DegronMD

Uniprot ID: Q9Y6Y8

Source protein: SEC23-interacting protein

Source gene: SEC23IP

Class: DEG_SPOP_SBC_1

Location: 891:895

E3 ligase: SPOP

DEGRON score: 0.9839

ASA_SCORE: 80.96

COIL: 0.7566

CONS_SCORE: 0.3513

DSS_SCORE: 0.4097

HELIX: 0.2368

FCONS_SCORE: 0.993

RIG_SCORE: 0.7157

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T896I	TCGA-4J-AA1J	CESC	TCGA	AHTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55197	Protein AF-10	DEG_SPOP_SBC_1	299:303	AHTSS	SPOP	0.9984	More...
Q5TH69	Brefeldin A-inhibited guanine nucleotide-exchange protein 3	DEG_SPOP_SBC_1	280:284	AHTSS	SPOP	0.532	More...
Q9C0C7	Activating molecule in BECN1-regulated autophagy protein 1	DEG_SPOP_SBC_1	1201:1205	AHTSS	SPOP	0.9814	More...
Q9Y6Y8	SEC23-interacting protein	DEG_SPOP_SBC_1	891:895	AHTSS	SPOP	0.9839	More...
Q8N9H9	Uncharacterized protein C1orf127	DEG_SPOP_SBC_1	583:587	AHTSS	SPOP	0.9833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons