DegronMD

Uniprot ID: Q9C0C7

Source protein: Activating molecule in BECN1-regulated autophagy protein 1

Source gene: AMBRA1

Class: DEG_SPOP_SBC_1

Location: 1201:1205

E3 ligase: SPOP

DEGRON score: 0.9814

ASA_SCORE: 82.62

COIL: 0.9098

CONS_SCORE: 0.3683

DSS_SCORE: 0.8311

HELIX: 0.025

FCONS_SCORE: 1.0127

RIG_SCORE: 0.5598

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1202M	ACH-002256	Leukemia	CCLE	AHTSS	DEG_SPOP_SBC_1	0.8632
p.R1202M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	AHTSS	DEG_SPOP_SBC_1	0.8632
p.R1202K	TCGA-AP-A05P	UCEC	TCGA	AHTSS	DEG_SPOP_SBC_1	0.7237
p.E1204G	SW1271	lung	COSMIC	AHTSS	DEG_SPOP_SBC_1	0.7199
p.S1202G	SIDM01307	Colorectal Carcinoma	GDSC	AHTSS	DEG_SPOP_SBC_1	0.6993
p.A1200S	NCI-H2342	lung	COSMIC	AHTSS	DEG_SPOP_SBC_1	0.3056
p.T1207A	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	AHTSS	DEG_SPOP_SBC_1	0.2778
p.T1207A	HT	haematopoietic_and_lymphoid_tissue	COSMIC	AHTSS	DEG_SPOP_SBC_1	0.2778
p.N1207Y	ACH-001118	Brain Cancer	CCLE	AHTSS	DEG_SPOP_SBC_1	0.2778
p.N1207Y	M059J	central_nervous_system	COSMIC	AHTSS	DEG_SPOP_SBC_1	0.2778
p.D1197G	TCGA-FA-A86F	DLBC	TCGA	AHTSS	DEG_SPOP_SBC_1	0.2222
p.P1195L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	AHTSS	DEG_SPOP_SBC_1	0.1667
p.S1194N	TCGA-B5-A11H	UCEC	TCGA	AHTSS	DEG_SPOP_SBC_1	0.1389
p.L1215F	SNU-C5	large_intestine	COSMIC	AHTSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0C7	Activating molecule in BECN1-regulated autophagy protein 1	DEG_SPOP_SBC_1	1201:1205	AHTSS	SPOP	0.9814	More...
Q5TH69	Brefeldin A-inhibited guanine nucleotide-exchange protein 3	DEG_SPOP_SBC_1	280:284	AHTSS	SPOP	0.532	More...
P55197	Protein AF-10	DEG_SPOP_SBC_1	299:303	AHTSS	SPOP	0.9984	More...
Q9Y6Y8	SEC23-interacting protein	DEG_SPOP_SBC_1	891:895	AHTSS	SPOP	0.9839	More...
Q8N9H9	Uncharacterized protein C1orf127	DEG_SPOP_SBC_1	583:587	AHTSS	SPOP	0.9833	More...

Showing 1 to 5 of 5 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons