DegronMD - Q01484(ANK2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1882L	TCGA-04-1357	OV	TCGA	PVSST	DEG_SPOP_SBC_1	1892:1896	Mutation blocking phosphorylation signal	0.5
p.S1882L	DO27980	OV	ICGC	PVSST	DEG_SPOP_SBC_1	1892:1896	Mutation blocking phosphorylation signal	0.5
p.Q3076L	TCGA-17-Z021	LUAD	TCGA	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation rewiring degron network	0.2222
p.Q3076L	TCGA-17-Z021	LUAD	TCGA	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation rewiring degron network	0.1111
p.Q3076L	TCGA-17-Z031	LUAD	TCGA	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation rewiring degron network	0.2222
p.Q3076L	TCGA-17-Z031	LUAD	TCGA	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation rewiring degron network	0.1111
p.P3804T	TCGA-17-Z022	LUAD	TCGA	LQTPTSS	DEG_SCF_FBW7_1	3812:3818	Mutation rewiring degron network	0.1111
p.A3805P	TCGA-17-Z049	LUAD	TCGA	LQTPTSS	DEG_SCF_FBW7_1	3812:3818	Mutation rewiring degron network	0.1389
p.M2219I	TCGA-44-8119	LUAD	TCGA	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation altering degron motif	0.6507
p.M2219I	DO24399	LUAD	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation altering degron motif	0.6507
p.M2219I	DO222407	MELA	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation altering degron motif	0.6507
p.A2671V	TCGA-44-A47A	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.1389
p.A2671V	DO23976	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.1389
p.P3094Q	TCGA-49-4505	LUAD	TCGA	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation rewiring degron network	0.1389
p.P3094Q	TCGA-49-4505	LUAD	TCGA	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation rewiring degron network	0.25
p.P3094Q	DO25498	LUAD	ICGC	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation rewiring degron network	0.1389
p.P3094Q	DO25498	LUAD	ICGC	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation rewiring degron network	0.25
p.L2982S	TCGA-4B-A93V	LUAD	TCGA	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation rewiring degron network	0.1944
p.L2982S	DO218926	LUAD	ICGC	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation rewiring degron network	0.1944
p.I1763F	TCGA-55-7725	LUAD	TCGA	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation altering degron motif	0.6304
p.I1763F	DO24636	LUAD	ICGC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation altering degron motif	0.6304
p.P2223T	TCGA-55-7994	LUAD	TCGA	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation altering degron motif	0.7031
p.P2223T	DO45311	LUAD	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation altering degron motif	0.7031
p.P1749L	TCGA-55-A4DG	LUAD	TCGA	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation rewiring degron network	0.0833
p.P1749L	DO26337	LUAD	ICGC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation rewiring degron network	0.0833
p.S2663Y	TCGA-64-5778	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation altering degron motif	0.712
p.S2663Y	DO25837	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation altering degron motif	0.712
p.G1396D	TCGA-68-A59J	LUSC	TCGA	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.0556
p.G1396D	DO49085	LUSC	ICGC	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.0556
p.A2974S	TCGA-95-7567	LUAD	TCGA	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation altering degron motif	0.6477
p.A2974S	DO25564	LUAD	ICGC	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation altering degron motif	0.6477
p.V2972L	TCGA-97-8176	LUAD	TCGA	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation rewiring degron network	0.3056
p.V2972L	DO218933	LUAD	ICGC	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation rewiring degron network	0.3056
p.R1011C	TCGA-A5-A1OF	UCEC	TCGA	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.8301
p.R1011C	DO42568	UCEC	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.8301
p.T1002M	TCGA-A6-2681	COAD	TCGA	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.1111
p.T1002M	DO9788	COAD	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.1111
p.A2563V	TCGA-AA-3510	COAD	TCGA	DSENGE	DEG_Kelch_Keap1_1	2573:2578	Mutation rewiring degron network	0.0556
p.A2563V	TCGA-AA-3510	COAD	TCGA	VTPKTT	DEG_SCF_FBW7_1	2550:2555	Mutation rewiring degron network	0.1111
p.A2563V	DO7783	COAD	ICGC	DSENGE	DEG_Kelch_Keap1_1	2573:2578	Mutation rewiring degron network	0.0556
p.A2563V	DO7783	COAD	ICGC	VTPKTT	DEG_SCF_FBW7_1	2550:2555	Mutation rewiring degron network	0.1111
p.R1418C	TCGA-AA-3684	COAD	TCGA	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.1111
p.R1418C	TCGA-FI-A2D0	UCEC	TCGA	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.1111
p.R1418C	DO8802	COAD	ICGC	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.1111
p.R1418C	DO43891	UCEC	ICGC	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.1111
p.E1759K	TCGA-AA-A01P	COAD	TCGA	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation altering degron motif	0.591
p.E1759K	DO8642	COAD	ICGC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation altering degron motif	0.591
p.E1408K	TCGA-AC-A23H	BRCA	TCGA	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation altering degron motif	0.7022
p.E1408K	TCGA-EE-A2M5	SKCM	TCGA	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation altering degron motif	0.7022
p.E1408K	DO2401	BRCA	ICGC	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation altering degron motif	0.7022
p.E1408K	DO37425	SKCM	ICGC	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation altering degron motif	0.7022
p.E2234K	TCGA-AD-A5EJ	COAD	TCGA	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.1111
p.E2234K	DO50090	COAD	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.1111
p.R3820W	TCGA-AG-A002	READ	TCGA	LQTPTSS	DEG_SCF_FBW7_1	3812:3818	Mutation rewiring degron network	0.2778
p.R3820W	SIDM01273	Colorectal Carcinoma	GDSC	LQTPTSS	DEG_SCF_FBW7_1	3812:3818	Mutation rewiring degron network	0.2778
p.E3783D	TCGA-AP-A056	UCEC	TCGA	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation rewiring degron network	0.25
p.E3783D	DO43971	UCEC	ICGC	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation rewiring degron network	0.25
p.R1011H	TCGA-AP-A1DV	UCEC	TCGA	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.8244
p.R1011H	TCGA-D8-A1Y1	BRCA	TCGA	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.8244
p.R1011H	TCGA-FP-A4BF	STAD	TCGA	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.8244
p.R1011H	TCGA-G4-6588	COAD	TCGA	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.8244
p.R1011H	DO225337	BRCA	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.8244
p.R1011H	DO1398	BRCA	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.8244
p.R1011H	DO10140	COAD	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.8244
p.R1011H	DO223064	ESCA	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.8244
p.R1011H	DO218547	GACA	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.8244
p.R1011H	DO47775	STAD	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.8244
p.R1011H	DO43186	UCEC	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.8244
p.Q3770H	TCGA-B5-A11E	UCEC	TCGA	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation rewiring degron network	0.2222
p.Q3770H	DO41644	UCEC	ICGC	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation rewiring degron network	0.2222
p.A2974T	TCGA-BR-4184	STAD	TCGA	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation altering degron motif	0.6028
p.A2974T	DO38328	STAD	ICGC	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation altering degron motif	0.6028
p.H2566R	TCGA-BR-4361	STAD	TCGA	DSENGE	DEG_Kelch_Keap1_1	2573:2578	Mutation rewiring degron network	0.1389
p.H2566R	DO38887	STAD	ICGC	DSENGE	DEG_Kelch_Keap1_1	2573:2578	Mutation rewiring degron network	0.1389
p.T2555I	TCGA-BR-8081	STAD	TCGA	VTPKTT	DEG_SCF_FBW7_1	2550:2555	Mutation altering degron motif	0.7078
p.T2555I	DO38795	STAD	ICGC	VTPKTT	DEG_SCF_FBW7_1	2550:2555	Mutation altering degron motif	0.7078
p.S1755Y	TCGA-BS-A0UF	UCEC	TCGA	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation blocking phosphorylation signal	0.6944
p.S1755Y	DO41488	UCEC	ICGC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation blocking phosphorylation signal	0.6944
p.S2976F	TCGA-BS-A0UF	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation altering degron motif	0.7982
p.S2976F	DO41488	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation altering degron motif	0.7982
p.S2655L	TCGA-BS-A0UV	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.1944
p.S2655L	TCGA-YD-A9TA	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.1944
p.S2655L	DO230313	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.1944
p.S2655L	DO219503	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.1944
p.S2655L	DO42793	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.1944
p.S2655L	SIDM00193	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.1944
p.S2655L	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.1944
p.S2655L	SNU-81	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.1944
p.S2655L	SW900	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.1944
p.K1769N	TCGA-CG-4437	STAD	TCGA	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation substituting flanking lysine	0.3333
p.K1769N	DO38467	STAD	ICGC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation substituting flanking lysine	0.3333
p.S2657R	TCGA-CV-A45W	HNSC	TCGA	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation blocking phosphorylation signal	0.6944
p.S2657R	DO52060	HNSC	ICGC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation blocking phosphorylation signal	0.6944
p.S1891P	TCGA-CV-A461	HNSC	TCGA	PVSST	DEG_SPOP_SBC_1	1892:1896	Mutation blocking phosphorylation signal	0.75
p.S1891P	DO49058	HNSC	ICGC	PVSST	DEG_SPOP_SBC_1	1892:1896	Mutation blocking phosphorylation signal	0.75
p.R1013K	TCGA-D1-A103	UCEC	TCGA	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.6126
p.R1013K	DO42312	UCEC	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.6126
p.E3780K	TCGA-D9-A6EC	SKCM	TCGA	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation altering degron motif	0.7022
p.E3780K	DO50291	SKCM	ICGC	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation altering degron motif	0.7022
p.E2586K	TCGA-DA-A1IC	SKCM	TCGA	DSENGE	DEG_Kelch_Keap1_1	2573:2578	Mutation rewiring degron network	0.1111
p.E2586K	DO37430	SKCM	ICGC	DSENGE	DEG_Kelch_Keap1_1	2573:2578	Mutation rewiring degron network	0.1111
p.P3088A	TCGA-DD-A4NV	LIHC	TCGA	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation altering degron motif	0.7503
p.P3088A	DO44876	LIHC	ICGC	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation altering degron motif	0.7503
p.S2975I	TCGA-DD-AADW	LIHC	TCGA	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation altering degron motif	0.7341
p.S2975I	DO52249	LIHC	ICGC	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation altering degron motif	0.7341
p.G2235C	TCGA-DU-6392	LGG	TCGA	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.0833
p.G2235C	DO22237	LGG	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.0833
p.N2987K	TCGA-E6-A1LX	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation rewiring degron network	0.0556
p.N2987K	DO41020	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation rewiring degron network	0.0556
p.E2220K	TCGA-E6-A2P9	UCEC	TCGA	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation altering degron motif	0.591
p.E2220K	DO43714	UCEC	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation altering degron motif	0.591
p.P2552H	TCGA-EE-A2MK	SKCM	TCGA	VTPKTT	DEG_SCF_FBW7_1	2550:2555	Mutation altering degron motif	0.7694
p.P2552H	DO38177	SKCM	ICGC	VTPKTT	DEG_SCF_FBW7_1	2550:2555	Mutation altering degron motif	0.7694
p.P1892H	TCGA-EE-A3AD	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	1892:1896	Mutation altering degron motif	0.7694
p.P1892H	DO37707	SKCM	ICGC	PVSST	DEG_SPOP_SBC_1	1892:1896	Mutation altering degron motif	0.7694
p.S1891F	TCGA-EE-A3AG	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	1892:1896	Mutation blocking phosphorylation signal	0.75
p.S1891F	DO37471	SKCM	ICGC	PVSST	DEG_SPOP_SBC_1	1892:1896	Mutation blocking phosphorylation signal	0.75
p.P2214S	TCGA-EE-A3AG	SKCM	TCGA	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.1944
p.P2214S	DO37471	SKCM	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.1944
p.P1749T	TCGA-EI-6917	READ	TCGA	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation rewiring degron network	0.0833
p.P1749T	DO36881	READ	ICGC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation rewiring degron network	0.0833
p.K1407E	TCGA-EM-A3OA	THCA	TCGA	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation altering degron motif	0.7022
p.K1407E	DO48161	THCA	ICGC	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation altering degron motif	0.7022
p.A3787V	TCGA-EO-A22U	UCEC	TCGA	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation rewiring degron network	0.1389
p.A3787V	DO43755	UCEC	ICGC	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation rewiring degron network	0.1389
p.P3824L	TCGA-FI-A2F4	UCEC	TCGA	LQTPTSS	DEG_SCF_FBW7_1	3812:3818	Mutation rewiring degron network	0.1667
p.P3824L	DO43434	UCEC	ICGC	LQTPTSS	DEG_SCF_FBW7_1	3812:3818	Mutation rewiring degron network	0.1667
p.P2214T	TCGA-FJ-A3ZE	BLCA	TCGA	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.1944
p.P2214T	DO484	BLCA	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.1944
p.S1905L	TCGA-FR-A728	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	1892:1896	Mutation blocking phosphorylation signal	0.5278
p.S1905L	DO51142	PRAD	ICGC	PVSST	DEG_SPOP_SBC_1	1892:1896	Mutation blocking phosphorylation signal	0.5278
p.S1905L	DO48550	SKCM	ICGC	PVSST	DEG_SPOP_SBC_1	1892:1896	Mutation blocking phosphorylation signal	0.5278
p.P1906L	TCGA-FW-A3R5	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	1892:1896	Mutation rewiring degron network	0.0556
p.P1906L	DO37406	SKCM	ICGC	PVSST	DEG_SPOP_SBC_1	1892:1896	Mutation rewiring degron network	0.0556
p.S2662F	TCGA-FW-A3R5	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation altering degron motif	0.7982
p.S2662F	DO37406	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation altering degron motif	0.7982
p.E1022K	TCGA-GC-A3YS	BLCA	TCGA	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.2222
p.E1022K	DO850	BLCA	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.2222
p.Q3827R	TCGA-HU-A4G8	STAD	TCGA	LQTPTSS	DEG_SCF_FBW7_1	3812:3818	Mutation rewiring degron network	0.0833
p.Q3827R	DO47819	STAD	ICGC	LQTPTSS	DEG_SCF_FBW7_1	3812:3818	Mutation rewiring degron network	0.0833
p.C2568G	TCGA-HV-A5A5	PAAD	TCGA	DSENGE	DEG_Kelch_Keap1_1	2573:2578	Mutation rewiring degron network	0.1944
p.C2568G	DO223708	PAAD	ICGC	DSENGE	DEG_Kelch_Keap1_1	2573:2578	Mutation rewiring degron network	0.1944
p.D2573N	TCGA-J2-A4AD	LUAD	TCGA	DSENGE	DEG_Kelch_Keap1_1	2573:2578	Mutation altering degron motif	0.5821
p.D2573N	DO23915	LUAD	ICGC	DSENGE	DEG_Kelch_Keap1_1	2573:2578	Mutation altering degron motif	0.5821
p.P3100R	TCGA-OR-A5KB	ACC	TCGA	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation rewiring degron network	0.0833
p.D3081E	TCGA-R6-A6KZ	ESCA	TCGA	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation altering degron motif	0.5647
p.T2963A	TCGA-UB-A7MB	LIHC	TCGA	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation rewiring degron network	0.0556
p.T2963A	DO52318	LIHC	ICGC	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation rewiring degron network	0.0556
p.R1418H	TCGA-VQ-A8PT	STAD	TCGA	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.1111
p.R1418H	DO51776	STAD	ICGC	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.1111
p.P2214L	TCGA-ZF-AA51	BLCA	TCGA	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.1944
p.P2214L	DO219093	BLCA	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.1944
p.P2214L	SIDM00292	Small Cell Lung Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.1944
p.P2214L	LU-165	lung	COSMIC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.1944
p.E1760K	DO48360	BLCA	ICGC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation altering degron motif	0.591
p.M2219T	DO217800	BRCA	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation altering degron motif	0.7423
p.H1901R	DO229323	BTCA	ICGC	PVSST	DEG_SPOP_SBC_1	1892:1896	Mutation rewiring degron network	0.1944
p.K1769E	DO227987	COCA	ICGC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation substituting flanking lysine	0.3333
p.H1890Y	DO222762	COCA	ICGC	PVSST	DEG_SPOP_SBC_1	1892:1896	Mutation rewiring degron network	0.2778
p.D1419N	DO234230	ESAD	ICGC	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.0833
p.P2560T	DO228740	GACA	ICGC	VTPKTT	DEG_SCF_FBW7_1	2550:2555	Mutation rewiring degron network	0.1944
p.S2542I	DO229018	LICA	ICGC	VTPKTT	DEG_SCF_FBW7_1	2550:2555	Mutation rewiring degron network	0.1111
p.V2564L	DO229019	LICA	ICGC	DSENGE	DEG_Kelch_Keap1_1	2573:2578	Mutation rewiring degron network	0.0833
p.V2564L	DO229019	LICA	ICGC	VTPKTT	DEG_SCF_FBW7_1	2550:2555	Mutation rewiring degron network	0.0833
p.D1419Y	DO229029	LICA	ICGC	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.0833
p.V1415F	DO229041	LICA	ICGC	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.1944
p.G1025S	DO23400	LINC	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.1389
p.A1772P	DO45299	LIRI	ICGC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation rewiring degron network	0.1389
p.P3080H	DO230530	LUSC	ICGC	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation altering degron motif	0.7694
p.G3077V	DO231169	LUSC	ICGC	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation rewiring degron network	0.25
p.G3077V	DO231169	LUSC	ICGC	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation rewiring degron network	0.1389
p.H1012N	DO231204	LUSC	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.6312
p.P3100L	DO220852	MELA	ICGC	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation rewiring degron network	0.0833
p.T3779I	DO220902	MELA	ICGC	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation altering degron motif	0.5966
p.P1892S	DO222847	MELA	ICGC	PVSST	DEG_SPOP_SBC_1	1892:1896	Mutation altering degron motif	0.6752
p.K2674R	DO46366	OV	ICGC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation substituting flanking lysine	0.1667
p.S1765F	DO229494	SKCA	ICGC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation altering degron motif	0.7982
p.S1765F	SIDM00401	Melanoma	GDSC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation altering degron motif	0.7982
p.S1765F	RVH-421	skin	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation altering degron motif	0.7982
p.L1748F	DO229446	SKCA	ICGC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation rewiring degron network	0.0556
p.N1409K	DO229208	THCA	ICGC	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation altering degron motif	0.6918
p.S2226T	SIDM01274	Esophageal Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation altering degron motif	0.6005
p.L1411F	SIDM01141	Ovarian Carcinoma	GDSC	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.3056
p.L1411F	OV-90	ovary	COSMIC	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.3056
p.I2964M	SIDM01036	Plasma Cell Myeloma	GDSC	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation rewiring degron network	0.0833
p.E2665D	SIDM00545	Melanoma	GDSC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.3056
p.E2665D	Mewo	skin	COSMIC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.3056
p.K3786E	SIDM00617	Hepatocellular Carcinoma	GDSC	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation substituting flanking lysine	0.2778
p.K3786E	JHH-2	liver	COSMIC	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation substituting flanking lysine	0.2778
p.H1012R	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.7133
p.H1012R	ACH-002272	Lymphoma	CCLE	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.7133
p.H1012R	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.7133
p.P1883H	SIDM00473	Oral Cavity Carcinoma	GDSC	PVSST	DEG_SPOP_SBC_1	1892:1896	Mutation rewiring degron network	0.0833
p.P1883H	PE/CA-PJ15	upper aerodigestive tract	COSMIC	PVSST	DEG_SPOP_SBC_1	1892:1896	Mutation rewiring degron network	0.0833
p.T3083N	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation altering degron motif	0.8166
p.T3083N	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation altering degron motif	0.8166
p.G2212S	SIDM01117	Small Cell Lung Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.1389
p.G2212S	SIDM00032	Bladder Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.1389
p.G2212S	SIDM00431	T-Lymphoblastic Leukemia	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.1389
p.G2212S	SIDM00721	Small Cell Lung Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.1389
p.G2212S	SIDM01664	Prostate Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.1389
p.G2212S	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.1389
p.G2212S	SIDM01387	Small Cell Lung Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.1389
p.P3088T	SIDM00120	Prostate Carcinoma	GDSC	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation altering degron motif	0.7031
p.P3088T	DU-145	prostate	COSMIC	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation altering degron motif	0.7031
p.P1762S	SIDM01175	Other Sarcomas	GDSC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation altering degron motif	0.6752
p.P1762S	SW684	soft tissue	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation altering degron motif	0.6752
p.P1762L	SIDM01175	Other Sarcomas	GDSC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation altering degron motif	0.7582
p.P1762L	SW684	soft tissue	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation altering degron motif	0.7582
p.D2970N	SIDM00041	Gastric Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation rewiring degron network	0.25
p.D2970N	STS-0421	soft tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation rewiring degron network	0.25
p.S3096G	SIDM00633	Breast Carcinoma	GDSC	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation rewiring degron network	0.0833
p.S3096G	SIDM00633	Breast Carcinoma	GDSC	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation rewiring degron network	0.1944
p.S3096G	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation rewiring degron network	0.0833
p.S3096G	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation rewiring degron network	0.1944
p.G3821E	SIDM00633	Breast Carcinoma	GDSC	LQTPTSS	DEG_SCF_FBW7_1	3812:3818	Mutation rewiring degron network	0.25
p.G3821E	MDA-MB-175-VII	breast	COSMIC	LQTPTSS	DEG_SCF_FBW7_1	3812:3818	Mutation rewiring degron network	0.25
p.P2650T	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.0556
p.P2650T	NCI-H358	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.0556
p.R3820Q	SIDM01112	Osteosarcoma	GDSC	LQTPTSS	DEG_SCF_FBW7_1	3812:3818	Mutation rewiring degron network	0.2778
p.Q3785R	SIDM00060	Ovarian Carcinoma	GDSC	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation rewiring degron network	0.1944
p.D1419E	SIDM00282	Colorectal Carcinoma	GDSC	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.0833
p.D1419E	CW-2	large intestine	COSMIC	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation rewiring degron network	0.0833
p.G2216C	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.25
p.G2216C	H513	pleura	COSMIC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.25
p.R1007Q	SIDM00819	Kidney Carcinoma	GDSC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.25
p.R1007Q	ACH-002189	Kidney Cancer	CCLE	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.25
p.R1007Q	RCC-FG2	kidney	COSMIC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.25
p.P2668H	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.2222
p.P2668H	CAL-12T	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.2222
p.N2576K	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	DSENGE	DEG_Kelch_Keap1_1	2573:2578	Mutation altering degron motif	0.6918
p.N2576K	LCLC-103H	lung	COSMIC	DSENGE	DEG_Kelch_Keap1_1	2573:2578	Mutation altering degron motif	0.6918
p.T3095S	SIDM01146	Gastric Carcinoma	GDSC	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation rewiring degron network	0.1111
p.T3095S	SIDM01146	Gastric Carcinoma	GDSC	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation rewiring degron network	0.2222
p.T3095S	NCI-SNU-1	stomach	COSMIC	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation rewiring degron network	0.1111
p.T3095S	NCI-SNU-1	stomach	COSMIC	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation rewiring degron network	0.2222
p.V3774M	SIDM00502	B-Lymphoblastic Leukemia	GDSC	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation altering degron motif	0.6097
p.V3774M	SIDM00613	Glioblastoma	GDSC	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation altering degron motif	0.6097
p.V3774M	SIDM00160	Biliary Tract Carcinoma	GDSC	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation altering degron motif	0.6097
p.V3774M	SIDM01321	Pancreatic Carcinoma	GDSC	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation altering degron motif	0.6097
p.V3774M	KALS-1	central nervous system	COSMIC	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation altering degron motif	0.6097
p.V3774M	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation altering degron motif	0.6097
p.E2656D	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.2222
p.E2656D	NCI-H1623	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.2222
p.G2209W	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.0556
p.G2209W	NCI-H2342	lung	COSMIC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.0556
p.N3099S	SIDM00217	Colorectal Carcinoma	GDSC	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation rewiring degron network	0.1111
p.N3099S	SNU-1040	large intestine	COSMIC	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation rewiring degron network	0.1111
p.V2651L	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	2660:2664	Mutation rewiring degron network	0.0833
p.S1895Y	SIDM01316	Ewing's Sarcoma	GDSC	PVSST	DEG_SPOP_SBC_1	1892:1896	Mutation altering degron motif	0.712
p.R1003Q	SIDM01588	Endometrial Carcinoma	GDSC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.1389
p.R1003Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.1389
p.E3766Q	ACH-000490	Cervical Cancer	CCLE	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation rewiring degron network	0.1111
p.T3079A	ACH-000589	Lung Cancer	CCLE	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation blocking phosphorylation signal	0.75
p.T3079A	ACH-000589	Lung Cancer	CCLE	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation blocking phosphorylation signal	0.6389
p.T3079A	NCI-H1437	lung	COSMIC	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation blocking phosphorylation signal	0.75
p.T3079A	NCI-H1437	lung	COSMIC	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation blocking phosphorylation signal	0.6389
p.N2543K	ACH-000627	Lung Cancer	CCLE	VTPKTT	DEG_SCF_FBW7_1	2550:2555	Mutation rewiring degron network	0.1389
p.N2543K	LCLC-103H	lung	COSMIC	VTPKTT	DEG_SCF_FBW7_1	2550:2555	Mutation rewiring degron network	0.1389
p.D1763E	ACH-000680	Colon/Colorectal Cancer	CCLE	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation altering degron motif	0.6758
p.D1763E	SW948	large intestine	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation altering degron motif	0.6758
p.G3788E	ACH-000759	Breast Cancer	CCLE	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation rewiring degron network	0.1111
p.G3788E	MDA-MB-175-VII	breast	COSMIC	VTTPGTE	DEG_SCF_FBW7_2	3774:3780	Mutation rewiring degron network	0.1111
p.K1767R	ACH-000847	Gastric Cancer	CCLE	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation rewiring degron network	0.2778
p.K1767R	HGC-27	stomach	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation rewiring degron network	0.2778
p.Q2584L	ACH-000884	Skin Cancer	CCLE	DSENGE	DEG_Kelch_Keap1_1	2573:2578	Mutation rewiring degron network	0.1667
p.Q2584L	ACH-002159	Skin Cancer	CCLE	DSENGE	DEG_Kelch_Keap1_1	2573:2578	Mutation rewiring degron network	0.1667
p.Q2584L	M14	skin	COSMIC	DSENGE	DEG_Kelch_Keap1_1	2573:2578	Mutation rewiring degron network	0.1667
p.E3817V	ACH-000900	Lung Cancer	CCLE	LQTPTSS	DEG_SCF_FBW7_1	3812:3818	Mutation altering degron motif	0.7693
p.E3817V	NCI-H23	lung	COSMIC	LQTPTSS	DEG_SCF_FBW7_1	3812:3818	Mutation altering degron motif	0.7693
p.M3078T	ACH-000909	Endometrial/Uterine Cancer	CCLE	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation rewiring degron network	0.2778
p.M3078T	ACH-000909	Endometrial/Uterine Cancer	CCLE	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation rewiring degron network	0.1667
p.E2227K	ACH-000910	Breast Cancer	CCLE	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.3056
p.E2227K	MDA-MB-453	breast	COSMIC	MEGTPQIS	DEG_SCF_FBW7_1	2219:2226	Mutation rewiring degron network	0.3056
p.E3094K	ACH-000910	Breast Cancer	CCLE	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation rewiring degron network	0.1389
p.E3094K	ACH-000910	Breast Cancer	CCLE	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation rewiring degron network	0.25
p.E3094K	MDA-MB-453	breast	COSMIC	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation rewiring degron network	0.1389
p.E3094K	MDA-MB-453	breast	COSMIC	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation rewiring degron network	0.25
p.S3081T	ACH-000916	Lung Cancer	CCLE	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation altering degron motif	0.7116
p.S3081T	NCI-H1573	lung	COSMIC	PDTTPART	DEG_SCF_FBW7_1	3080:3087	Mutation altering degron motif	0.7116
p.R2576M	ACH-000988	Endometrial/Uterine Cancer	CCLE	DSENGE	DEG_Kelch_Keap1_1	2573:2578	Mutation altering degron motif	0.8632
p.R2576M	MFE-319	endometrium	COSMIC	DSENGE	DEG_Kelch_Keap1_1	2573:2578	Mutation altering degron motif	0.8632
p.T2985A	ACH-000990	Endometrial/Uterine Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation rewiring degron network	0.1111
p.H1770Y	ACH-000999	Colon/Colorectal Cancer	CCLE	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation rewiring degron network	0.1944
p.H1770Y	SNU-1040	large intestine	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation rewiring degron network	0.1944
p.E2972K	ACH-001362	Lung Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation rewiring degron network	0.3056
p.E2972K	NCI-H1770	lung	COSMIC	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation rewiring degron network	0.3056
p.E2963D	ACH-001738	Leukemia	CCLE	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation rewiring degron network	0.0556
p.E2963D	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	2973:2977	Mutation rewiring degron network	0.0556
p.K1759I	ACH-002163	Breast Cancer	CCLE	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation altering degron motif	0.7531
p.K1759I	MRK-nu-1	breast	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation altering degron motif	0.7531
p.N1769K	H3255	lung	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation substituting flanking lysine	0.3333
p.Q1012R	SNU-C5	large intestine	COSMIC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.7329
p.A3819D	H513	pleura	COSMIC	LQTPTSS	DEG_SCF_FBW7_1	3812:3818	Mutation rewiring degron network	0.3056
p.Q3100K	BHY	upper aerodigestive tract	COSMIC	PARTPTEE	DEG_SCF_FBW7_2	3084:3091	Mutation rewiring degron network	0.0833
p.E1756V	NCI-H23	lung	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation rewiring degron network	0.2778
p.N1760K	H3255	lung	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation altering degron motif	0.6918
p.L1402F	OV-90	ovary	COSMIC	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation blocking phosphorylation signal	0.6667
p.A1758D	H513	pleura	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation altering degron motif	0.7793
p.D1025V	DBTRG-05MG	central nervous system	COSMIC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.1389
p.A1767D	H513	pleura	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation rewiring degron network	0.2778
p.H1003R	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	KRHRLATMP	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.1389
p.D1410E	CW-2	large intestine	COSMIC	FKENR	DEG_APCC_KENBOX_2	1406:1410	Mutation altering degron motif	0.6758
p.E1765V	NCI-H23	lung	COSMIC	IEETPIGS	DEG_SCF_FBW7_1	1758:1765	Mutation altering degron motif	0.7693
p.N3821K	H3255	lung	COSMIC	LQTPTSS	DEG_SCF_FBW7_1	3812:3818	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANK2

UniProt ID: Q01484

Entrez ID: 287

Protein name: Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANK2 in