DegronMD

Uniprot ID: Q92953

Source protein: Potassium voltage-gated channel subfamily B member 2

Source gene: KCNB2

Class: DEG_SCF_FBW7_1

Location: 727:733

E3 ligase: FBXW7

DEGRON score: 0.9597

ASA_SCORE: 82.6857

COIL: 0.893

CONS_SCORE: 0.3176

DSS_SCORE: 0.7352

HELIX: 0.0526

FCONS_SCORE: 1.0866

RIG_SCORE: 0.5888

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T740S	TCGA-55-7994	LUAD	TCGA	PQTPPST	DEG_SCF_FBW7_1	0.1389
p.T740S	DO45311	LUAD	ICGC	PQTPPST	DEG_SCF_FBW7_1	0.1389
p.Q728H	TCGA-63-A5MJ	LUSC	TCGA	PQTPPST	DEG_SCF_FBW7_1	0.647
p.Q728H	DO219149	LUSC	ICGC	PQTPPST	DEG_SCF_FBW7_1	0.647
p.A726V	TCGA-CK-5916	COAD	TCGA	PQTPPST	DEG_SCF_FBW7_1	0.3056
p.A726V	DO8786	COAD	ICGC	PQTPPST	DEG_SCF_FBW7_1	0.3056
p.T733I	TCGA-D3-A8GO	SKCM	TCGA	PQTPPST	DEG_SCF_FBW7_1	0.8189
p.T733I	DO51242	SKCM	ICGC	PQTPPST	DEG_SCF_FBW7_1	0.8189
p.P736S	TCGA-DD-AACZ	LIHC	TCGA	PQTPPST	DEG_SCF_FBW7_1	0.25
p.P736S	DO52216	LIHC	ICGC	PQTPPST	DEG_SCF_FBW7_1	0.25
p.P736S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PQTPPST	DEG_SCF_FBW7_1	0.25
p.P736S	ACH-002059	Leukemia	CCLE	PQTPPST	DEG_SCF_FBW7_1	0.25
p.P736S	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	PQTPPST	DEG_SCF_FBW7_1	0.25
p.V739F	DO224957	BRCA	ICGC	PQTPPST	DEG_SCF_FBW7_1	0.1667
p.T729I	DO222404	BTCA	ICGC	PQTPPST	DEG_SCF_FBW7_1	0.7078
p.A734S	DO229009	LICA	ICGC	PQTPPST	DEG_SCF_FBW7_1	0.3056
p.P731R	DO45117	LIRI	ICGC	PQTPPST	DEG_SCF_FBW7_1	0.6401
p.T740I	DO222847	MELA	ICGC	PQTPPST	DEG_SCF_FBW7_1	0.1389
p.P730L	DO35737	PBCA	ICGC	PQTPPST	DEG_SCF_FBW7_1	0.7582
p.A734T	DO229459	SKCA	ICGC	PQTPPST	DEG_SCF_FBW7_1	0.3056
p.G724A	SIDM00845	Burkitt's Lymphoma	GDSC	PQTPPST	DEG_SCF_FBW7_1	0.25
p.P730S	ACH-001814	Bone Cancer	CCLE	PQTPPST	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92953	Potassium voltage-gated channel subfamily B member 2	DEG_SCF_FBW7_1	727:733	PQTPPST	FBXW7	0.9597	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons