DegronMD

Uniprot ID: Q93074

Source protein: Mediator of RNA polymerase II transcription subunit 12

Source gene: MED12

Class: DEG_SCF_FBW7_1

Location: 2021:2028

E3 ligase: FBXW7

DEGRON score: 0.6235

ASA_SCORE: 97.5375

COIL: 0.8671

CONS_SCORE: 0.3641

DSS_SCORE: 0.617

HELIX: 0.0955

FCONS_SCORE: 0.9767

RIG_SCORE: 0.7426

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2025T	TCGA-55-A492	LUAD	TCGA	LQQTPMIS	DEG_SCF_FBW7_1	0.7031
p.R2015M	TCGA-62-A46O	LUAD	TCGA	LQQTPMIS	DEG_SCF_FBW7_1	0.1667
p.V2038I	TCGA-AA-3864	COAD	TCGA	LQQTPMIS	DEG_SCF_FBW7_1	0.0556
p.M2033I	TCGA-DK-A3X1	BLCA	TCGA	LQQTPMIS	DEG_SCF_FBW7_1	0.1944
p.M2036I	DO447	BLCA	ICGC	LQQTPMIS	DEG_SCF_FBW7_1	0.1111
p.H2021Y	DO225028	BRCA	ICGC	LQQTPMIS	DEG_SCF_FBW7_1	0.7229
p.S2031N	DO230343	COCA	ICGC	LQQTPMIS	DEG_SCF_FBW7_1	0.25
p.P2028T	DO23708	LUAD	ICGC	LQQTPMIS	DEG_SCF_FBW7_1	0.7031
p.R2018M	DO26240	LUAD	ICGC	LQQTPMIS	DEG_SCF_FBW7_1	0.25
p.I2027M	SIDM00845	Burkitt's Lymphoma	GDSC	LQQTPMIS	DEG_SCF_FBW7_1	0.6507
p.S2028G	SIDM00845	Burkitt's Lymphoma	GDSC	LQQTPMIS	DEG_SCF_FBW7_1	0.6993
p.A2035V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LQQTPMIS	DEG_SCF_FBW7_1	0.1389
p.A2035V	ACH-002256	Leukemia	CCLE	LQQTPMIS	DEG_SCF_FBW7_1	0.1389
p.A2035V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LQQTPMIS	DEG_SCF_FBW7_1	0.1389
p.T2029S	SIDM00118	Colorectal Carcinoma	GDSC	LQQTPMIS	DEG_SCF_FBW7_1	0.3056
p.T2029S	ACH-001081	Colon/Colorectal Cancer	CCLE	LQQTPMIS	DEG_SCF_FBW7_1	0.3056
p.T2029S	HCC2998	large_intestine	COSMIC	LQQTPMIS	DEG_SCF_FBW7_1	0.3056
p.T2021I	MCC13	skin	COSMIC	LQQTPMIS	DEG_SCF_FBW7_1	0.7078
p.A2034V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LQQTPMIS	DEG_SCF_FBW7_1	0.1667
p.T2028S	HCC2998	large_intestine	COSMIC	LQQTPMIS	DEG_SCF_FBW7_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q93074	Mediator of RNA polymerase II transcription subunit 12	DEG_SCF_FBW7_1	2021:2028	LQQTPMIS	FBXW7	0.6235	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons