DegronMD

Uniprot ID: Q8IUM7

Source protein: Neuronal PAS domain-containing protein 4

Source gene: NPAS4

Class: DEG_SCF_FBW7_1

Location: 609:615

E3 ligase: FBXW7

DEGRON score: 0.9973

ASA_SCORE: 68.2714

COIL: 0.9284

CONS_SCORE: 0.588

DSS_SCORE: 0.3617

HELIX: 0.0326

FCONS_SCORE: 1.2305

RIG_SCORE: 0.7185

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P616L	TCGA-EE-A180	SKCM	TCGA	LLTPEAS	DEG_SCF_FBW7_1	0.3056
p.P616L	DO47537	SKCM	ICGC	LLTPEAS	DEG_SCF_FBW7_1	0.3056
p.L609M	DO234199	ESAD	ICGC	LLTPEAS	DEG_SCF_FBW7_1	0.5999
p.P612T	ACH-000278	Ovarian Cancer	CCLE	LLTPEAS	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUM7	Neuronal PAS domain-containing protein 4	DEG_SCF_FBW7_1	609:615	LLTPEAS	FBXW7	0.9973	More...
Q8N9H9	Uncharacterized protein C1orf127	DEG_SCF_FBW7_1	550:556	LLTPEAS	FBXW7	0.9737	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons