DegronMD

Uniprot ID: Q01484

Source protein: Ankyrin-2

Source gene: ANK2

Class: DEG_SCF_FBW7_2

Location: 3084:3091

E3 ligase: FBXW7

DEGRON score: 0.6128

ASA_SCORE: 104.1125

COIL: 0.9395

CONS_SCORE: 0.4356

DSS_SCORE: 0.89

HELIX: 0.0211

FCONS_SCORE: 0.9866

RIG_SCORE: 0.6225

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q3076L	TCGA-17-Z021	LUAD	TCGA	PARTPTEE	DEG_SCF_FBW7_2	0.1111
p.Q3076L	TCGA-17-Z031	LUAD	TCGA	PARTPTEE	DEG_SCF_FBW7_2	0.1111
p.P3094Q	TCGA-49-4505	LUAD	TCGA	PARTPTEE	DEG_SCF_FBW7_2	0.25
p.P3094Q	DO25498	LUAD	ICGC	PARTPTEE	DEG_SCF_FBW7_2	0.25
p.P3088A	TCGA-DD-A4NV	LIHC	TCGA	PARTPTEE	DEG_SCF_FBW7_2	0.7503
p.P3088A	DO44876	LIHC	ICGC	PARTPTEE	DEG_SCF_FBW7_2	0.7503
p.P3100R	TCGA-OR-A5KB	ACC	TCGA	PARTPTEE	DEG_SCF_FBW7_2	0.0833
p.G3077V	DO231169	LUSC	ICGC	PARTPTEE	DEG_SCF_FBW7_2	0.1389
p.P3100L	DO220852	MELA	ICGC	PARTPTEE	DEG_SCF_FBW7_2	0.0833
p.P3088T	SIDM00120	Prostate Carcinoma	GDSC	PARTPTEE	DEG_SCF_FBW7_2	0.7031
p.P3088T	DU-145	prostate	COSMIC	PARTPTEE	DEG_SCF_FBW7_2	0.7031
p.S3096G	SIDM00633	Breast Carcinoma	GDSC	PARTPTEE	DEG_SCF_FBW7_2	0.1944
p.S3096G	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PARTPTEE	DEG_SCF_FBW7_2	0.1944
p.T3095S	SIDM01146	Gastric Carcinoma	GDSC	PARTPTEE	DEG_SCF_FBW7_2	0.2222
p.T3095S	NCI-SNU-1	stomach	COSMIC	PARTPTEE	DEG_SCF_FBW7_2	0.2222
p.N3099S	SIDM00217	Colorectal Carcinoma	GDSC	PARTPTEE	DEG_SCF_FBW7_2	0.1111
p.N3099S	SNU-1040	large_intestine	COSMIC	PARTPTEE	DEG_SCF_FBW7_2	0.1111
p.T3079A	ACH-000589	Lung Cancer	CCLE	PARTPTEE	DEG_SCF_FBW7_2	0.6389
p.T3079A	NCI-H1437	lung	COSMIC	PARTPTEE	DEG_SCF_FBW7_2	0.6389
p.M3078T	ACH-000909	Endometrial/Uterine Cancer	CCLE	PARTPTEE	DEG_SCF_FBW7_2	0.1667
p.E3094K	ACH-000910	Breast Cancer	CCLE	PARTPTEE	DEG_SCF_FBW7_2	0.25
p.E3094K	MDA-MB-453	breast	COSMIC	PARTPTEE	DEG_SCF_FBW7_2	0.25
p.Q3100K	BHY	upper_aerodigestive_tract	COSMIC	PARTPTEE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01484	Ankyrin-2	DEG_SCF_FBW7_2	3084:3091	PARTPTEE	FBXW7	0.6128	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons