DegronMD

Uniprot ID: Q5TH69

Source protein: Brefeldin A-inhibited guanine nucleotide-exchange protein 3

Source gene: ARFGEF3

Class: DEG_SPOP_SBC_1

Location: 280:284

E3 ligase: SPOP

DEGRON score: 0.532

ASA_SCORE: 79.32

COIL: 0.8434

CONS_SCORE: 0.3246

DSS_SCORE: 0.4944

HELIX: 0.0974

FCONS_SCORE: 0.9223

RIG_SCORE: 0.6763

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S291L	SIDM00860	Head and Neck Carcinoma	GDSC	AHTSS	DEG_SPOP_SBC_1	0.1389
p.S291L	FADU	upper_aerodigestive_tract	COSMIC	AHTSS	DEG_SPOP_SBC_1	0.1389
p.P271S	SIDM00719	Small Cell Lung Carcinoma	GDSC	AHTSS	DEG_SPOP_SBC_1	0.0833
p.P271S	NCI-H345	lung	COSMIC	AHTSS	DEG_SPOP_SBC_1	0.0833
p.D274E	SIDM00094	Kidney Carcinoma	GDSC	AHTSS	DEG_SPOP_SBC_1	0.1667
p.D274E	SN12C	kidney	COSMIC	AHTSS	DEG_SPOP_SBC_1	0.1667
p.T276S	SIDM00168	Head and Neck Carcinoma	GDSC	AHTSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55197	Protein AF-10	DEG_SPOP_SBC_1	299:303	AHTSS	SPOP	0.9984	More...
Q5TH69	Brefeldin A-inhibited guanine nucleotide-exchange protein 3	DEG_SPOP_SBC_1	280:284	AHTSS	SPOP	0.532	More...
Q9C0C7	Activating molecule in BECN1-regulated autophagy protein 1	DEG_SPOP_SBC_1	1201:1205	AHTSS	SPOP	0.9814	More...
Q9Y6Y8	SEC23-interacting protein	DEG_SPOP_SBC_1	891:895	AHTSS	SPOP	0.9839	More...
Q8N9H9	Uncharacterized protein C1orf127	DEG_SPOP_SBC_1	583:587	AHTSS	SPOP	0.9833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons