DegronMD

Uniprot ID: Q9UHD9

Source protein: Ubiquilin-2

Source gene: UBQLN2

Class: DEG_Kelch_Keap1_1

Location: 298:303

E3 ligase: KEAP1

DEGRON score: 0.9228

ASA_SCORE: 67.1

COIL: 0.8747

CONS_SCORE: 0.2425

DSS_SCORE: 0.7461

HELIX: 0.0597

FCONS_SCORE: 0.6917

RIG_SCORE: 0.4573

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G289V	TCGA-24-1470	OV	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.0833
p.G289V	DO28010	OV	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.0833
p.G288W	TCGA-49-AARE	LUAD	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.0556
p.G288W	DO218922	LUAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.0556
p.R309H	TCGA-AA-3672	COAD	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.R309H	DO9010	COAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.R309S	TCGA-BQ-7059	KIRP	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.R309S	TCGA-E8-A2EA	THCA	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.R309S	TCGA-EM-A2OZ	THCA	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.R309S	DO20932	KIRP	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.R309S	DO38926	THCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.R309S	DO39708	THCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1667
p.G302R	TCGA-CQ-6228	HNSC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.7568
p.G302R	DO14750	HNSC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.7568
p.Q306L	TCGA-CV-6936	HNSC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.25
p.Q306L	DO14210	HNSC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.25
p.R313C	TCGA-EO-A22R	UCEC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.0556
p.R313C	DO42713	UCEC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.0556
p.G288V	TCGA-EY-A1GU	UCEC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.0556
p.G288V	DO41518	UCEC	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.0556
p.G289D	DO222492	COCA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.0833
p.G302W	DO228952	LICA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.7825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43365	Homeobox protein Hox-A3	DEG_Kelch_Keap1_1	172:177	SSSSGE	KEAP1	0.9946	More...
Q13023	A-kinase anchor protein 6	DEG_Kelch_Keap1_1	326:331	SSSSGE	KEAP1	0.7982	More...
Q86YN6	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	DEG_Kelch_Keap1_1	796:801	SSSSGE	KEAP1	0.957	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_Kelch_Keap1_1	167:172	SSSSGE	KEAP1	0.5636	More...
Q92570	Nuclear receptor subfamily 4 group A member 3	DEG_Kelch_Keap1_1	284:289	SSSSGE	KEAP1	0.8454	More...
Q9P1Z0	Zinc finger and BTB domain-containing protein 4	DEG_Kelch_Keap1_1	825:830	SSSSGE	KEAP1	0.9877	More...
Q9UHD9	Ubiquilin-2	DEG_Kelch_Keap1_1	298:303	SSSSGE	KEAP1	0.9228	More...
Q2KJY2	Kinesin-like protein KIF26B	DEG_Kelch_Keap1_1	1491:1496	SSSSGE	KEAP1	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons