DegronMD

Uniprot ID: Q92540

Source protein: Nonsense-mediated mRNA decay factor SMG7

Source gene: SMG7

Class: DEG_SPOP_SBC_1

Location: 753:757

E3 ligase: SPOP

DEGRON score: 0.9901

ASA_SCORE: 71.06

COIL: 0.6744

CONS_SCORE: 0.3508

DSS_SCORE: 0.6526

HELIX: 0.308

FCONS_SCORE: 1.0521

RIG_SCORE: 0.6426

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q747R	TCGA-56-A49D	LUSC	TCGA	AQSTS	DEG_SPOP_SBC_1	0.1667
p.G765V	TCGA-G3-A5SL	LIHC	TCGA	AQSTS	DEG_SPOP_SBC_1	0.1111
p.Q761K	TCGA-ZJ-AB0I	CESC	TCGA	AQSTS	DEG_SPOP_SBC_1	0.2222
p.H767Y	DO218986	BLCA	ICGC	AQSTS	DEG_SPOP_SBC_1	0.0556
p.L747V	DO219732	CESC	ICGC	AQSTS	DEG_SPOP_SBC_1	0.1667
p.P766L	DO220877	MELA	ICGC	AQSTS	DEG_SPOP_SBC_1	0.0833
p.P765L	DO220911	MELA	ICGC	AQSTS	DEG_SPOP_SBC_1	0.1111
p.S753P	DO219881	SKCA	ICGC	AQSTS	DEG_SPOP_SBC_1	0.6752
p.A746T	DO41752	UCEC	ICGC	AQSTS	DEG_SPOP_SBC_1	0.1389
p.A746V	DO41434	UCEC	ICGC	AQSTS	DEG_SPOP_SBC_1	0.1389
p.G762C	SIDM02026	Colorectal Carcinoma	GDSC	AQSTS	DEG_SPOP_SBC_1	0.1944
p.G762S	SIDM00845	Burkitt's Lymphoma	GDSC	AQSTS	DEG_SPOP_SBC_1	0.1944
p.G762S	SIDM00035	Thyroid Gland Carcinoma	GDSC	AQSTS	DEG_SPOP_SBC_1	0.1944
p.G762S	SIDM01519	Head and Neck Carcinoma	GDSC	AQSTS	DEG_SPOP_SBC_1	0.1944
p.G762S	S-117	soft_tissue	COSMIC	AQSTS	DEG_SPOP_SBC_1	0.1944
p.T765A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AQSTS	DEG_SPOP_SBC_1	0.1111
p.F746V	23132-87	stomach	COSMIC	AQSTS	DEG_SPOP_SBC_1	0.1389
p.T748A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AQSTS	DEG_SPOP_SBC_1	0.1944
p.G766S	S-117	soft_tissue	COSMIC	AQSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	1689:1693	AQSTS	SPOP	0.876	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_SPOP_SBC_1	753:757	AQSTS	SPOP	0.9901	More...
Q93074	Mediator of RNA polymerase II transcription subunit 12	DEG_SPOP_SBC_1	322:326	AQSTS	SPOP	0.8313	More...
Q96LZ2	Melanoma-associated antigen B10	DEG_SPOP_SBC_1	67:71	AQSTS	SPOP	0.9083	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons