DegronMD

Uniprot ID: P55197

Source protein: Protein AF-10

Source gene: MLLT10

Class: DEG_SPOP_SBC_1

Location: 299:303

E3 ligase: SPOP

DEGRON score: 0.9984

ASA_SCORE: 78.5

COIL: 0.8552

CONS_SCORE: 0.3482

DSS_SCORE: 0.5851

HELIX: 0.0568

FCONS_SCORE: 1.0711

RIG_SCORE: 0.6567

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G312A	TCGA-CN-4736	HNSC	TCGA	AHTSS	DEG_SPOP_SBC_1	0.0833
p.G312A	DO15118	HNSC	ICGC	AHTSS	DEG_SPOP_SBC_1	0.0833
p.Q295H	TCGA-EE-A181	SKCM	TCGA	AHTSS	DEG_SPOP_SBC_1	0.2222
p.Q295H	DO37444	SKCM	ICGC	AHTSS	DEG_SPOP_SBC_1	0.2222
p.S313L	TCGA-XK-AAIW	PRAD	TCGA	AHTSS	DEG_SPOP_SBC_1	0.5
p.S313L	DO51407	PRAD	ICGC	AHTSS	DEG_SPOP_SBC_1	0.5
p.S302C	DO218173	BRCA	ICGC	AHTSS	DEG_SPOP_SBC_1	0.7541
p.A292P	DO229030	LICA	ICGC	AHTSS	DEG_SPOP_SBC_1	0.1389
p.S313T	DO229052	LICA	ICGC	AHTSS	DEG_SPOP_SBC_1	0.5
p.T310A	SIDM00845	Burkitt's Lymphoma	GDSC	AHTSS	DEG_SPOP_SBC_1	0.1389
p.T310A	SIDM00035	Thyroid Gland Carcinoma	GDSC	AHTSS	DEG_SPOP_SBC_1	0.1389
p.T310A	SIDM00461	Acute Myeloid Leukemia	GDSC	AHTSS	DEG_SPOP_SBC_1	0.1389
p.T310A	SIDM01519	Head and Neck Carcinoma	GDSC	AHTSS	DEG_SPOP_SBC_1	0.1389
p.T310A	ACH-000037	Sarcoma	CCLE	AHTSS	DEG_SPOP_SBC_1	0.1389
p.T310A	ACH-000786	Lymphoma	CCLE	AHTSS	DEG_SPOP_SBC_1	0.1389
p.T310A	ACH-000992	Head and Neck Cancer	CCLE	AHTSS	DEG_SPOP_SBC_1	0.1389
p.T310A	ACH-001067	Brain Cancer	CCLE	AHTSS	DEG_SPOP_SBC_1	0.1389
p.T310A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AHTSS	DEG_SPOP_SBC_1	0.1389
p.A292T	SIDM01608	Endometrial Carcinoma	GDSC	AHTSS	DEG_SPOP_SBC_1	0.1389
p.A292T	ACH-000990	Endometrial/Uterine Cancer	CCLE	AHTSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55197	Protein AF-10	DEG_SPOP_SBC_1	299:303	AHTSS	SPOP	0.9984	More...
Q5TH69	Brefeldin A-inhibited guanine nucleotide-exchange protein 3	DEG_SPOP_SBC_1	280:284	AHTSS	SPOP	0.532	More...
Q9C0C7	Activating molecule in BECN1-regulated autophagy protein 1	DEG_SPOP_SBC_1	1201:1205	AHTSS	SPOP	0.9814	More...
Q9Y6Y8	SEC23-interacting protein	DEG_SPOP_SBC_1	891:895	AHTSS	SPOP	0.9839	More...
Q8N9H9	Uncharacterized protein C1orf127	DEG_SPOP_SBC_1	583:587	AHTSS	SPOP	0.9833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons