DegronMD

Uniprot ID: Q2KJY2

Source protein: Kinesin-like protein KIF26B

Source gene: KIF26B

Class: DEG_SPOP_SBC_1

Location: 1532:1536

E3 ligase: SPOP

DEGRON score: 0.9092

ASA_SCORE: 82.16

COIL: 0.8262

CONS_SCORE: 0.3848

DSS_SCORE: 0.5575

HELIX: 0.1206

FCONS_SCORE: 1.17

RIG_SCORE: 0.6536

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1537I	TCGA-DF-A2KN	UCEC	TCGA	VKSSS	DEG_SPOP_SBC_1	0.3056
p.P1538L	TCGA-EY-A215	UCEC	TCGA	VKSSS	DEG_SPOP_SBC_1	0.2778
p.H1527Q	TCGA-NC-A5HP	LUSC	TCGA	VKSSS	DEG_SPOP_SBC_1	0.1944
p.S1545N	TCGA-SJ-A6ZI	UCEC	TCGA	VKSSS	DEG_SPOP_SBC_1	0.0833
p.S1538R	DO219093	BLCA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.2778
p.S1532L	DO224768	BRCA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.7667
p.E1539K	DO7878	COAD	ICGC	VKSSS	DEG_SPOP_SBC_1	0.25
p.R1522W	DO227990	COCA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.0556
p.S1543F	DO220876	MELA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.25
p.S1543F	DO222363	MELA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.25
p.S1543F	DO37839	SKCM	ICGC	VKSSS	DEG_SPOP_SBC_1	0.25
p.V1544M	DO38443	STAD	ICGC	VKSSS	DEG_SPOP_SBC_1	0.1111
p.E1525D	DO229272	THCA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.1389
p.G1528S	DO229087	THCA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.2222
p.R1546W	SIDM00346	Chronic Myelogenous Leukemia	GDSC	VKSSS	DEG_SPOP_SBC_1	0.0556
p.R1546W	SIDM01043	Other Sarcomas	GDSC	VKSSS	DEG_SPOP_SBC_1	0.0556
p.S1536N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VKSSS	DEG_SPOP_SBC_1	0.7069
p.S1536N	ACH-002222	Leukemia	CCLE	VKSSS	DEG_SPOP_SBC_1	0.7069
p.S1536N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	VKSSS	DEG_SPOP_SBC_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60882	Matrix metalloproteinase-20	DEG_SPOP_SBC_1	475:479	VKSSS	SPOP	0.6246	More...
O75952	Calcium-binding tyrosine phosphorylation-regulated protein	DEG_SPOP_SBC_1	465:469	VKSSS	SPOP	0.975	More...
P29375	Lysine-specific demethylase 5A	DEG_SPOP_SBC_1	1363:1367	VKSSS	SPOP	0.9347	More...
P55197	Protein AF-10	DEG_SPOP_SBC_1	360:364	VKSSS	SPOP	0.8251	More...
Q2LD37	Transmembrane protein KIAA1109	DEG_SPOP_SBC_1	2319:2323	VKSSS	SPOP	0.9728	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	3936:3940	VKSSS	SPOP	0.9325	More...
Q5U651	Ras-interacting protein 1	DEG_SPOP_SBC_1	45:49	VKSSS	SPOP	0.9869	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	686:690	VKSSS	SPOP	0.9003	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	1269:1273	VKSSS	SPOP	0.9831	More...
Q9UMS6	Synaptopodin-2	DEG_SPOP_SBC_1	765:769	VKSSS	SPOP	0.9977	More...
Q2KJY2	Kinesin-like protein KIF26B	DEG_SPOP_SBC_1	1532:1536	VKSSS	SPOP	0.9092	More...
Q5JRM2	Uncharacterized protein CXorf66	DEG_SPOP_SBC_1	303:307	VKSSS	SPOP	0.9382	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons