DegronMD

Uniprot ID: Q01484

Source protein: Ankyrin-2

Source gene: ANK2

Class: DEG_APCC_KENBOX_2

Location: 1406:1410

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8816

ASA_SCORE: 75.72

COIL: 0.7448

CONS_SCORE: 0.6932

DSS_SCORE: 0.0384

HELIX: 0.06

FCONS_SCORE: 1.2032

RIG_SCORE: 0.8593

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1396D	TCGA-68-A59J	LUSC	TCGA	FKENR	DEG_APCC_KENBOX_2	0.0556
p.G1396D	DO49085	LUSC	ICGC	FKENR	DEG_APCC_KENBOX_2	0.0556
p.R1418C	TCGA-AA-3684	COAD	TCGA	FKENR	DEG_APCC_KENBOX_2	0.1111
p.R1418C	TCGA-FI-A2D0	UCEC	TCGA	FKENR	DEG_APCC_KENBOX_2	0.1111
p.R1418C	DO8802	COAD	ICGC	FKENR	DEG_APCC_KENBOX_2	0.1111
p.R1418C	DO43891	UCEC	ICGC	FKENR	DEG_APCC_KENBOX_2	0.1111
p.E1408K	TCGA-AC-A23H	BRCA	TCGA	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E1408K	TCGA-EE-A2M5	SKCM	TCGA	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E1408K	DO2401	BRCA	ICGC	FKENR	DEG_APCC_KENBOX_2	0.7022
p.E1408K	DO37425	SKCM	ICGC	FKENR	DEG_APCC_KENBOX_2	0.7022
p.K1407E	TCGA-EM-A3OA	THCA	TCGA	FKENR	DEG_APCC_KENBOX_2	0.7022
p.K1407E	DO48161	THCA	ICGC	FKENR	DEG_APCC_KENBOX_2	0.7022
p.R1418H	TCGA-VQ-A8PT	STAD	TCGA	FKENR	DEG_APCC_KENBOX_2	0.1111
p.R1418H	DO51776	STAD	ICGC	FKENR	DEG_APCC_KENBOX_2	0.1111
p.D1419N	DO234230	ESAD	ICGC	FKENR	DEG_APCC_KENBOX_2	0.0833
p.D1419Y	DO229029	LICA	ICGC	FKENR	DEG_APCC_KENBOX_2	0.0833
p.V1415F	DO229041	LICA	ICGC	FKENR	DEG_APCC_KENBOX_2	0.1944
p.N1409K	DO229208	THCA	ICGC	FKENR	DEG_APCC_KENBOX_2	0.6918
p.L1411F	SIDM01141	Ovarian Carcinoma	GDSC	FKENR	DEG_APCC_KENBOX_2	0.3056
p.L1411F	OV-90	ovary	COSMIC	FKENR	DEG_APCC_KENBOX_2	0.3056
p.D1419E	SIDM00282	Colorectal Carcinoma	GDSC	FKENR	DEG_APCC_KENBOX_2	0.0833
p.D1419E	CW-2	large_intestine	COSMIC	FKENR	DEG_APCC_KENBOX_2	0.0833
p.L1402F	OV-90	ovary	COSMIC	FKENR	DEG_APCC_KENBOX_2	0.6667
p.D1410E	CW-2	large_intestine	COSMIC	FKENR	DEG_APCC_KENBOX_2	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01484	Ankyrin-2	DEG_APCC_KENBOX_2	1406:1410	FKENR	APC,CDC20,FZR1	0.8816	More...
Q12955	Ankyrin-3	DEG_APCC_KENBOX_2	1390:1394	FKENR	APC,CDC20,FZR1	0.9806	More...
Q66GS9	Centrosomal protein of 135 kDa	DEG_APCC_KENBOX_2	817:821	FKENR	APC,CDC20,FZR1	0.5975	More...
Q92953	Potassium voltage-gated channel subfamily B member 2	DEG_APCC_KENBOX_2	719:723	FKENR	APC,CDC20,FZR1	0.514	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons