DegronMD

Uniprot ID: Q93074

Source protein: Mediator of RNA polymerase II transcription subunit 12

Source gene: MED12

Class: DEG_ODPH_VHL_1

Location: 793:806

E3 ligase: VHL

DEGRON score: 0.9901

ASA_SCORE: 65.3571

COIL: 0.7324

CONS_SCORE: 0.1563

DSS_SCORE: 0.4733

HELIX: 0.0766

FCONS_SCORE: 0.4267

RIG_SCORE: 0.7571

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L807V	TCGA-55-7281	LUAD	TCGA	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.3056
p.L807V	DO25985	LUAD	ICGC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.3056
p.R815L	TCGA-55-7907	LUAD	TCGA	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.0833
p.R815L	DO25396	LUAD	ICGC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.0833
p.L799R	TCGA-85-8582	LUSC	TCGA	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.7316
p.L799R	DO45491	LUSC	ICGC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.7316
p.G809E	TCGA-AP-A1DK	UCEC	TCGA	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.25
p.G809E	DO42033	UCEC	ICGC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.25
p.R815W	TCGA-AP-A1DV	UCEC	TCGA	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.0833
p.R815W	TCGA-B5-A3FC	UCEC	TCGA	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.0833
p.R815W	DO43186	UCEC	ICGC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.0833
p.R815W	DO41871	UCEC	ICGC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.0833
p.D811N	TCGA-B4-5836	KIRC	TCGA	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.1944
p.D811N	DO17878	KIRC	ICGC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.1944
p.A788E	TCGA-CM-6161	COAD	TCGA	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.1944
p.A788E	DO10116	COAD	ICGC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.1944
p.R784C	DO233633	GACA	ICGC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.0833
p.D803Y	SIDM00465	Ovarian Carcinoma	GDSC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.6214
p.D803Y	ACH-002183	Ovarian Cancer	CCLE	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.6214
p.D803Y	OVMIU	ovary	COSMIC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.6214
p.R784H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.0833
p.R784H	ACH-001127	Leukemia	CCLE	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.0833
p.N787I	IA-LM	lung	COSMIC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.1667
p.D810Y	NCI-H1993	lung	COSMIC	LAPIVPLNPGDLTF	DEG_ODPH_VHL_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q93074	Mediator of RNA polymerase II transcription subunit 12	DEG_ODPH_VHL_1	793:806	LAPIVPLNPGDLTF	VHL	0.9901	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPIVPLNPGDLTF

Degron related mutations and impact score

Drug responses associated with MED12 mutations

All proteins holding degron of LAPIVPLNPGDLTF