DegronMD

Uniprot ID: Q92953

Source protein: Potassium voltage-gated channel subfamily B member 2

Source gene: KCNB2

Class: DEG_SPOP_SBC_1

Location: 851:855

E3 ligase: SPOP

DEGRON score: 0.9618

ASA_SCORE: 69.42

COIL: 0.916

CONS_SCORE: 0.3053

DSS_SCORE: 0.7172

HELIX: 0.0254

FCONS_SCORE: 1.0107

RIG_SCORE: 0.5164

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S850N	TCGA-55-7576	LUAD	TCGA	VGSSS	DEG_SPOP_SBC_1	0.3056
p.S850N	DO24431	LUAD	ICGC	VGSSS	DEG_SPOP_SBC_1	0.3056
p.S853F	TCGA-A5-A0G2	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	0.7982
p.S853F	DO41235	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	0.7982
p.S854F	TCGA-CA-6717	COAD	TCGA	VGSSS	DEG_SPOP_SBC_1	0.7982
p.S854F	DO8264	COAD	ICGC	VGSSS	DEG_SPOP_SBC_1	0.7982
p.R842K	TCGA-CR-6481	HNSC	TCGA	VGSSS	DEG_SPOP_SBC_1	0.0833
p.R842K	DO14990	HNSC	ICGC	VGSSS	DEG_SPOP_SBC_1	0.0833
p.P844L	TCGA-D3-A8GQ	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	0.1389
p.P844L	DO51246	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	0.1389
p.G841R	TCGA-EE-A2GD	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	0.0556
p.G841R	DO37603	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	0.0556
p.G849D	TCGA-EE-A2GO	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	0.2778
p.G849D	DO37823	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	0.2778
p.P856S	TCGA-W3-AA1V	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	0.3056
p.P856S	DO51276	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	0.3056
p.P844S	TCGA-XF-AAN7	BLCA	TCGA	VGSSS	DEG_SPOP_SBC_1	0.1389
p.P844S	DO51946	BLCA	ICGC	VGSSS	DEG_SPOP_SBC_1	0.1389
p.N862K	DO228204	LICA	ICGC	VGSSS	DEG_SPOP_SBC_1	0.1389
p.D858Y	DO45107	LIRI	ICGC	VGSSS	DEG_SPOP_SBC_1	0.25
p.E848K	DO222702	MELA	ICGC	VGSSS	DEG_SPOP_SBC_1	0.25
p.S853P	SIDM00877	Breast Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.6752
p.S853P	ACH-000196	Breast Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	0.6752
p.S853P	HCC1599	breast	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.6752
p.G860S	ACH-001982	Metastasis	CCLE	VGSSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94972	E3 ubiquitin-protein ligase TRIM37	DEG_SPOP_SBC_1	591:595	VGSSS	SPOP	0.7449	More...
P25025	C-X-C chemokine receptor type 2	DEG_SPOP_SBC_1	349:353	VGSSS	SPOP	0.8617	More...
Q05469	Hormone-sensitive lipase	DEG_SPOP_SBC_1	238:242	VGSSS	SPOP	0.9766	More...
Q15149	Plectin	DEG_SPOP_SBC_1	4387:4391	VGSSS	SPOP	0.9829	More...
Q5SXH7	Pleckstrin homology domain-containing family S member 1	DEG_SPOP_SBC_1	166:170	VGSSS	SPOP	0.9981	More...
Q5T5Y3	Calmodulin-regulated spectrin-associated protein 1	DEG_SPOP_SBC_1	1208:1212	VGSSS	SPOP	0.9095	More...
Q5VST9	Obscurin	DEG_SPOP_SBC_1	2777:2781	VGSSS	SPOP	0.6097	More...
Q6GQQ9	OTU domain-containing protein 7B	DEG_SPOP_SBC_1	472:476	VGSSS	SPOP	0.9978	More...
Q6IMN6	Caprin-2	DEG_SPOP_SBC_1	603:607	VGSSS	SPOP	0.9899	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1871:1875	VGSSS	SPOP	0.9665	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	297:301	VGSSS	SPOP	0.9039	More...
Q92953	Potassium voltage-gated channel subfamily B member 2	DEG_SPOP_SBC_1	851:855	VGSSS	SPOP	0.9618	More...
Q99569	Plakophilin-4	DEG_SPOP_SBC_1	333:337	VGSSS	SPOP	0.9838	More...
Q99590	Protein SCAF11	DEG_SPOP_SBC_1	470:474	VGSSS	SPOP	0.9942	More...
Q9BSE4	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein	DEG_SPOP_SBC_1	134:138	VGSSS	SPOP	0.9842	More...
Q9H5N1	Rab GTPase-binding effector protein 2	DEG_SPOP_SBC_1	243:247	VGSSS	SPOP	0.9275	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	754:758	VGSSS	SPOP	0.9976	More...
Q9HAK2	Transcription factor COE2	DEG_SPOP_SBC_1	517:521	VGSSS	SPOP	0.9803	More...
Q9UHD9	Ubiquilin-2	DEG_SPOP_SBC_1	295:299	VGSSS	SPOP	0.9306	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1440:1444	VGSSS	SPOP	0.9873	More...
Q9UPZ9	Serine/threonine-protein kinase ICK	DEG_SPOP_SBC_1	541:545	VGSSS	SPOP	0.9539	More...
Q9UQR1	Zinc finger protein 148	DEG_SPOP_SBC_1	587:591	VGSSS	SPOP	0.95	More...
Q9Y6H8	Gap junction alpha-3 protein	DEG_SPOP_SBC_1	355:359	VGSSS	SPOP	0.9829	More...
Q9Y6V0	Protein piccolo	DEG_SPOP_SBC_1	1533:1537	VGSSS	SPOP	0.9666	More...
A6NEL2	Ankyrin repeat domain-containing protein SOWAHB	DEG_SPOP_SBC_1	738:742	VGSSS	SPOP	0.9911	More...
Q14582	Max dimerization protein 4	DEG_SPOP_SBC_1	174:178	VGSSS	SPOP	0.9872	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1545:1549	VGSSS	SPOP	0.8639	More...
Q8N5Q1	Golgi associated RAB2 interactor protein 5B	DEG_SPOP_SBC_1	869:873	VGSSS	SPOP	0.7404	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGSSS

Degron related mutations and impact score

Drug responses associated with KCNB2 mutations

All proteins holding degron of VGSSS