DegronMD

Uniprot ID: Q2KJY2

Source protein: Kinesin-like protein KIF26B

Source gene: KIF26B

Class: DEG_SCF_TRCP1_1

Location: 1203:1209

E3 ligase: BTRC

DEGRON score: 0.6251

ASA_SCORE: 71.8571

COIL: 0.8196

CONS_SCORE: 0.3854

DSS_SCORE: 0.2038

HELIX: 0.0633

FCONS_SCORE: 0.9883

RIG_SCORE: 0.7496

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1205D	TCGA-CG-5723	STAD	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	0.7198
p.R1206C	TCGA-Z6-A8JE	ESCA	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	0.719
p.R1206H	SIDM00660	Colorectal Carcinoma	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	0.7133
p.R1206H	ACH-000985	Colon/Colorectal Cancer	CCLE	DSGRPTS	DEG_SCF_TRCP1_1	0.7133
p.R1206H	LS-411N	large_intestine	COSMIC	DSGRPTS	DEG_SCF_TRCP1_1	0.7133
p.S1204N	TCGA-CR-7399	HNSC	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	0.7069
p.D1203N	TCGA-BF-AAOX	SKCM	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	0.6932
p.D1203N	SIDM00537	Colorectal Carcinoma	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	0.6932
p.D1203N	ACH-000982	Colon/Colorectal Cancer	CCLE	DSGRPTS	DEG_SCF_TRCP1_1	0.6932
p.D1203N	ACH-001345	Colon/Colorectal Cancer	CCLE	DSGRPTS	DEG_SCF_TRCP1_1	0.6932
p.D1203N	GP5d	large_intestine	COSMIC	DSGRPTS	DEG_SCF_TRCP1_1	0.6932
p.L1202P	TCGA-AP-A1DK	UCEC	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	0.3056
p.R1210G	DO219589	BRCA	ICGC	DSGRPTS	DEG_SCF_TRCP1_1	0.3056
p.R1210Q	DO230927	LUSC	ICGC	DSGRPTS	DEG_SCF_TRCP1_1	0.3056
p.R1210Q	DO224570	LUSC	ICGC	DSGRPTS	DEG_SCF_TRCP1_1	0.3056
p.S1202F	DO229446	SKCA	ICGC	DSGRPTS	DEG_SCF_TRCP1_1	0.3056
p.S1212N	TCGA-AX-A2HC	UCEC	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	0.25
p.S1199I	SIDM00670	Pancreatic Carcinoma	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	0.2222
p.S1199I	ACH-000270	Pancreatic Cancer	CCLE	DSGRPTS	DEG_SCF_TRCP1_1	0.2222
p.S1199I	ACH-001098	Pancreatic Cancer	CCLE	DSGRPTS	DEG_SCF_TRCP1_1	0.2222
p.S1199I	HPAC	pancreas	COSMIC	DSGRPTS	DEG_SCF_TRCP1_1	0.2222
p.G1198R	DO45482	LUSC	ICGC	DSGRPTS	DEG_SCF_TRCP1_1	0.1944
p.D1216N	TCGA-G4-6320	COAD	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	0.1389
p.L1196P	SIDM00901	Endometrial Carcinoma	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	0.1389
p.L1196P	ACH-000940	Endometrial/Uterine Cancer	CCLE	DSGRPTS	DEG_SCF_TRCP1_1	0.1389

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Drug responses associated with KIF26B mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of DSGRPTS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2KJY2	Kinesin-like protein KIF26B	DEG_SCF_TRCP1_1	1203:1209	DSGRPTS	BTRC	0.6251	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGRPTS

Degron related mutations and impact score

Drug responses associated with KIF26B mutations

All proteins holding degron of DSGRPTS