DegronMD

Uniprot ID: Q01484

Source protein: Ankyrin-2

Source gene: ANK2

Class: DEG_SCF_FBW7_1

Location: 3812:3818

E3 ligase: FBXW7

DEGRON score: 0.9751

ASA_SCORE: 87.3

COIL: 0.8127

CONS_SCORE: 0.3899

DSS_SCORE: 0.7406

HELIX: 0.0647

FCONS_SCORE: 1.0485

RIG_SCORE: 0.6401

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3804T	TCGA-17-Z022	LUAD	TCGA	LQTPTSS	DEG_SCF_FBW7_1	0.1111
p.A3805P	TCGA-17-Z049	LUAD	TCGA	LQTPTSS	DEG_SCF_FBW7_1	0.1389
p.R3820W	TCGA-AG-A002	READ	TCGA	LQTPTSS	DEG_SCF_FBW7_1	0.2778
p.R3820W	SIDM01273	Colorectal Carcinoma	GDSC	LQTPTSS	DEG_SCF_FBW7_1	0.2778
p.P3824L	TCGA-FI-A2F4	UCEC	TCGA	LQTPTSS	DEG_SCF_FBW7_1	0.1667
p.P3824L	DO43434	UCEC	ICGC	LQTPTSS	DEG_SCF_FBW7_1	0.1667
p.Q3827R	TCGA-HU-A4G8	STAD	TCGA	LQTPTSS	DEG_SCF_FBW7_1	0.0833
p.Q3827R	DO47819	STAD	ICGC	LQTPTSS	DEG_SCF_FBW7_1	0.0833
p.G3821E	SIDM00633	Breast Carcinoma	GDSC	LQTPTSS	DEG_SCF_FBW7_1	0.25
p.G3821E	MDA-MB-175-VII	breast	COSMIC	LQTPTSS	DEG_SCF_FBW7_1	0.25
p.R3820Q	SIDM01112	Osteosarcoma	GDSC	LQTPTSS	DEG_SCF_FBW7_1	0.2778
p.E3817V	ACH-000900	Lung Cancer	CCLE	LQTPTSS	DEG_SCF_FBW7_1	0.7693
p.E3817V	NCI-H23	lung	COSMIC	LQTPTSS	DEG_SCF_FBW7_1	0.7693
p.A3819D	H513	pleura	COSMIC	LQTPTSS	DEG_SCF_FBW7_1	0.3056
p.N3821K	H3255	lung	COSMIC	LQTPTSS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01484	Ankyrin-2	DEG_SCF_FBW7_1	3812:3818	LQTPTSS	FBXW7	0.9751	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons