DegronMD

Uniprot ID: Q01484

Source protein: Ankyrin-2

Source gene: ANK2

Class: DEG_APCC_DBOX_1

Location: 1010:1018

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6372

ASA_SCORE: 89.6778

COIL: 0.6993

CONS_SCORE: 0.5298

DSS_SCORE: 0.3395

HELIX: 0.1623

FCONS_SCORE: 0.8431

RIG_SCORE: 0.8107

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1011C	TCGA-A5-A1OF	UCEC	TCGA	KRHRLATMP	DEG_APCC_DBOX_1	0.8301
p.R1011C	DO42568	UCEC	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	0.8301
p.T1002M	TCGA-A6-2681	COAD	TCGA	KRHRLATMP	DEG_APCC_DBOX_1	0.1111
p.T1002M	DO9788	COAD	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	0.1111
p.R1011H	TCGA-AP-A1DV	UCEC	TCGA	KRHRLATMP	DEG_APCC_DBOX_1	0.8244
p.R1011H	TCGA-D8-A1Y1	BRCA	TCGA	KRHRLATMP	DEG_APCC_DBOX_1	0.8244
p.R1011H	TCGA-FP-A4BF	STAD	TCGA	KRHRLATMP	DEG_APCC_DBOX_1	0.8244
p.R1011H	TCGA-G4-6588	COAD	TCGA	KRHRLATMP	DEG_APCC_DBOX_1	0.8244
p.R1011H	DO225337	BRCA	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	0.8244
p.R1011H	DO1398	BRCA	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	0.8244
p.R1011H	DO10140	COAD	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	0.8244
p.R1011H	DO223064	ESCA	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	0.8244
p.R1011H	DO218547	GACA	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	0.8244
p.R1011H	DO47775	STAD	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	0.8244
p.R1011H	DO43186	UCEC	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	0.8244
p.R1013K	TCGA-D1-A103	UCEC	TCGA	KRHRLATMP	DEG_APCC_DBOX_1	0.6126
p.R1013K	DO42312	UCEC	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	0.6126
p.E1022K	TCGA-GC-A3YS	BLCA	TCGA	KRHRLATMP	DEG_APCC_DBOX_1	0.2222
p.E1022K	DO850	BLCA	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	0.2222
p.G1025S	DO23400	LINC	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	0.1389
p.H1012N	DO231204	LUSC	ICGC	KRHRLATMP	DEG_APCC_DBOX_1	0.6312
p.H1012R	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	KRHRLATMP	DEG_APCC_DBOX_1	0.7133
p.H1012R	ACH-002272	Lymphoma	CCLE	KRHRLATMP	DEG_APCC_DBOX_1	0.7133
p.H1012R	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	KRHRLATMP	DEG_APCC_DBOX_1	0.7133
p.R1007Q	SIDM00819	Kidney Carcinoma	GDSC	KRHRLATMP	DEG_APCC_DBOX_1	0.25
p.R1007Q	ACH-002189	Kidney Cancer	CCLE	KRHRLATMP	DEG_APCC_DBOX_1	0.25
p.R1007Q	RCC-FG2	kidney	COSMIC	KRHRLATMP	DEG_APCC_DBOX_1	0.25
p.R1003Q	SIDM01588	Endometrial Carcinoma	GDSC	KRHRLATMP	DEG_APCC_DBOX_1	0.1389
p.R1003Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	KRHRLATMP	DEG_APCC_DBOX_1	0.1389
p.Q1012R	SNU-C5	large_intestine	COSMIC	KRHRLATMP	DEG_APCC_DBOX_1	0.7329
p.D1025V	DBTRG-05MG	central_nervous_system	COSMIC	KRHRLATMP	DEG_APCC_DBOX_1	0.1389
p.H1003R	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	KRHRLATMP	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRHRLATMP

Degron related mutations and impact score

Drug responses associated with ANK2 mutations

All proteins holding degron of KRHRLATMP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01484	Ankyrin-2	DEG_APCC_DBOX_1	1010:1018	KRHRLATMP	APC,CDC20,FZR1	0.6372	More...