DegronMD

Uniprot ID: Q01484

Source protein: Ankyrin-2

Source gene: ANK2

Class: DEG_SCF_FBW7_1

Location: 3080:3087

E3 ligase: FBXW7

DEGRON score: 0.717

ASA_SCORE: 97.05

COIL: 0.9525

CONS_SCORE: 0.4679

DSS_SCORE: 0.8721

HELIX: 0.0125

FCONS_SCORE: 1.0928

RIG_SCORE: 0.6195

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q3076L	TCGA-17-Z021	LUAD	TCGA	PDTTPART	DEG_SCF_FBW7_1	0.2222
p.Q3076L	TCGA-17-Z031	LUAD	TCGA	PDTTPART	DEG_SCF_FBW7_1	0.2222
p.P3094Q	TCGA-49-4505	LUAD	TCGA	PDTTPART	DEG_SCF_FBW7_1	0.1389
p.P3094Q	DO25498	LUAD	ICGC	PDTTPART	DEG_SCF_FBW7_1	0.1389
p.D3081E	TCGA-R6-A6KZ	ESCA	TCGA	PDTTPART	DEG_SCF_FBW7_1	0.5647
p.P3080H	DO230530	LUSC	ICGC	PDTTPART	DEG_SCF_FBW7_1	0.7694
p.G3077V	DO231169	LUSC	ICGC	PDTTPART	DEG_SCF_FBW7_1	0.25
p.T3083N	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	PDTTPART	DEG_SCF_FBW7_1	0.8166
p.T3083N	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	PDTTPART	DEG_SCF_FBW7_1	0.8166
p.S3096G	SIDM00633	Breast Carcinoma	GDSC	PDTTPART	DEG_SCF_FBW7_1	0.0833
p.S3096G	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PDTTPART	DEG_SCF_FBW7_1	0.0833
p.T3095S	SIDM01146	Gastric Carcinoma	GDSC	PDTTPART	DEG_SCF_FBW7_1	0.1111
p.T3095S	NCI-SNU-1	stomach	COSMIC	PDTTPART	DEG_SCF_FBW7_1	0.1111
p.T3079A	ACH-000589	Lung Cancer	CCLE	PDTTPART	DEG_SCF_FBW7_1	0.75
p.T3079A	NCI-H1437	lung	COSMIC	PDTTPART	DEG_SCF_FBW7_1	0.75
p.M3078T	ACH-000909	Endometrial/Uterine Cancer	CCLE	PDTTPART	DEG_SCF_FBW7_1	0.2778
p.E3094K	ACH-000910	Breast Cancer	CCLE	PDTTPART	DEG_SCF_FBW7_1	0.1389
p.E3094K	MDA-MB-453	breast	COSMIC	PDTTPART	DEG_SCF_FBW7_1	0.1389
p.S3081T	ACH-000916	Lung Cancer	CCLE	PDTTPART	DEG_SCF_FBW7_1	0.7116
p.S3081T	NCI-H1573	lung	COSMIC	PDTTPART	DEG_SCF_FBW7_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01484	Ankyrin-2	DEG_SCF_FBW7_1	3080:3087	PDTTPART	FBXW7	0.717	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons