DegronMD

Uniprot ID: Q5JRM2

Source protein: Uncharacterized protein CXorf66

Source gene: CXorf66

Class: DEG_SPOP_SBC_1

Location: 303:307

E3 ligase: SPOP

DEGRON score: 0.9382

ASA_SCORE: 79.6

COIL: 0.8312

CONS_SCORE: 0.4611

DSS_SCORE: 0.4963

HELIX: 0.0722

FCONS_SCORE: 0.9875

RIG_SCORE: 0.662

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K304N	TCGA-46-3768	LUSC	TCGA	VKSSS	DEG_SPOP_SBC_1	0.5806
p.K304N	DO26466	LUSC	ICGC	VKSSS	DEG_SPOP_SBC_1	0.5806
p.T294S	TCGA-66-2727	LUSC	TCGA	VKSSS	DEG_SPOP_SBC_1	0.0833
p.T294S	DO26478	LUSC	ICGC	VKSSS	DEG_SPOP_SBC_1	0.0833
p.S309F	TCGA-AB-2833	LAML	TCGA	VKSSS	DEG_SPOP_SBC_1	0.2778
p.S309F	TCGA-BF-AAP2	SKCM	TCGA	VKSSS	DEG_SPOP_SBC_1	0.2778
p.S309F	DO21679	LAML	ICGC	VKSSS	DEG_SPOP_SBC_1	0.2778
p.S309F	DO219466	SKCM	ICGC	VKSSS	DEG_SPOP_SBC_1	0.2778
p.S309Y	TCGA-D6-8569	HNSC	TCGA	VKSSS	DEG_SPOP_SBC_1	0.2778
p.S309Y	DO14454	HNSC	ICGC	VKSSS	DEG_SPOP_SBC_1	0.2778
p.R311C	TCGA-EB-A41B	SKCM	TCGA	VKSSS	DEG_SPOP_SBC_1	0.2222
p.R311C	TCGA-GN-A266	SKCM	TCGA	VKSSS	DEG_SPOP_SBC_1	0.2222
p.R311C	TCGA-Z2-A8RT	SKCM	TCGA	VKSSS	DEG_SPOP_SBC_1	0.2222
p.R311C	DO233777	GACA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.2222
p.R311C	DO229465	SKCA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.2222
p.R311C	DO37611	SKCM	ICGC	VKSSS	DEG_SPOP_SBC_1	0.2222
p.R311C	DO37432	SKCM	ICGC	VKSSS	DEG_SPOP_SBC_1	0.2222
p.R311C	DO51301	SKCM	ICGC	VKSSS	DEG_SPOP_SBC_1	0.2222
p.Q295K	TCGA-HD-8635	HNSC	TCGA	VKSSS	DEG_SPOP_SBC_1	0.1111
p.Q295K	DO14574	HNSC	ICGC	VKSSS	DEG_SPOP_SBC_1	0.1111
p.D314V	DO217931	BRCA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.1389
p.R311H	DO230331	COCA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.2222
p.K312N	DO48212	ESCA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.3056
p.S301C	DO233871	GACA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.2778
p.V299D	DO231127	LUSC	ICGC	VKSSS	DEG_SPOP_SBC_1	0.2222
p.S307F	DO220873	MELA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.7982
p.S307F	SIDM00663	Melanoma	GDSC	VKSSS	DEG_SPOP_SBC_1	0.7982
p.S307F	ACH-000814	Skin Cancer	CCLE	VKSSS	DEG_SPOP_SBC_1	0.7982
p.N296T	SIDM02059	Colorectal Carcinoma	GDSC	VKSSS	DEG_SPOP_SBC_1	0.1389
p.K302R	SIDM00336	Melanoma	GDSC	VKSSS	DEG_SPOP_SBC_1	0.3056
p.K302R	ACH-000881	Skin Cancer	CCLE	VKSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60882	Matrix metalloproteinase-20	DEG_SPOP_SBC_1	475:479	VKSSS	SPOP	0.6246	More...
O75952	Calcium-binding tyrosine phosphorylation-regulated protein	DEG_SPOP_SBC_1	465:469	VKSSS	SPOP	0.975	More...
P29375	Lysine-specific demethylase 5A	DEG_SPOP_SBC_1	1363:1367	VKSSS	SPOP	0.9347	More...
P55197	Protein AF-10	DEG_SPOP_SBC_1	360:364	VKSSS	SPOP	0.8251	More...
Q2LD37	Transmembrane protein KIAA1109	DEG_SPOP_SBC_1	2319:2323	VKSSS	SPOP	0.9728	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	3936:3940	VKSSS	SPOP	0.9325	More...
Q5U651	Ras-interacting protein 1	DEG_SPOP_SBC_1	45:49	VKSSS	SPOP	0.9869	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	686:690	VKSSS	SPOP	0.9003	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	1269:1273	VKSSS	SPOP	0.9831	More...
Q9UMS6	Synaptopodin-2	DEG_SPOP_SBC_1	765:769	VKSSS	SPOP	0.9977	More...
Q2KJY2	Kinesin-like protein KIF26B	DEG_SPOP_SBC_1	1532:1536	VKSSS	SPOP	0.9092	More...
Q5JRM2	Uncharacterized protein CXorf66	DEG_SPOP_SBC_1	303:307	VKSSS	SPOP	0.9382	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VKSSS

Degron related mutations and impact score

Drug responses associated with CXorf66 mutations

All proteins holding degron of VKSSS