DegronMD - Q8N9H9(C1orf127)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R229T	TCGA-13-0884	OV	TCGA	TPPAGVPPA	DEG_SIAH_1	225:233	Mutation altering degron motif	0.7876
p.R229T	DO28913	OV	ICGC	TPPAGVPPA	DEG_SIAH_1	225:233	Mutation altering degron motif	0.7876
p.E307D	TCGA-19-5956	GBM	TCGA	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation rewiring degron network	0.2778
p.E307D	DO13863	GBM	ICGC	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation rewiring degron network	0.2778
p.K309E	TCGA-43-3920	LUSC	TCGA	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation altering degron motif	0.7022
p.K309E	DO26445	LUSC	ICGC	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation altering degron motif	0.7022
p.P222L	TCGA-63-A5MT	LUSC	TCGA	TPPAGVPPA	DEG_SIAH_1	225:233	Mutation rewiring degron network	0.25
p.P222L	DO219163	LUSC	ICGC	TPPAGVPPA	DEG_SIAH_1	225:233	Mutation rewiring degron network	0.25
p.P222L	SIDM00479	Esophageal Carcinoma	GDSC	TPPAGVPPA	DEG_SIAH_1	225:233	Mutation rewiring degron network	0.25
p.P222L	ACH-000679	Esophageal Cancer	CCLE	TPPAGVPPA	DEG_SIAH_1	225:233	Mutation rewiring degron network	0.25
p.A318V	TCGA-AA-A02E	COAD	TCGA	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation rewiring degron network	0.2222
p.A318V	SIDM01943	Colorectal Carcinoma	GDSC	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation rewiring degron network	0.2222
p.T546N	TCGA-B5-A11E	UCEC	TCGA	LLTPEAS	DEG_SCF_FBW7_1	550:556	Mutation rewiring degron network	0.2222
p.T546N	DO41644	UCEC	ICGC	LLTPEAS	DEG_SCF_FBW7_1	550:556	Mutation rewiring degron network	0.2222
p.G320R	TCGA-B5-A11Y	UCEC	TCGA	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation rewiring degron network	0.1667
p.G320R	DO40889	UCEC	ICGC	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation rewiring degron network	0.1667
p.G565D	TCGA-BF-A5EQ	SKCM	TCGA	LLTPEAS	DEG_SCF_FBW7_1	550:556	Mutation rewiring degron network	0.0833
p.G565D	DO219452	SKCM	ICGC	LLTPEAS	DEG_SCF_FBW7_1	550:556	Mutation rewiring degron network	0.0833
p.K555E	TCGA-BR-8363	STAD	TCGA	LLTPEAS	DEG_SCF_FBW7_1	550:556	Mutation altering degron motif	0.7022
p.K555E	DO47837	STAD	ICGC	LLTPEAS	DEG_SCF_FBW7_1	550:556	Mutation altering degron motif	0.7022
p.M304I	TCGA-D3-A1Q3	SKCM	TCGA	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation rewiring degron network	0.1944
p.M304I	DO47509	SKCM	ICGC	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation rewiring degron network	0.1944
p.T218I	TCGA-DA-A1HV	SKCM	TCGA	TPPAGVPPA	DEG_SIAH_1	225:233	Mutation rewiring degron network	0.1389
p.T218I	DO37659	SKCM	ICGC	TPPAGVPPA	DEG_SIAH_1	225:233	Mutation rewiring degron network	0.1389
p.Q589K	TCGA-E2-A1IN	BRCA	TCGA	AHTSS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.2778
p.Q589K	DO3134	BRCA	ICGC	AHTSS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.2778
p.E542K	TCGA-EB-A431	SKCM	TCGA	LLTPEAS	DEG_SCF_FBW7_1	550:556	Mutation rewiring degron network	0.1111
p.E542K	DO37671	SKCM	ICGC	LLTPEAS	DEG_SCF_FBW7_1	550:556	Mutation rewiring degron network	0.1111
p.P317S	TCGA-EB-A5UM	SKCM	TCGA	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation rewiring degron network	0.25
p.P317S	DO47282	SKCM	ICGC	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation rewiring degron network	0.25
p.E231K	TCGA-EE-A2GI	SKCM	TCGA	TPPAGVPPA	DEG_SIAH_1	225:233	Mutation altering degron motif	0.7022
p.E231K	DO37410	SKCM	ICGC	TPPAGVPPA	DEG_SIAH_1	225:233	Mutation altering degron motif	0.7022
p.V314F	TCGA-EJ-A6RC	PRAD	TCGA	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation altering degron motif	0.7068
p.V314F	DO219249	PRAD	ICGC	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation altering degron motif	0.7068
p.A318S	TCGA-EO-A22R	UCEC	TCGA	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation rewiring degron network	0.2222
p.A318S	DO42713	UCEC	ICGC	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation rewiring degron network	0.2222
p.P317L	TCGA-ER-A19F	SKCM	TCGA	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation rewiring degron network	0.25
p.P317L	DO37679	SKCM	ICGC	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation rewiring degron network	0.25
p.P317L	SIDM00646	Small Cell Lung Carcinoma	GDSC	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation rewiring degron network	0.25
p.P317L	ACH-000129	Lung Cancer	CCLE	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation rewiring degron network	0.25
p.L227F	TCGA-EY-A1G8	UCEC	TCGA	TPPAGVPPA	DEG_SIAH_1	225:233	Mutation altering degron motif	0.6981
p.L227F	DO43578	UCEC	ICGC	TPPAGVPPA	DEG_SIAH_1	225:233	Mutation altering degron motif	0.6981
p.L242P	TCGA-JY-A6FE	ESCA	TCGA	TPPAGVPPA	DEG_SIAH_1	225:233	Mutation rewiring degron network	0.0833
p.P553L	TCGA-WE-A8ZX	SKCM	TCGA	LLTPEAS	DEG_SCF_FBW7_1	550:556	Mutation altering degron motif	0.7582
p.P553L	DO51291	SKCM	ICGC	LLTPEAS	DEG_SCF_FBW7_1	550:556	Mutation altering degron motif	0.7582
p.V219I	DO233254	GACA	ICGC	TPPAGVPPA	DEG_SIAH_1	225:233	Mutation rewiring degron network	0.1667
p.P590S	DO220358	KICH	ICGC	AHTSS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.25
p.G558R	DO228241	LICA	ICGC	LLTPEAS	DEG_SCF_FBW7_1	550:556	Mutation rewiring degron network	0.2778
p.V324F	DO228929	LICA	ICGC	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation rewiring degron network	0.0556
p.D310G	DO232019	LICA	ICGC	PTPPAT	DEG_SCF_FBW7_1	309:314	Mutation altering degron motif	0.7198
p.Q224K	DO229028	LICA	ICGC	TPPAGVPPA	DEG_SIAH_1	225:233	Mutation rewiring degron network	0.3056
p.D552E	DO229009	LICA	ICGC	LLTPEAS	DEG_SCF_FBW7_1	550:556	Mutation altering degron motif	0.6758
p.P549T	DO229009	LICA	ICGC	LLTPEAS	DEG_SCF_FBW7_1	550:556	Mutation rewiring degron network	0.3056
p.S556F	DO52692	MALY	ICGC	LLTPEAS	DEG_SCF_FBW7_1	550:556	Mutation altering degron motif	0.7982
p.L226F	DO51521	PACA	ICGC	TPPAGVPPA	DEG_SIAH_1	225:233	Mutation altering degron motif	0.6981
p.P560L	SIDM00545	Melanoma	GDSC	LLTPEAS	DEG_SCF_FBW7_1	550:556	Mutation rewiring degron network	0.2222
p.P560L	ACH-000987	Skin Cancer	CCLE	LLTPEAS	DEG_SCF_FBW7_1	550:556	Mutation rewiring degron network	0.2222
p.Q551H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LLTPEAS	DEG_SCF_FBW7_1	550:556	Mutation altering degron motif	0.7582
p.Q551H	ACH-000953	Leukemia	CCLE	LLTPEAS	DEG_SCF_FBW7_1	550:556	Mutation altering degron motif	0.7582
p.E231D	SIDM00794	Other Solid Cancers	GDSC	TPPAGVPPA	DEG_SIAH_1	225:233	Mutation altering degron motif	0.6758
p.R596W	SIDM00217	Colorectal Carcinoma	GDSC	AHTSS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.0833
p.R596W	ACH-000999	Colon/Colorectal Cancer	CCLE	AHTSS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.0833
p.W230C	ACH-001540	Liposarcoma	CCLE	TPPAGVPPA	DEG_SIAH_1	225:233	Mutation altering degron motif	0.7

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C1orf127

UniProt ID: Q8N9H9

Entrez ID:

Protein name: Uncharacterized protein C1orf127

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C1orf127 in