DegronMD - P55197(MLLT10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T260N	TCGA-22-5481	LUSC	TCGA	EPSPALVPSL	DEG_COP1_1	250:259	Mutation rewiring degron network	0.3056
p.T260N	DO27160	LUSC	ICGC	EPSPALVPSL	DEG_COP1_1	250:259	Mutation rewiring degron network	0.3056
p.S364C	TCGA-4Z-AA81	BLCA	TCGA	VKSSS	DEG_SPOP_SBC_1	360:364	Mutation altering degron motif	0.7541
p.S364C	DO51868	BLCA	ICGC	VKSSS	DEG_SPOP_SBC_1	360:364	Mutation altering degron motif	0.7541
p.S359I	TCGA-60-2713	LUSC	TCGA	VKSSS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.3056
p.S359I	DO26476	LUSC	ICGC	VKSSS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.3056
p.S592F	TCGA-85-6561	LUSC	TCGA	PVSSS	DEG_SPOP_SBC_1	590:594	Mutation altering degron motif	0.7982
p.S592F	DO26518	LUSC	ICGC	PVSSS	DEG_SPOP_SBC_1	590:594	Mutation altering degron motif	0.7982
p.E264G	TCGA-AP-A0LM	UCEC	TCGA	EPSPALVPSL	DEG_COP1_1	250:259	Mutation rewiring degron network	0.1944
p.E264G	DO43306	UCEC	ICGC	EPSPALVPSL	DEG_COP1_1	250:259	Mutation rewiring degron network	0.1944
p.S587F	TCGA-B0-5119	KIRC	TCGA	PVSSS	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.25
p.S587F	DO18721	KIRC	ICGC	PVSSS	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.25
p.M882I	TCGA-B5-A3FA	UCEC	TCGA	PVTST	DEG_SPOP_SBC_1	884:888	Mutation rewiring degron network	0.2778
p.M882I	DO52402	UCEC	ICGC	PVTST	DEG_SPOP_SBC_1	884:888	Mutation rewiring degron network	0.2778
p.Y267C	TCGA-CA-6717	COAD	TCGA	EPSPALVPSL	DEG_COP1_1	250:259	Mutation rewiring degron network	0.1111
p.Y267C	DO8264	COAD	ICGC	EPSPALVPSL	DEG_COP1_1	250:259	Mutation rewiring degron network	0.1111
p.A891V	TCGA-CA-6717	COAD	TCGA	PVTST	DEG_SPOP_SBC_1	884:888	Mutation rewiring degron network	0.25
p.A891V	DO8264	COAD	ICGC	PVTST	DEG_SPOP_SBC_1	884:888	Mutation rewiring degron network	0.25
p.G312A	TCGA-CN-4736	HNSC	TCGA	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0833
p.G312A	DO15118	HNSC	ICGC	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0833
p.Q295H	TCGA-EE-A181	SKCM	TCGA	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.2222
p.Q295H	DO37444	SKCM	ICGC	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.2222
p.K242T	TCGA-EO-A22X	UCEC	TCGA	EPSPALVPSL	DEG_COP1_1	250:259	Mutation substituting flanking lysine	0.2222
p.K242T	DO43907	UCEC	ICGC	EPSPALVPSL	DEG_COP1_1	250:259	Mutation substituting flanking lysine	0.2222
p.L255F	TCGA-ER-A1A1	SKCM	TCGA	EPSPALVPSL	DEG_COP1_1	250:259	Mutation altering degron motif	0.587
p.L255F	DO37413	SKCM	ICGC	EPSPALVPSL	DEG_COP1_1	250:259	Mutation altering degron motif	0.587
p.H595N	TCGA-FS-A1ZQ	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.3056
p.H595N	DO225215	BRCA	ICGC	PVSSS	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.3056
p.H595N	DO227836	BRCA	ICGC	PVSSS	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.3056
p.H595N	DO37442	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.3056
p.V591I	TCGA-HJ-7597	STAD	TCGA	PVSSS	DEG_SPOP_SBC_1	590:594	Mutation altering degron motif	0.5965
p.V591I	DO38195	STAD	ICGC	PVSSS	DEG_SPOP_SBC_1	590:594	Mutation altering degron motif	0.5965
p.S313L	TCGA-XK-AAIW	PRAD	TCGA	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation blocking phosphorylation signal	0.5
p.S313L	DO51407	PRAD	ICGC	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation blocking phosphorylation signal	0.5
p.S302C	DO218173	BRCA	ICGC	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7541
p.K361Q	DO7801	COAD	ICGC	VKSSS	DEG_SPOP_SBC_1	360:364	Mutation altering degron motif	0.5833
p.G365R	DO228189	LICA	ICGC	VKSSS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.3056
p.A254S	DO228978	LICA	ICGC	EPSPALVPSL	DEG_COP1_1	250:259	Mutation altering degron motif	0.6477
p.V256F	DO229028	LICA	ICGC	EPSPALVPSL	DEG_COP1_1	250:259	Mutation altering degron motif	0.7068
p.A879S	DO229025	LICA	ICGC	PVTST	DEG_SPOP_SBC_1	884:888	Mutation rewiring degron network	0.1944
p.A292P	DO229030	LICA	ICGC	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.G583C	DO229045	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.1389
p.S313T	DO229052	LICA	ICGC	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation blocking phosphorylation signal	0.5
p.P357L	DO220906	MELA	ICGC	VKSSS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.25
p.F374Y	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	VKSSS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.0556
p.F374Y	ACH-000914	Lymphoma	CCLE	VKSSS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.0556
p.F374Y	HT	haematopoietic and lymphoid tissue	COSMIC	VKSSS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.0556
p.T310A	SIDM00845	Burkitt's Lymphoma	GDSC	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.T310A	SIDM00035	Thyroid Gland Carcinoma	GDSC	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.T310A	SIDM00461	Acute Myeloid Leukemia	GDSC	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.T310A	SIDM01519	Head and Neck Carcinoma	GDSC	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.T310A	ACH-000037	Sarcoma	CCLE	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.T310A	ACH-000786	Lymphoma	CCLE	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.T310A	ACH-000992	Head and Neck Cancer	CCLE	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.T310A	ACH-001067	Brain Cancer	CCLE	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.T310A	Daudi	haematopoietic and lymphoid tissue	COSMIC	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.G602W	SIDM00614	Hepatocellular Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.1111
p.G602W	ACH-000848	Liver Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.1111
p.G602W	JHH-7	liver	COSMIC	PVSSS	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.1111
p.S352N	SIDM00190	Melanoma	GDSC	VKSSS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1111
p.S352N	ACH-002097	Skin Cancer	CCLE	VKSSS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1111
p.S352N	CP66-MEL	skin	COSMIC	VKSSS	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1111
p.A292T	SIDM01608	Endometrial Carcinoma	GDSC	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.A292T	ACH-000990	Endometrial/Uterine Cancer	CCLE	AHTSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.A874T	LS-411N	large intestine	COSMIC	PVTST	DEG_SPOP_SBC_1	884:888	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MLLT10

UniProt ID: P55197

Entrez ID: 8028

Protein name: Protein AF-10 (ALL1-fused gene from chromosome 10 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MLLT10 in