DegronMD

Uniprot ID: Q8N9H9

Source protein: Uncharacterized protein C1orf127

Source gene: C1orf127

Class: DEG_SCF_FBW7_1

Location: 309:314

E3 ligase: FBXW7

DEGRON score: 0.8553

ASA_SCORE: 88

COIL: 0.9535

CONS_SCORE: 0.2203

DSS_SCORE: 0.7721

HELIX: 0.0145

FCONS_SCORE: 0.8594

RIG_SCORE: 0.5559

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E307D	TCGA-19-5956	GBM	TCGA	PTPPAT	DEG_SCF_FBW7_1	0.2778
p.E307D	DO13863	GBM	ICGC	PTPPAT	DEG_SCF_FBW7_1	0.2778
p.K309E	TCGA-43-3920	LUSC	TCGA	PTPPAT	DEG_SCF_FBW7_1	0.7022
p.K309E	DO26445	LUSC	ICGC	PTPPAT	DEG_SCF_FBW7_1	0.7022
p.A318V	TCGA-AA-A02E	COAD	TCGA	PTPPAT	DEG_SCF_FBW7_1	0.2222
p.A318V	SIDM01943	Colorectal Carcinoma	GDSC	PTPPAT	DEG_SCF_FBW7_1	0.2222
p.G320R	TCGA-B5-A11Y	UCEC	TCGA	PTPPAT	DEG_SCF_FBW7_1	0.1667
p.G320R	DO40889	UCEC	ICGC	PTPPAT	DEG_SCF_FBW7_1	0.1667
p.M304I	TCGA-D3-A1Q3	SKCM	TCGA	PTPPAT	DEG_SCF_FBW7_1	0.1944
p.M304I	DO47509	SKCM	ICGC	PTPPAT	DEG_SCF_FBW7_1	0.1944
p.P317S	TCGA-EB-A5UM	SKCM	TCGA	PTPPAT	DEG_SCF_FBW7_1	0.25
p.P317S	DO47282	SKCM	ICGC	PTPPAT	DEG_SCF_FBW7_1	0.25
p.V314F	TCGA-EJ-A6RC	PRAD	TCGA	PTPPAT	DEG_SCF_FBW7_1	0.7068
p.V314F	DO219249	PRAD	ICGC	PTPPAT	DEG_SCF_FBW7_1	0.7068
p.A318S	TCGA-EO-A22R	UCEC	TCGA	PTPPAT	DEG_SCF_FBW7_1	0.2222
p.A318S	DO42713	UCEC	ICGC	PTPPAT	DEG_SCF_FBW7_1	0.2222
p.P317L	TCGA-ER-A19F	SKCM	TCGA	PTPPAT	DEG_SCF_FBW7_1	0.25
p.P317L	DO37679	SKCM	ICGC	PTPPAT	DEG_SCF_FBW7_1	0.25
p.P317L	SIDM00646	Small Cell Lung Carcinoma	GDSC	PTPPAT	DEG_SCF_FBW7_1	0.25
p.P317L	ACH-000129	Lung Cancer	CCLE	PTPPAT	DEG_SCF_FBW7_1	0.25
p.V324F	DO228929	LICA	ICGC	PTPPAT	DEG_SCF_FBW7_1	0.0556
p.D310G	DO232019	LICA	ICGC	PTPPAT	DEG_SCF_FBW7_1	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N9H9	Uncharacterized protein C1orf127	DEG_SCF_FBW7_1	309:314	PTPPAT	FBXW7	0.8553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons