DegronMD

Uniprot ID: Q9H5N1

Source protein: Rab GTPase-binding effector protein 2

Source gene: RABEP2

Class: DEG_SPOP_SBC_1

Location: 243:247

E3 ligase: SPOP

DEGRON score: 0.9275

ASA_SCORE: 75.82

COIL: 0.8502

CONS_SCORE: 0.2834

DSS_SCORE: 0.5202

HELIX: 0.0866

FCONS_SCORE: 0.7355

RIG_SCORE: 0.5497

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G244S	TCGA-CV-6942	HNSC	TCGA	VGSSS	DEG_SPOP_SBC_1	0.5882
p.G244S	DO15951	HNSC	ICGC	VGSSS	DEG_SPOP_SBC_1	0.5882
p.S248F	TCGA-EE-A2GU	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	0.3056
p.S248F	DO37639	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	0.3056
p.G242V	TCGA-EE-A3AA	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	0.3056
p.G242V	TCGA-EL-A3TB	THCA	TCGA	VGSSS	DEG_SPOP_SBC_1	0.3056
p.G242V	DO37571	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	0.3056
p.G242V	DO38901	THCA	ICGC	VGSSS	DEG_SPOP_SBC_1	0.3056
p.V243F	TCGA-FJ-A3ZE	BLCA	TCGA	VGSSS	DEG_SPOP_SBC_1	0.7068
p.V243F	DO484	BLCA	ICGC	VGSSS	DEG_SPOP_SBC_1	0.7068
p.I234V	TCGA-S9-A6TX	LGG	TCGA	VGSSS	DEG_SPOP_SBC_1	0.0833
p.I234V	DO50184	LGG	ICGC	VGSSS	DEG_SPOP_SBC_1	0.0833
p.S252R	TCGA-X6-A7WA	SARC	TCGA	VGSSS	DEG_SPOP_SBC_1	0.1944
p.S252R	DO220312	SARC	ICGC	VGSSS	DEG_SPOP_SBC_1	0.1944
p.S246N	DO233276	GACA	ICGC	VGSSS	DEG_SPOP_SBC_1	0.7069
p.L256P	DO233882	GACA	ICGC	VGSSS	DEG_SPOP_SBC_1	0.0833
p.R253H	DO229194	LMS	ICGC	VGSSS	DEG_SPOP_SBC_1	0.1667
p.L256R	DO35442	PACA	ICGC	VGSSS	DEG_SPOP_SBC_1	0.0833
p.S257I	DO229264	THCA	ICGC	VGSSS	DEG_SPOP_SBC_1	0.5
p.S245N	DO229221	THCA	ICGC	VGSSS	DEG_SPOP_SBC_1	0.7069
p.S257R	SIDM00334	Endometrial Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.5
p.S257R	ACH-000879	Endometrial/Uterine Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	0.5
p.S257R	MFE-296	endometrium	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.5
p.P250S	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.25
p.P250S	JVM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.25
p.R251Q	STS-0421	soft_tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.2222
p.R240H	NCI-H128	lung	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94972	E3 ubiquitin-protein ligase TRIM37	DEG_SPOP_SBC_1	591:595	VGSSS	SPOP	0.7449	More...
P25025	C-X-C chemokine receptor type 2	DEG_SPOP_SBC_1	349:353	VGSSS	SPOP	0.8617	More...
Q05469	Hormone-sensitive lipase	DEG_SPOP_SBC_1	238:242	VGSSS	SPOP	0.9766	More...
Q15149	Plectin	DEG_SPOP_SBC_1	4387:4391	VGSSS	SPOP	0.9829	More...
Q5SXH7	Pleckstrin homology domain-containing family S member 1	DEG_SPOP_SBC_1	166:170	VGSSS	SPOP	0.9981	More...
Q5T5Y3	Calmodulin-regulated spectrin-associated protein 1	DEG_SPOP_SBC_1	1208:1212	VGSSS	SPOP	0.9095	More...
Q5VST9	Obscurin	DEG_SPOP_SBC_1	2777:2781	VGSSS	SPOP	0.6097	More...
Q6GQQ9	OTU domain-containing protein 7B	DEG_SPOP_SBC_1	472:476	VGSSS	SPOP	0.9978	More...
Q6IMN6	Caprin-2	DEG_SPOP_SBC_1	603:607	VGSSS	SPOP	0.9899	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1871:1875	VGSSS	SPOP	0.9665	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	297:301	VGSSS	SPOP	0.9039	More...
Q92953	Potassium voltage-gated channel subfamily B member 2	DEG_SPOP_SBC_1	851:855	VGSSS	SPOP	0.9618	More...
Q99569	Plakophilin-4	DEG_SPOP_SBC_1	333:337	VGSSS	SPOP	0.9838	More...
Q99590	Protein SCAF11	DEG_SPOP_SBC_1	470:474	VGSSS	SPOP	0.9942	More...
Q9BSE4	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein	DEG_SPOP_SBC_1	134:138	VGSSS	SPOP	0.9842	More...
Q9H5N1	Rab GTPase-binding effector protein 2	DEG_SPOP_SBC_1	243:247	VGSSS	SPOP	0.9275	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	754:758	VGSSS	SPOP	0.9976	More...
Q9HAK2	Transcription factor COE2	DEG_SPOP_SBC_1	517:521	VGSSS	SPOP	0.9803	More...
Q9UHD9	Ubiquilin-2	DEG_SPOP_SBC_1	295:299	VGSSS	SPOP	0.9306	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1440:1444	VGSSS	SPOP	0.9873	More...
Q9UPZ9	Serine/threonine-protein kinase ICK	DEG_SPOP_SBC_1	541:545	VGSSS	SPOP	0.9539	More...
Q9UQR1	Zinc finger protein 148	DEG_SPOP_SBC_1	587:591	VGSSS	SPOP	0.95	More...
Q9Y6H8	Gap junction alpha-3 protein	DEG_SPOP_SBC_1	355:359	VGSSS	SPOP	0.9829	More...
Q9Y6V0	Protein piccolo	DEG_SPOP_SBC_1	1533:1537	VGSSS	SPOP	0.9666	More...
A6NEL2	Ankyrin repeat domain-containing protein SOWAHB	DEG_SPOP_SBC_1	738:742	VGSSS	SPOP	0.9911	More...
Q14582	Max dimerization protein 4	DEG_SPOP_SBC_1	174:178	VGSSS	SPOP	0.9872	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1545:1549	VGSSS	SPOP	0.8639	More...
Q8N5Q1	Golgi associated RAB2 interactor protein 5B	DEG_SPOP_SBC_1	869:873	VGSSS	SPOP	0.7404	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGSSS

Degron related mutations and impact score

Drug responses associated with RABEP2 mutations

All proteins holding degron of VGSSS