DegronMD

Uniprot ID: Q93074

Source protein: Mediator of RNA polymerase II transcription subunit 12

Source gene: MED12

Class: DEG_SCF_FBW7_1

Location: 1930:1935

E3 ligase: FBXW7

DEGRON score: 0.9938

ASA_SCORE: 81.6333

COIL: 0.9358

CONS_SCORE: 0.4099

DSS_SCORE: 0.5787

HELIX: 0.0383

FCONS_SCORE: 1.0982

RIG_SCORE: 0.6304

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1939H	TCGA-MT-A67F	HNSC	TCGA	MTPSSS	DEG_SCF_FBW7_1	0.2222
p.M1924I	DO233273	GACA	ICGC	MTPSSS	DEG_SCF_FBW7_1	0.1667
p.Q1942H	DO49070	HNSC	ICGC	MTPSSS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q93074	Mediator of RNA polymerase II transcription subunit 12	DEG_SCF_FBW7_1	1930:1935	MTPSSS	FBXW7	0.9938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons