DegronMD

Uniprot ID: Q2KJY2

Source protein: Kinesin-like protein KIF26B

Source gene: KIF26B

Class: DEG_Kelch_Keap1_1

Location: 1491:1496

E3 ligase: KEAP1

DEGRON score: 0.997

ASA_SCORE: 72.6667

COIL: 0.7845

CONS_SCORE: 0.3467

DSS_SCORE: 0.713

HELIX: 0.0615

FCONS_SCORE: 1.0845

RIG_SCORE: 0.5443

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1495A	TCGA-85-8352	LUSC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.754
p.S1493I	TCGA-EL-A3MZ	THCA	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.7341
p.P1486Q	TCGA-IB-7651	PAAD	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.1944
p.P1484L	TCGA-LN-A8I1	ESCA	TCGA	SSSSGE	DEG_Kelch_Keap1_1	0.1389
p.C1482S	DO233855	GACA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.0833
p.S1484R	DO50940	LICA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.1389
p.T1505M	DO50417	PRAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.0833
p.D1489G	DO38404	STAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	0.2778
p.L1490F	SIDM01259	B-Lymphoblastic Leukemia	GDSC	SSSSGE	DEG_Kelch_Keap1_1	0.3056
p.L1490F	ACH-002238	Leukemia	CCLE	SSSSGE	DEG_Kelch_Keap1_1	0.3056
p.L1490F	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	SSSSGE	DEG_Kelch_Keap1_1	0.3056
p.S1498L	SIDM00963	Breast Carcinoma	GDSC	SSSSGE	DEG_Kelch_Keap1_1	0.2778
p.S1498L	ACH-000927	Breast Cancer	CCLE	SSSSGE	DEG_Kelch_Keap1_1	0.2778
p.S1498L	BT-474	breast	COSMIC	SSSSGE	DEG_Kelch_Keap1_1	0.2778
p.P1484H	SIDM00841	Colorectal Carcinoma	GDSC	SSSSGE	DEG_Kelch_Keap1_1	0.1389
p.P1484H	ACH-000651	Colon/Colorectal Cancer	CCLE	SSSSGE	DEG_Kelch_Keap1_1	0.1389
p.P1484H	SW620	large_intestine	COSMIC	SSSSGE	DEG_Kelch_Keap1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43365	Homeobox protein Hox-A3	DEG_Kelch_Keap1_1	172:177	SSSSGE	KEAP1	0.9946	More...
Q13023	A-kinase anchor protein 6	DEG_Kelch_Keap1_1	326:331	SSSSGE	KEAP1	0.7982	More...
Q86YN6	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	DEG_Kelch_Keap1_1	796:801	SSSSGE	KEAP1	0.957	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_Kelch_Keap1_1	167:172	SSSSGE	KEAP1	0.5636	More...
Q92570	Nuclear receptor subfamily 4 group A member 3	DEG_Kelch_Keap1_1	284:289	SSSSGE	KEAP1	0.8454	More...
Q9P1Z0	Zinc finger and BTB domain-containing protein 4	DEG_Kelch_Keap1_1	825:830	SSSSGE	KEAP1	0.9877	More...
Q9UHD9	Ubiquilin-2	DEG_Kelch_Keap1_1	298:303	SSSSGE	KEAP1	0.9228	More...
Q2KJY2	Kinesin-like protein KIF26B	DEG_Kelch_Keap1_1	1491:1496	SSSSGE	KEAP1	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons