DegronMD - Q2KJY2(KIF26B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G713C	TCGA-09-2044	OV	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.2778
p.G713C	TCGA-ER-A19T	SKCM	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.2778
p.R704H	TCGA-2Y-A9H6	LIHC	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation altering degron motif	0.8244
p.R704H	TCGA-AA-3655	COAD	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation altering degron motif	0.8244
p.G696V	TCGA-43-2581	LUSC	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.1389
p.E1123V	TCGA-49-AARN	LUAD	TCGA	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.1111
p.G1495A	TCGA-85-8352	LUSC	TCGA	SSSSGE	DEG_Kelch_Keap1_1	1491:1496	Mutation altering degron motif	0.754
p.G696W	TCGA-94-8490	LUSC	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.1389
p.A1114V	TCGA-AA-3949	COAD	TCGA	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation altering degron motif	0.5825
p.A1114V	TCGA-AA-3977	COAD	TCGA	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation altering degron motif	0.5825
p.A1114V	SIDM00265	Ewing's Sarcoma	GDSC	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation altering degron motif	0.5825
p.A1114V	ACH-002104	Bone Cancer	CCLE	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation altering degron motif	0.5825
p.A1114V	ES3	bone	COSMIC	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation altering degron motif	0.5825
p.R404W	TCGA-AA-A00N	COAD	TCGA	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.R404W	TCGA-VQ-A8P2	STAD	TCGA	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.R404W	SIDM00260	Gastric Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.R404W	SIDM00248	Gastric Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.R404W	ACH-000758	Gastric Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.R404W	ACH-002161	Gastric Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.R404W	MKN28	stomach	COSMIC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.P414L	TCGA-AB-2808	LAML	TCGA	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.1944
p.L1202P	TCGA-AP-A1DK	UCEC	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.3056
p.R1125H	TCGA-AX-A2HC	UCEC	TCGA	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.0556
p.S1212N	TCGA-AX-A2HC	UCEC	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.25
p.M700I	TCGA-B7-5816	STAD	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.25
p.D1203N	TCGA-BF-AAOX	SKCM	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation altering degron motif	0.6932
p.D1203N	SIDM00537	Colorectal Carcinoma	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation altering degron motif	0.6932
p.D1203N	ACH-000982	Colon/Colorectal Cancer	CCLE	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation altering degron motif	0.6932
p.D1203N	ACH-001345	Colon/Colorectal Cancer	CCLE	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation altering degron motif	0.6932
p.D1203N	GP5d	large intestine	COSMIC	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation altering degron motif	0.6932
p.V1113M	TCGA-BH-A18M	BRCA	TCGA	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation altering degron motif	0.6097
p.V1113M	TCGA-KB-A93H	STAD	TCGA	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation altering degron motif	0.6097
p.R1125C	TCGA-BM-6198	READ	TCGA	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.0556
p.G1205D	TCGA-CG-5723	STAD	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation altering degron motif	0.7198
p.S1204N	TCGA-CR-7399	HNSC	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation altering degron motif	0.7069
p.G1112V	TCGA-CV-6935	HNSC	TCGA	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation altering degron motif	0.7532
p.E1123K	TCGA-D3-A2JE	SKCM	TCGA	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.1111
p.H708Q	TCGA-DD-AACP	LIHC	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation altering degron motif	0.647
p.L1537I	TCGA-DF-A2KN	UCEC	TCGA	VKSSS	DEG_SPOP_SBC_1	1532:1536	Mutation rewiring degron network	0.3056
p.P1638Q	TCGA-EK-A3GJ	CESC	TCGA	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.0556
p.S1493I	TCGA-EL-A3MZ	THCA	TCGA	SSSSGE	DEG_Kelch_Keap1_1	1491:1496	Mutation altering degron motif	0.7341
p.L712I	TCGA-EY-A1GI	UCEC	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.3056
p.P1538L	TCGA-EY-A215	UCEC	TCGA	VKSSS	DEG_SPOP_SBC_1	1532:1536	Mutation rewiring degron network	0.2778
p.R706H	TCGA-FI-A2D5	UCEC	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation altering degron motif	0.7133
p.D1216N	TCGA-G4-6320	COAD	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.1389
p.P1486Q	TCGA-IB-7651	PAAD	TCGA	SSSSGE	DEG_Kelch_Keap1_1	1491:1496	Mutation rewiring degron network	0.1944
p.A411S	TCGA-L9-A444	LUAD	TCGA	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2778
p.A411G	TCGA-L9-A444	LUAD	TCGA	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2778
p.P1484L	TCGA-LN-A8I1	ESCA	TCGA	SSSSGE	DEG_Kelch_Keap1_1	1491:1496	Mutation rewiring degron network	0.1389
p.E1117K	TCGA-MI-A75E	LIHC	TCGA	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.2778
p.H1527Q	TCGA-NC-A5HP	LUSC	TCGA	VKSSS	DEG_SPOP_SBC_1	1532:1536	Mutation rewiring degron network	0.1944
p.C715S	TCGA-NJ-A4YQ	LUAD	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.2222
p.P1026Q	TCGA-OR-A5KB	ACC	TCGA	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation altering degron motif	0.7035
p.S1545N	TCGA-SJ-A6ZI	UCEC	TCGA	VKSSS	DEG_SPOP_SBC_1	1532:1536	Mutation rewiring degron network	0.0833
p.A1034T	TCGA-T9-A92H	COAD	TCGA	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.2222
p.R1206C	TCGA-Z6-A8JE	ESCA	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation altering degron motif	0.719
p.K697N	TCGA-ZF-A9RC	BLCA	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation substituting flanking lysine	0.2778
p.A1017S	DO51935	BLCA	ICGC	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.0833
p.E1655K	DO223590	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.25
p.E1655K	DO8842	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.25
p.S1538R	DO219093	BLCA	ICGC	VKSSS	DEG_SPOP_SBC_1	1532:1536	Mutation rewiring degron network	0.2778
p.S1532L	DO224768	BRCA	ICGC	VKSSS	DEG_SPOP_SBC_1	1532:1536	Mutation altering degron motif	0.7667
p.P1026L	DO228426	BRCA	ICGC	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation altering degron motif	0.7582
p.I1639V	DO1285	BRCA	ICGC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.0833
p.R1643H	DO3110	BRCA	ICGC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.1944
p.R1643H	DO12478	GBM	ICGC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.1944
p.R1643H	DO219795	LGG	ICGC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.1944
p.R1643H	DO50180	LGG	ICGC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.1944
p.R1643H	DO30740	OV	ICGC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.1944
p.R1643H	DO219339	PRAD	ICGC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.1944
p.R1643H	YKG-1	central nervous system	COSMIC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.1944
p.R1643H	SNU-1040	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.1944
p.R1210G	DO219589	BRCA	ICGC	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.3056
p.R416K	DO44362	CESC	ICGC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.1389
p.R1021W	DO10742	COAD	ICGC	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.1944
p.A395V	DO10132	COAD	ICGC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.0556
p.E1539K	DO7878	COAD	ICGC	VKSSS	DEG_SPOP_SBC_1	1532:1536	Mutation rewiring degron network	0.25
p.E1641K	DO223703	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.1389
p.A400V	DO8634	COAD	ICGC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation substituting flanking lysine	0.3056
p.R1522W	DO227990	COCA	ICGC	VKSSS	DEG_SPOP_SBC_1	1532:1536	Mutation rewiring degron network	0.0556
p.A721T	DO50388	ESAD	ICGC	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation substituting flanking lysine	0.1667
p.A1035P	DO50323	ESAD	ICGC	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.1944
p.A1648T	DO234183	ESAD	ICGC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation altering degron motif	0.7139
p.A1648T	DO27963	ORCA	ICGC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation altering degron motif	0.7139
p.A1648T	MDA-MB-415	breast	COSMIC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation altering degron motif	0.7139
p.C1482S	DO233855	GACA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	1491:1496	Mutation rewiring degron network	0.0833
p.A1031T	DO10880	GBM	ICGC	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.3056
p.A1031T	DO43907	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.3056
p.R1643C	DO49036	HNSC	ICGC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.1944
p.R1643C	DO22225	LGG	ICGC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.1944
p.Y404S	DO50651	KIRC	ICGC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.D1123V	DO51024	LAML	ICGC	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.1111
p.S415L	DO22237	LGG	ICGC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.1667
p.S415L	DO37831	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.1667
p.S1484R	DO50940	LICA	ICGC	SSSSGE	DEG_Kelch_Keap1_1	1491:1496	Mutation rewiring degron network	0.1389
p.A1652T	DO22835	LIHC	ICGC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation altering degron motif	0.7139
p.A1652T	OACM5-1	oesophagus	COSMIC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation altering degron motif	0.7139
p.P1033S	DO229177	LMS	ICGC	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.25
p.Q412K	DO45335	LUAD	ICGC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.25
p.L408M	DO25937	LUAD	ICGC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.711
p.R1210Q	DO230927	LUSC	ICGC	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.3056
p.R1210Q	DO224570	LUSC	ICGC	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.3056
p.G1198R	DO45482	LUSC	ICGC	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.1944
p.G1114A	DO45540	LUSC	ICGC	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation altering degron motif	0.754
p.H1642Q	DO27620	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.1667
p.Y698H	DO228355	MALY	ICGC	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.1944
p.S1543F	DO220876	MELA	ICGC	VKSSS	DEG_SPOP_SBC_1	1532:1536	Mutation substituting flanking lysine	0.25
p.S1543F	DO222363	MELA	ICGC	VKSSS	DEG_SPOP_SBC_1	1532:1536	Mutation substituting flanking lysine	0.25
p.S1543F	DO37839	SKCM	ICGC	VKSSS	DEG_SPOP_SBC_1	1532:1536	Mutation substituting flanking lysine	0.25
p.P1105Q	DO46657	PAAD	ICGC	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.1944
p.T1505M	DO50417	PRAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	1491:1496	Mutation rewiring degron network	0.0833
p.S702R	DO36556	READ	ICGC	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.3056
p.R1021Q	DO37042	READ	ICGC	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.1944
p.S1202F	DO229446	SKCA	ICGC	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.3056
p.R1646K	DO47485	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.2778
p.V1544M	DO38443	STAD	ICGC	VKSSS	DEG_SPOP_SBC_1	1532:1536	Mutation rewiring degron network	0.1111
p.K709E	DO38404	STAD	ICGC	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation altering degron motif	0.7022
p.D1489G	DO38404	STAD	ICGC	SSSSGE	DEG_Kelch_Keap1_1	1491:1496	Mutation rewiring degron network	0.2778
p.E1525D	DO229272	THCA	ICGC	VKSSS	DEG_SPOP_SBC_1	1532:1536	Mutation rewiring degron network	0.1389
p.G1528S	DO229087	THCA	ICGC	VKSSS	DEG_SPOP_SBC_1	1532:1536	Mutation rewiring degron network	0.2222
p.S1112I	DO39505	THCA	ICGC	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation altering degron motif	0.7341
p.H396Y	DO219774	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.0833
p.Q706R	DO42033	UCEC	ICGC	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation altering degron motif	0.7329
p.R1651H	DO43634	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation altering degron motif	0.8244
p.K1193N	DO223286	UCEC	ICGC	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.0556
p.S409P	DO43186	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.6752
p.A405T	DO43186	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.7139
p.A405V	DO41638	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.6936
p.S696L	DO41488	UCEC	ICGC	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.1389
p.K1638N	DO41331	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.0556
p.K1638N	HCC2998	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.0556
p.R706C	SIDM02039	Colorectal Carcinoma	GDSC	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation altering degron motif	0.719
p.R404Q	SIDM01023	Acute Myeloid Leukemia	GDSC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.R404Q	MONO-MAC-6	haematopoietic and lymphoid tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.S1040N	SIDM00967	Ovarian Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.0556
p.S1218F	SIDM00705	Non-Cancerous	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.0833
p.S1218F	SIDM00657	Acute Myeloid Leukemia	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.0833
p.S1218F	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.0833
p.S1218F	SIDM00706	Small Cell Lung Carcinoma	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.0833
p.Q1121H	SIDM00535	Chondrosarcoma	GDSC	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.1667
p.Q1121H	ACH-001519	Bone Cancer	CCLE	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.1667
p.Q1121H	H-EMC-SS	bone	COSMIC	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.1667
p.S1651N	SIDM00120	Prostate Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation altering degron motif	0.7069
p.S1651N	ACH-000979	Prostate Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation altering degron motif	0.7069
p.V1038M	SIDM00846	Cervical Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.1111
p.L1490F	SIDM01259	B-Lymphoblastic Leukemia	GDSC	SSSSGE	DEG_Kelch_Keap1_1	1491:1496	Mutation rewiring degron network	0.3056
p.L1490F	ACH-002238	Leukemia	CCLE	SSSSGE	DEG_Kelch_Keap1_1	1491:1496	Mutation rewiring degron network	0.3056
p.L1490F	GR-ST	haematopoietic and lymphoid tissue	COSMIC	SSSSGE	DEG_Kelch_Keap1_1	1491:1496	Mutation rewiring degron network	0.3056
p.R1206H	SIDM00660	Colorectal Carcinoma	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation altering degron motif	0.7133
p.R1206H	ACH-000985	Colon/Colorectal Cancer	CCLE	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation altering degron motif	0.7133
p.R1206H	LS-411N	large intestine	COSMIC	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation altering degron motif	0.7133
p.L1120M	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.1944
p.L1120M	ACH-000893	Lung Cancer	CCLE	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.1944
p.L1120M	NCI-H1651	lung	COSMIC	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.1944
p.S1024N	SIDM01145	Gastric Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.2778
p.S1024N	ACH-000581	Gastric Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.2778
p.S1016T	SIDM01161	Other Sarcomas	GDSC	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation blocking phosphorylation signal	0.5
p.S1016T	ACH-001274	Sarcoma	CCLE	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation blocking phosphorylation signal	0.5
p.S1016T	SW982	soft tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation blocking phosphorylation signal	0.5
p.R1546W	SIDM00346	Chronic Myelogenous Leukemia	GDSC	VKSSS	DEG_SPOP_SBC_1	1532:1536	Mutation rewiring degron network	0.0556
p.R1546W	SIDM01043	Other Sarcomas	GDSC	VKSSS	DEG_SPOP_SBC_1	1532:1536	Mutation rewiring degron network	0.0556
p.S1498L	SIDM00963	Breast Carcinoma	GDSC	SSSSGE	DEG_Kelch_Keap1_1	1491:1496	Mutation rewiring degron network	0.2778
p.S1498L	ACH-000927	Breast Cancer	CCLE	SSSSGE	DEG_Kelch_Keap1_1	1491:1496	Mutation rewiring degron network	0.2778
p.S1498L	BT-474	breast	COSMIC	SSSSGE	DEG_Kelch_Keap1_1	1491:1496	Mutation rewiring degron network	0.2778
p.P1484H	SIDM00841	Colorectal Carcinoma	GDSC	SSSSGE	DEG_Kelch_Keap1_1	1491:1496	Mutation rewiring degron network	0.1389
p.P1484H	ACH-000651	Colon/Colorectal Cancer	CCLE	SSSSGE	DEG_Kelch_Keap1_1	1491:1496	Mutation rewiring degron network	0.1389
p.P1484H	SW620	large intestine	COSMIC	SSSSGE	DEG_Kelch_Keap1_1	1491:1496	Mutation rewiring degron network	0.1389
p.A410T	SIDM00833	Colorectal Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.A410T	SW837	large intestine	COSMIC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.S1199I	SIDM00670	Pancreatic Carcinoma	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.2222
p.S1199I	ACH-000270	Pancreatic Cancer	CCLE	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.2222
p.S1199I	ACH-001098	Pancreatic Cancer	CCLE	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.2222
p.S1199I	HPAC	pancreas	COSMIC	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.2222
p.E1640K	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation rewiring degron network	0.1111
p.P1106S	SIDM00006	Other Solid Cancers	GDSC	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.2222
p.P1106S	ACH-001552	Skin Cancer	CCLE	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.2222
p.P1106S	MCC26	skin	COSMIC	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.2222
p.A1102T	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.1111
p.S1536N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VKSSS	DEG_SPOP_SBC_1	1532:1536	Mutation altering degron motif	0.7069
p.S1536N	ACH-002222	Leukemia	CCLE	VKSSS	DEG_SPOP_SBC_1	1532:1536	Mutation altering degron motif	0.7069
p.S1536N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	VKSSS	DEG_SPOP_SBC_1	1532:1536	Mutation altering degron motif	0.7069
p.A1034V	SIDM01018	Hodgkin's Lymphoma	GDSC	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.2222
p.A1034V	ACH-000815	Lymphoma	CCLE	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.2222
p.A1034V	KM-H2	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.2222
p.L1196P	SIDM00901	Endometrial Carcinoma	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.1389
p.L1196P	ACH-000940	Endometrial/Uterine Cancer	CCLE	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.1389
p.L1196P	AN3-CA	endometrium	COSMIC	DSGRPTS	DEG_SCF_TRCP1_1	1203:1209	Mutation rewiring degron network	0.1389
p.E412K	SIDM01709	Melanoma	GDSC	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.25
p.E412K	ACH-000275	Non-Cancerous	CCLE	PSTSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.25
p.A1102S	SIDM01574	Plasma Cell Myeloma	GDSC	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.1111
p.A1102S	ACH-000588	Myeloma	CCLE	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.1111
p.G703C	ACH-000552	Colon/Colorectal Cancer	CCLE	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation altering degron motif	0.6489
p.G702A	ACH-000649	Kidney Cancer	CCLE	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.3056
p.V1025I	ACH-001484	Leukemia	CCLE	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.3056
p.V1025I	ACH-001485	Leukemia	CCLE	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.3056
p.S1040R	ACH-001568	Skin Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.0556
p.A1652V	HCC70	breast	COSMIC	ASSSS	DEG_SPOP_SBC_1	1648:1652	Mutation altering degron motif	0.6936
p.G1036S	HCT-116	large intestine	COSMIC	PGSSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.1667
p.S1117L	BT-474	breast	COSMIC	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.2778
p.S703F	OMC-1	cervix	COSMIC	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation altering degron motif	0.7982
p.V710A	HCC1569	breast	COSMIC	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation altering degron motif	0.6936
p.Y711H	SNU-C1	large intestine	COSMIC	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation altering degron motif	0.7229
p.P1103H	SW620	large intestine	COSMIC	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.1389
p.K714N	HCC2998	large intestine	COSMIC	GRSRLHLID	DEG_APCC_DBOX_1	703:711	Mutation rewiring degron network	0.25
p.L1109F	GR-ST	haematopoietic and lymphoid tissue	COSMIC	DSGVAS	DEG_SCF_TRCP1_1	1110:1115	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF26B

UniProt ID: Q2KJY2

Entrez ID: 55083

Protein name: Kinesin-like protein KIF26B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF26B in