DegronMD - Q9UHD9(UBQLN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G289V	TCGA-24-1470	OV	TCGA	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation rewiring degron network	0.0833
p.G289V	TCGA-24-1470	OV	TCGA	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1667
p.G289V	DO28010	OV	ICGC	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation rewiring degron network	0.0833
p.G289V	DO28010	OV	ICGC	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1667
p.G288W	TCGA-49-AARE	LUAD	TCGA	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation rewiring degron network	0.0556
p.G288W	TCGA-49-AARE	LUAD	TCGA	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1389
p.G288W	DO218922	LUAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation rewiring degron network	0.0556
p.G288W	DO218922	LUAD	ICGC	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1389
p.Q327H	TCGA-55-7995	LUAD	TCGA	ATTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.25
p.Q327H	DO45323	LUAD	ICGC	ATTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.25
p.R309H	TCGA-AA-3672	COAD	TCGA	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation rewiring degron network	0.1667
p.R309H	TCGA-AA-3672	COAD	TCGA	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0556
p.R309H	DO9010	COAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation rewiring degron network	0.1667
p.R309H	DO9010	COAD	ICGC	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0556
p.T335S	TCGA-AX-A1CE	UCEC	TCGA	ATTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.3056
p.T335S	DO42280	UCEC	ICGC	ATTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.3056
p.P323L	TCGA-B5-A3FA	UCEC	TCGA	ATTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1389
p.P323L	DO52402	UCEC	ICGC	ATTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1389
p.R309S	TCGA-BQ-7059	KIRP	TCGA	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation rewiring degron network	0.1667
p.R309S	TCGA-BQ-7059	KIRP	TCGA	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0556
p.R309S	TCGA-E8-A2EA	THCA	TCGA	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation rewiring degron network	0.1667
p.R309S	TCGA-E8-A2EA	THCA	TCGA	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0556
p.R309S	TCGA-EM-A2OZ	THCA	TCGA	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation rewiring degron network	0.1667
p.R309S	TCGA-EM-A2OZ	THCA	TCGA	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0556
p.R309S	DO20932	KIRP	ICGC	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation rewiring degron network	0.1667
p.R309S	DO20932	KIRP	ICGC	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0556
p.R309S	DO38926	THCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation rewiring degron network	0.1667
p.R309S	DO38926	THCA	ICGC	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0556
p.R309S	DO39708	THCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation rewiring degron network	0.1667
p.R309S	DO39708	THCA	ICGC	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0556
p.G302R	TCGA-CQ-6228	HNSC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation altering degron motif	0.7568
p.G302R	DO14750	HNSC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation altering degron motif	0.7568
p.Q306L	TCGA-CV-6936	HNSC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation rewiring degron network	0.25
p.Q306L	TCGA-CV-6936	HNSC	TCGA	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1389
p.Q306L	DO14210	HNSC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation rewiring degron network	0.25
p.Q306L	DO14210	HNSC	ICGC	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1389
p.Q327K	TCGA-EE-A2MP	SKCM	TCGA	ATTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.25
p.Q327K	DO37818	SKCM	ICGC	ATTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.25
p.R313C	TCGA-EO-A22R	UCEC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation rewiring degron network	0.0556
p.R313C	DO42713	UCEC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation rewiring degron network	0.0556
p.G288V	TCGA-EY-A1GU	UCEC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation rewiring degron network	0.0556
p.G288V	TCGA-EY-A1GU	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1389
p.G288V	DO41518	UCEC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation rewiring degron network	0.0556
p.G288V	DO41518	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1389
p.A330T	DO230342	COCA	ICGC	ATTST	DEG_SPOP_SBC_1	330:334	Mutation altering degron motif	0.7139
p.G289D	DO222492	COCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation rewiring degron network	0.0833
p.G289D	DO222492	COCA	ICGC	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1667
p.V295M	DO222842	COCA	ICGC	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation altering degron motif	0.7208
p.G302W	DO228952	LICA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	298:303	Mutation altering degron motif	0.7825
p.Q286R	DO34072	PACA	ICGC	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0833
p.A330V	DO34833	PACA	ICGC	ATTST	DEG_SPOP_SBC_1	330:334	Mutation altering degron motif	0.5825
p.N344S	SIDM00411	Pancreatic Carcinoma	GDSC	ATTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.0556
p.N344S	ACH-000332	Pancreatic Cancer	CCLE	ATTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.0556
p.N344S	YAPC	pancreas	COSMIC	ATTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.0556
p.F287L	SIDM00290	Gastric Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1111
p.F287L	ACH-000847	Gastric Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1111
p.F287L	HGC-27	stomach	COSMIC	VGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1111

Kaplan plot for UBQLN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBQLN2

UniProt ID: Q9UHD9

Entrez ID: 29978

Protein name: Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UBQLN2 in