DegronMD

Uniprot ID: Q8N9H9

Source protein: Uncharacterized protein C1orf127

Source gene: C1orf127

Class: DEG_SCF_FBW7_1

Location: 550:556

E3 ligase: FBXW7

DEGRON score: 0.9737

ASA_SCORE: 89.8286

COIL: 0.9286

CONS_SCORE: 0.4457

DSS_SCORE: 0.5691

HELIX: 0.0541

FCONS_SCORE: 1.1812

RIG_SCORE: 0.6829

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T546N	TCGA-B5-A11E	UCEC	TCGA	LLTPEAS	DEG_SCF_FBW7_1	0.2222
p.T546N	DO41644	UCEC	ICGC	LLTPEAS	DEG_SCF_FBW7_1	0.2222
p.G565D	TCGA-BF-A5EQ	SKCM	TCGA	LLTPEAS	DEG_SCF_FBW7_1	0.0833
p.G565D	DO219452	SKCM	ICGC	LLTPEAS	DEG_SCF_FBW7_1	0.0833
p.K555E	TCGA-BR-8363	STAD	TCGA	LLTPEAS	DEG_SCF_FBW7_1	0.7022
p.K555E	DO47837	STAD	ICGC	LLTPEAS	DEG_SCF_FBW7_1	0.7022
p.E542K	TCGA-EB-A431	SKCM	TCGA	LLTPEAS	DEG_SCF_FBW7_1	0.1111
p.E542K	DO37671	SKCM	ICGC	LLTPEAS	DEG_SCF_FBW7_1	0.1111
p.P553L	TCGA-WE-A8ZX	SKCM	TCGA	LLTPEAS	DEG_SCF_FBW7_1	0.7582
p.P553L	DO51291	SKCM	ICGC	LLTPEAS	DEG_SCF_FBW7_1	0.7582
p.G558R	DO228241	LICA	ICGC	LLTPEAS	DEG_SCF_FBW7_1	0.2778
p.D552E	DO229009	LICA	ICGC	LLTPEAS	DEG_SCF_FBW7_1	0.6758
p.P549T	DO229009	LICA	ICGC	LLTPEAS	DEG_SCF_FBW7_1	0.3056
p.S556F	DO52692	MALY	ICGC	LLTPEAS	DEG_SCF_FBW7_1	0.7982
p.P560L	SIDM00545	Melanoma	GDSC	LLTPEAS	DEG_SCF_FBW7_1	0.2222
p.P560L	ACH-000987	Skin Cancer	CCLE	LLTPEAS	DEG_SCF_FBW7_1	0.2222
p.Q551H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LLTPEAS	DEG_SCF_FBW7_1	0.7582
p.Q551H	ACH-000953	Leukemia	CCLE	LLTPEAS	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUM7	Neuronal PAS domain-containing protein 4	DEG_SCF_FBW7_1	609:615	LLTPEAS	FBXW7	0.9973	More...
Q8N9H9	Uncharacterized protein C1orf127	DEG_SCF_FBW7_1	550:556	LLTPEAS	FBXW7	0.9737	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons