DegronMD

Uniprot ID: Q01484

Source protein: Ankyrin-2

Source gene: ANK2

Class: DEG_SCF_FBW7_1

Location: 2219:2226

E3 ligase: FBXW7

DEGRON score: 0.6822

ASA_SCORE: 87.2125

COIL: 0.7776

CONS_SCORE: 0.4503

DSS_SCORE: 0.6406

HELIX: 0.0301

FCONS_SCORE: 1.0524

RIG_SCORE: 0.634

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M2219I	TCGA-44-8119	LUAD	TCGA	MEGTPQIS	DEG_SCF_FBW7_1	0.6507
p.M2219I	DO24399	LUAD	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	0.6507
p.M2219I	DO222407	MELA	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	0.6507
p.P2223T	TCGA-55-7994	LUAD	TCGA	MEGTPQIS	DEG_SCF_FBW7_1	0.7031
p.P2223T	DO45311	LUAD	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	0.7031
p.E2234K	TCGA-AD-A5EJ	COAD	TCGA	MEGTPQIS	DEG_SCF_FBW7_1	0.1111
p.E2234K	DO50090	COAD	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	0.1111
p.G2235C	TCGA-DU-6392	LGG	TCGA	MEGTPQIS	DEG_SCF_FBW7_1	0.0833
p.G2235C	DO22237	LGG	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	0.0833
p.E2220K	TCGA-E6-A2P9	UCEC	TCGA	MEGTPQIS	DEG_SCF_FBW7_1	0.591
p.E2220K	DO43714	UCEC	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	0.591
p.P2214S	TCGA-EE-A3AG	SKCM	TCGA	MEGTPQIS	DEG_SCF_FBW7_1	0.1944
p.P2214S	DO37471	SKCM	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	0.1944
p.P2214T	TCGA-FJ-A3ZE	BLCA	TCGA	MEGTPQIS	DEG_SCF_FBW7_1	0.1944
p.P2214T	DO484	BLCA	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	0.1944
p.P2214L	TCGA-ZF-AA51	BLCA	TCGA	MEGTPQIS	DEG_SCF_FBW7_1	0.1944
p.P2214L	DO219093	BLCA	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	0.1944
p.P2214L	SIDM00292	Small Cell Lung Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	0.1944
p.P2214L	LU-165	lung	COSMIC	MEGTPQIS	DEG_SCF_FBW7_1	0.1944
p.M2219T	DO217800	BRCA	ICGC	MEGTPQIS	DEG_SCF_FBW7_1	0.7423
p.S2226T	SIDM01274	Esophageal Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	0.6005
p.G2212S	SIDM01117	Small Cell Lung Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	0.1389
p.G2212S	SIDM00032	Bladder Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	0.1389
p.G2212S	SIDM00431	T-Lymphoblastic Leukemia	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	0.1389
p.G2212S	SIDM00721	Small Cell Lung Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	0.1389
p.G2212S	SIDM01664	Prostate Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	0.1389
p.G2212S	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	0.1389
p.G2212S	SIDM01387	Small Cell Lung Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	0.1389
p.G2216C	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	0.25
p.G2216C	H513	pleura	COSMIC	MEGTPQIS	DEG_SCF_FBW7_1	0.25
p.G2209W	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	MEGTPQIS	DEG_SCF_FBW7_1	0.0556
p.G2209W	NCI-H2342	lung	COSMIC	MEGTPQIS	DEG_SCF_FBW7_1	0.0556
p.E2227K	ACH-000910	Breast Cancer	CCLE	MEGTPQIS	DEG_SCF_FBW7_1	0.3056
p.E2227K	MDA-MB-453	breast	COSMIC	MEGTPQIS	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MEGTPQIS

Degron related mutations and impact score

Drug responses associated with ANK2 mutations

All proteins holding degron of MEGTPQIS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01484	Ankyrin-2	DEG_SCF_FBW7_1	2219:2226	MEGTPQIS	FBXW7	0.6822	More...