DegronMD

Uniprot ID: Q2KJY2

Source protein: Kinesin-like protein KIF26B

Source gene: KIF26B

Class: DEG_SCF_TRCP1_1

Location: 1203:1209

E3 ligase: BTRC

DEGRON score: 0.6251

ASA_SCORE: 71.8571

COIL: 0.8196

CONS_SCORE: 0.3854

DSS_SCORE: 0.2038

HELIX: 0.0633

FCONS_SCORE: 0.9883

RIG_SCORE: 0.7496

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1202P	TCGA-AP-A1DK	UCEC	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	0.3056
p.S1212N	TCGA-AX-A2HC	UCEC	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	0.25
p.D1203N	TCGA-BF-AAOX	SKCM	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	0.6932
p.D1203N	SIDM00537	Colorectal Carcinoma	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	0.6932
p.D1203N	ACH-000982	Colon/Colorectal Cancer	CCLE	DSGRPTS	DEG_SCF_TRCP1_1	0.6932
p.D1203N	ACH-001345	Colon/Colorectal Cancer	CCLE	DSGRPTS	DEG_SCF_TRCP1_1	0.6932
p.D1203N	GP5d	large_intestine	COSMIC	DSGRPTS	DEG_SCF_TRCP1_1	0.6932
p.G1205D	TCGA-CG-5723	STAD	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	0.7198
p.S1204N	TCGA-CR-7399	HNSC	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	0.7069
p.D1216N	TCGA-G4-6320	COAD	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	0.1389
p.R1206C	TCGA-Z6-A8JE	ESCA	TCGA	DSGRPTS	DEG_SCF_TRCP1_1	0.719
p.R1210G	DO219589	BRCA	ICGC	DSGRPTS	DEG_SCF_TRCP1_1	0.3056
p.R1210Q	DO230927	LUSC	ICGC	DSGRPTS	DEG_SCF_TRCP1_1	0.3056
p.R1210Q	DO224570	LUSC	ICGC	DSGRPTS	DEG_SCF_TRCP1_1	0.3056
p.G1198R	DO45482	LUSC	ICGC	DSGRPTS	DEG_SCF_TRCP1_1	0.1944
p.S1202F	DO229446	SKCA	ICGC	DSGRPTS	DEG_SCF_TRCP1_1	0.3056
p.K1193N	DO223286	UCEC	ICGC	DSGRPTS	DEG_SCF_TRCP1_1	0.0556
p.S1218F	SIDM00705	Non-Cancerous	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	0.0833
p.S1218F	SIDM00657	Acute Myeloid Leukemia	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	0.0833
p.S1218F	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	0.0833
p.S1218F	SIDM00706	Small Cell Lung Carcinoma	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	0.0833
p.R1206H	SIDM00660	Colorectal Carcinoma	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	0.7133
p.R1206H	ACH-000985	Colon/Colorectal Cancer	CCLE	DSGRPTS	DEG_SCF_TRCP1_1	0.7133
p.R1206H	LS-411N	large_intestine	COSMIC	DSGRPTS	DEG_SCF_TRCP1_1	0.7133
p.S1199I	SIDM00670	Pancreatic Carcinoma	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	0.2222
p.S1199I	ACH-000270	Pancreatic Cancer	CCLE	DSGRPTS	DEG_SCF_TRCP1_1	0.2222
p.S1199I	ACH-001098	Pancreatic Cancer	CCLE	DSGRPTS	DEG_SCF_TRCP1_1	0.2222
p.S1199I	HPAC	pancreas	COSMIC	DSGRPTS	DEG_SCF_TRCP1_1	0.2222
p.L1196P	SIDM00901	Endometrial Carcinoma	GDSC	DSGRPTS	DEG_SCF_TRCP1_1	0.1389
p.L1196P	ACH-000940	Endometrial/Uterine Cancer	CCLE	DSGRPTS	DEG_SCF_TRCP1_1	0.1389
p.L1196P	AN3-CA	endometrium	COSMIC	DSGRPTS	DEG_SCF_TRCP1_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGRPTS

Degron related mutations and impact score

Drug responses associated with KIF26B mutations

All proteins holding degron of DSGRPTS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2KJY2	Kinesin-like protein KIF26B	DEG_SCF_TRCP1_1	1203:1209	DSGRPTS	BTRC	0.6251	More...