	0.7229
p.P1969A	DO4012	BRCA	ICGC	PPSY	ITCH	1965:1968	Mutation rewiring degron network	0.3056
p.S2031N	DO230343	COCA	ICGC	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation rewiring degron network	0.25
p.S316L	DO48190	ESCA	ICGC	AQSTS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.1667
p.M1924I	DO233273	GACA	ICGC	MTPSSS	DEG_SCF_FBW7_1	1930:1935	Mutation rewiring degron network	0.1667
p.G1961C	DO233210	GACA	ICGC	PPSY	ITCH	1965:1968	Mutation rewiring degron network	0.2222
p.R784C	DO233633	GACA	ICGC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation rewiring degron network	0.0833
p.Q1942H	DO49070	HNSC	ICGC	MTPSSS	DEG_SCF_FBW7_1	1930:1935	Mutation rewiring degron network	0.1389
p.T344N	DO228650	LICA	ICGC	PPTSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.2222
p.G1961V	DO228952	LICA	ICGC	PPSY	ITCH	1965:1968	Mutation rewiring degron network	0.2222
p.P1962T	DO228899	LICA	ICGC	PPSY	ITCH	1965:1968	Mutation rewiring degron network	0.25
p.P2028T	DO23708	LUAD	ICGC	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation altering degron motif	0.7031
p.R2018M	DO26240	LUAD	ICGC	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation rewiring degron network	0.25
p.T327K	DO50731	ORCA	ICGC	AQSTS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.3056
p.T327K	DO50731	ORCA	ICGC	PPTSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.0833
p.P1962S	DO51268	SKCM	ICGC	PPSY	ITCH	1965:1968	Mutation rewiring degron network	0.25
p.Y1976C	DO52402	UCEC	ICGC	PPSY	ITCH	1965:1968	Mutation rewiring degron network	0.1111
p.G1964S	DO42472	UCEC	ICGC	PPSY	ITCH	1965:1968	Mutation rewiring degron network	0.3056
p.I2027M	SIDM00845	Burkitt's Lymphoma	GDSC	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation altering degron motif	0.6507
p.S2028G	SIDM00845	Burkitt's Lymphoma	GDSC	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation altering degron motif	0.6993
p.V312L	SIDM00789	Colorectal Carcinoma	GDSC	AQSTS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.0556
p.V312L	HCT-15	large intestine	COSMIC	AQSTS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.0556
p.A2035V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation rewiring degron network	0.1389
p.A2035V	ACH-002256	Leukemia	CCLE	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation rewiring degron network	0.1389
p.A2035V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation rewiring degron network	0.1389
p.D803Y	SIDM00465	Ovarian Carcinoma	GDSC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation altering degron motif	0.6214
p.D803Y	ACH-002183	Ovarian Cancer	CCLE	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation altering degron motif	0.6214
p.D803Y	OVMIU	ovary	COSMIC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation altering degron motif	0.6214
p.T1976I	SIDM00516	Melanoma	GDSC	PPSY	ITCH	1965:1968	Mutation rewiring degron network	0.1111
p.T1976I	ACH-002166	Skin Cancer	CCLE	PPSY	ITCH	1965:1968	Mutation rewiring degron network	0.1111
p.T1976I	MZ7-mel	skin	COSMIC	PPSY	ITCH	1965:1968	Mutation rewiring degron network	0.1111
p.R784H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation rewiring degron network	0.0833
p.R784H	ACH-001127	Leukemia	CCLE	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation rewiring degron network	0.0833
p.T2029S	SIDM00118	Colorectal Carcinoma	GDSC	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation rewiring degron network	0.3056
p.T2029S	ACH-001081	Colon/Colorectal Cancer	CCLE	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation rewiring degron network	0.3056
p.T2029S	HCC2998	large intestine	COSMIC	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation rewiring degron network	0.3056
p.L350F	ACH-000237	Ovarian Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.0556
p.T2021I	MCC13	skin	COSMIC	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation altering degron motif	0.7078
p.N787I	IA-LM	lung	COSMIC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation rewiring degron network	0.1667
p.A2034V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation rewiring degron network	0.1667
p.T1975I	MZ7-mel	skin	COSMIC	PPSY	ITCH	1965:1968	Mutation rewiring degron network	0.1389
p.D810Y	NCI-H1993	lung	COSMIC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	793:806	Mutation rewiring degron network	0.2222
p.T2028S	HCC2998	large intestine	COSMIC	LQQTPMIS	DEG_SCF_FBW7_1	2021:2028	Mutation altering degron motif	0.7116
p.R330Q	C-33-A	cervix	COSMIC	AQSTS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.2222
p.R330Q	C-33-A	cervix	COSMIC	PPTSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MED12

UniProt ID: Q93074

Entrez ID: 9968

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MED12 in