DegronMD - Q9H5N1(RABEP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G244S	TCGA-CV-6942	HNSC	TCGA	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.5882
p.G244S	DO15951	HNSC	ICGC	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.5882
p.S248F	TCGA-EE-A2GU	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.3056
p.S248F	DO37639	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.3056
p.G242V	TCGA-EE-A3AA	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.3056
p.G242V	TCGA-EL-A3TB	THCA	TCGA	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.3056
p.G242V	DO37571	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.3056
p.G242V	DO38901	THCA	ICGC	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.3056
p.W292L	TCGA-ER-A196	SKCM	TCGA	PPGY	ITCH	281:284	Mutation rewiring degron network	0.1111
p.W292L	DO47474	SKCM	ICGC	PPGY	ITCH	281:284	Mutation rewiring degron network	0.1111
p.V243F	TCGA-FJ-A3ZE	BLCA	TCGA	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.7068
p.V243F	DO484	BLCA	ICGC	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.7068
p.I234V	TCGA-S9-A6TX	LGG	TCGA	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.0833
p.I234V	DO50184	LGG	ICGC	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.0833
p.S252R	TCGA-X6-A7WA	SARC	TCGA	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1944
p.S252R	DO220312	SARC	ICGC	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1944
p.S246N	DO233276	GACA	ICGC	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.7069
p.L256P	DO233882	GACA	ICGC	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.0833
p.L286F	DO228961	LICA	ICGC	PPGY	ITCH	281:284	Mutation rewiring degron network	0.2778
p.D289E	DO229025	LICA	ICGC	PPGY	ITCH	281:284	Mutation rewiring degron network	0.1944
p.R253H	DO229194	LMS	ICGC	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.1667
p.P274S	DO220882	MELA	ICGC	PPGY	ITCH	281:284	Mutation rewiring degron network	0.1389
p.P274S	DO229459	SKCA	ICGC	PPGY	ITCH	281:284	Mutation rewiring degron network	0.1389
p.P274S	SIDM00973	Melanoma	GDSC	PPGY	ITCH	281:284	Mutation rewiring degron network	0.1389
p.P274S	ACH-000827	Skin Cancer	CCLE	PPGY	ITCH	281:284	Mutation rewiring degron network	0.1389
p.P274S	WM793B	skin	COSMIC	PPGY	ITCH	281:284	Mutation rewiring degron network	0.1389
p.L256R	DO35442	PACA	ICGC	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.0833
p.P274L	DO229459	SKCA	ICGC	PPGY	ITCH	281:284	Mutation rewiring degron network	0.1389
p.S257I	DO229264	THCA	ICGC	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation blocking phosphorylation signal	0.5
p.S245N	DO229221	THCA	ICGC	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation altering degron motif	0.7069
p.Y284H	DO229224	THCA	ICGC	PPGY	ITCH	281:284	Mutation altering degron motif	0.7229
p.S257R	SIDM00334	Endometrial Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation blocking phosphorylation signal	0.5
p.S257R	ACH-000879	Endometrial/Uterine Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation blocking phosphorylation signal	0.5
p.S257R	MFE-296	endometrium	COSMIC	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation blocking phosphorylation signal	0.5
p.I277V	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	281:284	Mutation rewiring degron network	0.2222
p.I277V	ACH-000951	Lung Cancer	CCLE	PPGY	ITCH	281:284	Mutation rewiring degron network	0.2222
p.I277V	NCI-H2342	lung	COSMIC	PPGY	ITCH	281:284	Mutation rewiring degron network	0.2222
p.P282A	SIDM00622	Glioblastoma	GDSC	PPGY	ITCH	281:284	Mutation altering degron motif	0.7503
p.P282A	ACH-002224	Brain Cancer	CCLE	PPGY	ITCH	281:284	Mutation altering degron motif	0.7503
p.P282A	D-247MG	central nervous system	COSMIC	PPGY	ITCH	281:284	Mutation altering degron motif	0.7503
p.P250S	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.25
p.P250S	JVM-2	haematopoietic and lymphoid tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.25
p.R287W	KYSE-150	oesophagus	COSMIC	PPGY	ITCH	281:284	Mutation rewiring degron network	0.25
p.R251Q	STS-0421	soft tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.2222
p.R240H	NCI-H128	lung	COSMIC	VGSSS	DEG_SPOP_SBC_1	243:247	Mutation rewiring degron network	0.25
p.R275Q	HCC202	breast	COSMIC	PPGY	ITCH	281:284	Mutation rewiring degron network	0.1667

Kaplan plot for RABEP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RABEP2

UniProt ID: Q9H5N1

Entrez ID: 79874

Protein name: Rab GTPase-binding effector protein 2 (Rabaptin-5beta)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RABEP2 in