DegronMD - Q5JRM2(CXorf66)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S132F	TCGA-23-1113	OV	TCGA	AQSST	DEG_SPOP_SBC_1	130:134	Mutation altering degron motif	0.7982
p.S132F	DO32093	OV	ICGC	AQSST	DEG_SPOP_SBC_1	130:134	Mutation altering degron motif	0.7982
p.I138V	TCGA-37-A5EL	LUSC	TCGA	AQSST	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.2222
p.I138V	DO223718	LUSC	ICGC	AQSST	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.2222
p.K304N	TCGA-46-3768	LUSC	TCGA	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation altering degron motif	0.5806
p.K304N	DO26466	LUSC	ICGC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation altering degron motif	0.5806
p.T294S	TCGA-66-2727	LUSC	TCGA	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.0833
p.T294S	DO26478	LUSC	ICGC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.0833
p.S309F	TCGA-AB-2833	LAML	TCGA	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.2778
p.S309F	TCGA-BF-AAP2	SKCM	TCGA	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.2778
p.S309F	DO21679	LAML	ICGC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.2778
p.S309F	DO219466	SKCM	ICGC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.2778
p.S122A	TCGA-AG-A002	READ	TCGA	AQSST	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.1111
p.A130T	TCGA-B5-A3FC	UCEC	TCGA	AQSST	DEG_SPOP_SBC_1	130:134	Mutation altering degron motif	0.7139
p.A130T	TCGA-D9-A1X3	SKCM	TCGA	AQSST	DEG_SPOP_SBC_1	130:134	Mutation altering degron motif	0.7139
p.A130T	DO37456	SKCM	ICGC	AQSST	DEG_SPOP_SBC_1	130:134	Mutation altering degron motif	0.7139
p.A130T	DO41871	UCEC	ICGC	AQSST	DEG_SPOP_SBC_1	130:134	Mutation altering degron motif	0.7139
p.L137I	TCGA-D1-A1NU	UCEC	TCGA	AQSST	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.25
p.L137I	DO43811	UCEC	ICGC	AQSST	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.25
p.S309Y	TCGA-D6-8569	HNSC	TCGA	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.2778
p.S309Y	DO14454	HNSC	ICGC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.2778
p.R311C	TCGA-EB-A41B	SKCM	TCGA	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.2222
p.R311C	TCGA-GN-A266	SKCM	TCGA	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.2222
p.R311C	TCGA-Z2-A8RT	SKCM	TCGA	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.2222
p.R311C	DO233777	GACA	ICGC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.2222
p.R311C	DO229465	SKCA	ICGC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.2222
p.R311C	DO37611	SKCM	ICGC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.2222
p.R311C	DO37432	SKCM	ICGC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.2222
p.R311C	DO51301	SKCM	ICGC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.2222
p.Q295K	TCGA-HD-8635	HNSC	TCGA	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.1111
p.Q295K	DO14574	HNSC	ICGC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.1111
p.D314V	DO217931	BRCA	ICGC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.1389
p.R311H	DO230331	COCA	ICGC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.2222
p.K312N	DO48212	ESCA	ICGC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation substituting flanking lysine	0.3056
p.S301C	DO233871	GACA	ICGC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.2778
p.A128E	DO229024	LICA	ICGC	AQSST	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.2778
p.P140T	DO229026	LICA	ICGC	AQSST	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.1667
p.V299D	DO231127	LUSC	ICGC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.2222
p.S307F	DO220873	MELA	ICGC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation altering degron motif	0.7982
p.S307F	SIDM00663	Melanoma	GDSC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation altering degron motif	0.7982
p.S307F	ACH-000814	Skin Cancer	CCLE	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation altering degron motif	0.7982
p.N296T	SIDM02059	Colorectal Carcinoma	GDSC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.1389
p.K302R	SIDM00336	Melanoma	GDSC	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.3056
p.K302R	ACH-000881	Skin Cancer	CCLE	VKSSS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.3056
p.P125S	SIDM01220	Glioma	GDSC	AQSST	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.1944
p.P125S	ACH-000760	Brain Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.1944
p.P125S	ACH-002269	Brain Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.1944
p.S123L	ACH-001991	Primary	CCLE	AQSST	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CXorf66

UniProt ID: Q5JRM2

Entrez ID: 347487

Protein name: Uncharacterized protein CXorf66

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CXorf66 in