DegronMD - Q92953(KCNB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S712F	TCGA-18-3409	LUSC	TCGA	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation rewiring degron network	0.1389
p.S712F	DO26444	LUSC	ICGC	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation rewiring degron network	0.1389
p.S850N	TCGA-55-7576	LUAD	TCGA	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.3056
p.S850N	DO24431	LUAD	ICGC	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.3056
p.T740S	TCGA-55-7994	LUAD	TCGA	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation rewiring degron network	0.1389
p.T740S	DO45311	LUAD	ICGC	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation rewiring degron network	0.1389
p.Q728H	TCGA-63-A5MJ	LUSC	TCGA	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation altering degron motif	0.647
p.Q728H	DO219149	LUSC	ICGC	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation altering degron motif	0.647
p.S853F	TCGA-A5-A0G2	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation altering degron motif	0.7982
p.S853F	DO41235	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation altering degron motif	0.7982
p.S712T	TCGA-AZ-4315	COAD	TCGA	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation rewiring degron network	0.1389
p.S712T	DO8842	COAD	ICGC	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation rewiring degron network	0.1389
p.S854F	TCGA-CA-6717	COAD	TCGA	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation altering degron motif	0.7982
p.S854F	DO8264	COAD	ICGC	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation altering degron motif	0.7982
p.A726V	TCGA-CK-5916	COAD	TCGA	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation rewiring degron network	0.25
p.A726V	TCGA-CK-5916	COAD	TCGA	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation rewiring degron network	0.3056
p.A726V	DO8786	COAD	ICGC	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation rewiring degron network	0.25
p.A726V	DO8786	COAD	ICGC	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation rewiring degron network	0.3056
p.R842K	TCGA-CR-6481	HNSC	TCGA	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.0833
p.R842K	DO14990	HNSC	ICGC	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.0833
p.E721K	TCGA-D3-A2JL	SKCM	TCGA	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.7022
p.E721K	TCGA-EB-A3Y7	SKCM	TCGA	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.7022
p.E721K	TCGA-EB-A6QZ	SKCM	TCGA	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.7022
p.E721K	TCGA-ER-A19M	SKCM	TCGA	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.7022
p.E721K	DO222363	MELA	ICGC	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.7022
p.E721K	DO222837	MELA	ICGC	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.7022
p.E721K	DO219879	SKCA	ICGC	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.7022
p.E721K	DO47278	SKCM	ICGC	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.7022
p.E721K	DO37798	SKCM	ICGC	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.7022
p.E721K	DO37499	SKCM	ICGC	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.7022
p.E721K	DO48626	SKCM	ICGC	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.7022
p.E721K	SIDM00568	Gastric Carcinoma	GDSC	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.7022
p.E721K	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.7022
p.E721K	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.7022
p.E721K	ACH-000247	Gastric Cancer	CCLE	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.7022
p.E721K	ACH-000553	Lung Cancer	CCLE	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.7022
p.E721K	ACH-000813	Lung Cancer	CCLE	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.7022
p.E721K	OCUM-1	stomach	COSMIC	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.7022
p.T733I	TCGA-D3-A8GO	SKCM	TCGA	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation altering degron motif	0.8189
p.T733I	DO51242	SKCM	ICGC	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation altering degron motif	0.8189
p.P844L	TCGA-D3-A8GQ	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1389
p.P844L	DO51246	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1389
p.P736S	TCGA-DD-AACZ	LIHC	TCGA	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation rewiring degron network	0.25
p.P736S	DO52216	LIHC	ICGC	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation rewiring degron network	0.25
p.P736S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation rewiring degron network	0.25
p.P736S	ACH-002059	Leukemia	CCLE	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation rewiring degron network	0.25
p.P736S	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation rewiring degron network	0.25
p.G841R	TCGA-EE-A2GD	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.0556
p.G841R	DO37603	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.0556
p.G849D	TCGA-EE-A2GO	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.2778
p.G849D	DO37823	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.2778
p.P856S	TCGA-W3-AA1V	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.3056
p.P856S	DO51276	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.3056
p.P844S	TCGA-XF-AAN7	BLCA	TCGA	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1389
p.P844S	DO51946	BLCA	ICGC	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1389
p.V739F	DO224957	BRCA	ICGC	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation rewiring degron network	0.1667
p.T729I	DO222404	BTCA	ICGC	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation altering degron motif	0.7078
p.R723G	DO233818	GACA	ICGC	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.6457
p.N862K	DO228204	LICA	ICGC	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1389
p.A734S	DO229009	LICA	ICGC	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation rewiring degron network	0.3056
p.K720M	DO231722	LINC	ICGC	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation altering degron motif	0.8062
p.P731R	DO45117	LIRI	ICGC	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation altering degron motif	0.6401
p.D858Y	DO45107	LIRI	ICGC	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.25
p.E848K	DO222702	MELA	ICGC	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.25
p.T740I	DO222847	MELA	ICGC	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation rewiring degron network	0.1389
p.P730L	DO35737	PBCA	ICGC	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation altering degron motif	0.7582
p.A734T	DO229459	SKCA	ICGC	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation rewiring degron network	0.3056
p.G724A	SIDM00845	Burkitt's Lymphoma	GDSC	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation rewiring degron network	0.3056
p.G724A	SIDM00845	Burkitt's Lymphoma	GDSC	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation rewiring degron network	0.25
p.S714F	SIDM00974	Melanoma	GDSC	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation blocking phosphorylation signal	0.6389
p.S714F	WM35	skin	COSMIC	FKENR	DEG_APCC_KENBOX_2	719:723	Mutation blocking phosphorylation signal	0.6389
p.S853P	SIDM00877	Breast Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation altering degron motif	0.6752
p.S853P	ACH-000196	Breast Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation altering degron motif	0.6752
p.S853P	HCC1599	breast	COSMIC	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation altering degron motif	0.6752
p.P730S	ACH-001814	Bone Cancer	CCLE	PQTPPST	DEG_SCF_FBW7_1	727:733	Mutation altering degron motif	0.6752
p.G860S	ACH-001982	Metastasis	CCLE	VGSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1944

Kaplan plot for KCNB2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNB2

UniProt ID: Q92953

Entrez ID: 9312

Protein name: Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNB2 in