DegronMD

Uniprot ID: Q2KJY2

Source protein: Kinesin-like protein KIF26B

Source gene: KIF26B

Class: DEG_APCC_DBOX_1

Location: 703:711

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5339

ASA_SCORE: 39.5889

COIL: 0.3024

CONS_SCORE: 0.8862

DSS_SCORE: 0.258

HELIX: 0.036

FCONS_SCORE: 1.6044

RIG_SCORE: 0.7807

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G713C	TCGA-09-2044	OV	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	0.2778
p.G713C	TCGA-ER-A19T	SKCM	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	0.2778
p.R704H	TCGA-2Y-A9H6	LIHC	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	0.8244
p.R704H	TCGA-AA-3655	COAD	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	0.8244
p.G696V	TCGA-43-2581	LUSC	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	0.1389
p.G696W	TCGA-94-8490	LUSC	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	0.1389
p.M700I	TCGA-B7-5816	STAD	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	0.25
p.H708Q	TCGA-DD-AACP	LIHC	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	0.647
p.L712I	TCGA-EY-A1GI	UCEC	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	0.3056
p.R706H	TCGA-FI-A2D5	UCEC	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	0.7133
p.C715S	TCGA-NJ-A4YQ	LUAD	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	0.2222
p.K697N	TCGA-ZF-A9RC	BLCA	TCGA	GRSRLHLID	DEG_APCC_DBOX_1	0.2778
p.A721T	DO50388	ESAD	ICGC	GRSRLHLID	DEG_APCC_DBOX_1	0.1667
p.Y698H	DO228355	MALY	ICGC	GRSRLHLID	DEG_APCC_DBOX_1	0.1944
p.S702R	DO36556	READ	ICGC	GRSRLHLID	DEG_APCC_DBOX_1	0.3056
p.K709E	DO38404	STAD	ICGC	GRSRLHLID	DEG_APCC_DBOX_1	0.7022
p.Q706R	DO42033	UCEC	ICGC	GRSRLHLID	DEG_APCC_DBOX_1	0.7329
p.S696L	DO41488	UCEC	ICGC	GRSRLHLID	DEG_APCC_DBOX_1	0.1389
p.R706C	SIDM02039	Colorectal Carcinoma	GDSC	GRSRLHLID	DEG_APCC_DBOX_1	0.719
p.G703C	ACH-000552	Colon/Colorectal Cancer	CCLE	GRSRLHLID	DEG_APCC_DBOX_1	0.6489
p.G702A	ACH-000649	Kidney Cancer	CCLE	GRSRLHLID	DEG_APCC_DBOX_1	0.3056
p.S703F	OMC-1	cervix	COSMIC	GRSRLHLID	DEG_APCC_DBOX_1	0.7982
p.V710A	HCC1569	breast	COSMIC	GRSRLHLID	DEG_APCC_DBOX_1	0.6936
p.Y711H	SNU-C1	large_intestine	COSMIC	GRSRLHLID	DEG_APCC_DBOX_1	0.7229
p.K714N	HCC2998	large_intestine	COSMIC	GRSRLHLID	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2KJY2	Kinesin-like protein KIF26B	DEG_APCC_DBOX_1	703:711	GRSRLHLID	APC,CDC20,FZR1	0.5339	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRSRLHLID

Degron related mutations and impact score

Drug responses associated with KIF26B mutations

All proteins holding degron of GRSRLHLID