DegronMD

Uniprot ID: Q01484

Source protein: Ankyrin-2

Source gene: ANK2

Class: DEG_Kelch_Keap1_1

Location: 2573:2578

E3 ligase: KEAP1

DEGRON score: 0.8674

ASA_SCORE: 97.9667

COIL: 0.816

CONS_SCORE: 0.3796

DSS_SCORE: 0.6211

HELIX: 0.1528

FCONS_SCORE: 0.919

RIG_SCORE: 0.6489

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2563V	TCGA-AA-3510	COAD	TCGA	DSENGE	DEG_Kelch_Keap1_1	0.0556
p.A2563V	DO7783	COAD	ICGC	DSENGE	DEG_Kelch_Keap1_1	0.0556
p.H2566R	TCGA-BR-4361	STAD	TCGA	DSENGE	DEG_Kelch_Keap1_1	0.1389
p.H2566R	DO38887	STAD	ICGC	DSENGE	DEG_Kelch_Keap1_1	0.1389
p.E2586K	TCGA-DA-A1IC	SKCM	TCGA	DSENGE	DEG_Kelch_Keap1_1	0.1111
p.E2586K	DO37430	SKCM	ICGC	DSENGE	DEG_Kelch_Keap1_1	0.1111
p.C2568G	TCGA-HV-A5A5	PAAD	TCGA	DSENGE	DEG_Kelch_Keap1_1	0.1944
p.C2568G	DO223708	PAAD	ICGC	DSENGE	DEG_Kelch_Keap1_1	0.1944
p.D2573N	TCGA-J2-A4AD	LUAD	TCGA	DSENGE	DEG_Kelch_Keap1_1	0.5821
p.D2573N	DO23915	LUAD	ICGC	DSENGE	DEG_Kelch_Keap1_1	0.5821
p.V2564L	DO229019	LICA	ICGC	DSENGE	DEG_Kelch_Keap1_1	0.0833
p.N2576K	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	DSENGE	DEG_Kelch_Keap1_1	0.6918
p.N2576K	LCLC-103H	lung	COSMIC	DSENGE	DEG_Kelch_Keap1_1	0.6918
p.Q2584L	ACH-000884	Skin Cancer	CCLE	DSENGE	DEG_Kelch_Keap1_1	0.1667
p.Q2584L	ACH-002159	Skin Cancer	CCLE	DSENGE	DEG_Kelch_Keap1_1	0.1667
p.Q2584L	M14	skin	COSMIC	DSENGE	DEG_Kelch_Keap1_1	0.1667
p.R2576M	ACH-000988	Endometrial/Uterine Cancer	CCLE	DSENGE	DEG_Kelch_Keap1_1	0.8632
p.R2576M	MFE-319	endometrium	COSMIC	DSENGE	DEG_Kelch_Keap1_1	0.8632

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01484	Ankyrin-2	DEG_Kelch_Keap1_1	2573:2578	DSENGE	KEAP1	0.8674	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons