DegronMD - Q8IUM7(NPAS4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P720L	TCGA-17-Z042	LUAD	TCGA	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation altering degron motif	0.7582
p.S599F	TCGA-18-3409	LUSC	TCGA	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation altering degron motif	0.7982
p.S599F	DO26444	LUSC	ICGC	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation altering degron motif	0.7982
p.T708M	TCGA-26-1439	GBM	TCGA	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.0833
p.T708M	TCGA-IR-A3LK	CESC	TCGA	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.0833
p.T708M	DO44299	CESC	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.0833
p.T708M	DO234392	ESAD	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.0833
p.T708M	DO233731	GACA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.0833
p.T708M	DO13803	GBM	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.0833
p.E724Q	TCGA-2F-A9KT	BLCA	TCGA	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.3056
p.E724Q	DO51863	BLCA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.3056
p.A517S	TCGA-37-A5EL	LUSC	TCGA	PCTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0556
p.A517S	DO223718	LUSC	ICGC	PCTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0556
p.Q500R	TCGA-49-AARN	LUAD	TCGA	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation rewiring degron network	0.3056
p.Q500R	TCGA-49-AARN	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.Q500R	DO218923	LUAD	ICGC	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation rewiring degron network	0.3056
p.Q500R	DO218923	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.T505I	TCGA-50-5931	LUAD	TCGA	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation altering degron motif	0.5966
p.T505I	TCGA-50-5931	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	503:507	Mutation altering degron motif	0.7078
p.T505I	DO24980	LUAD	ICGC	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation altering degron motif	0.5966
p.T505I	DO24980	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	503:507	Mutation altering degron motif	0.7078
p.G432V	TCGA-61-1740	OV	TCGA	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation rewiring degron network	0.1944
p.G432V	DO27981	OV	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation rewiring degron network	0.1944
p.A592G	TCGA-66-2756	LUSC	TCGA	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.1389
p.A592G	DO27128	LUSC	ICGC	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.1389
p.E498V	TCGA-77-7337	LUSC	TCGA	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation rewiring degron network	0.25
p.E498V	TCGA-77-7337	LUSC	TCGA	PCTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1944
p.E498V	DO27445	LUSC	ICGC	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation rewiring degron network	0.25
p.E498V	DO27445	LUSC	ICGC	PCTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1944
p.A435D	TCGA-86-7701	LUAD	TCGA	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation rewiring degron network	0.1111
p.A435D	DO24441	LUAD	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation rewiring degron network	0.1111
p.C434W	TCGA-86-8073	LUAD	TCGA	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation rewiring degron network	0.1389
p.C434W	DO23624	LUAD	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation rewiring degron network	0.1389
p.P545H	TCGA-99-8032	LUAD	TCGA	LTPPST	DEG_SCF_FBW7_1	531:536	Mutation rewiring degron network	0.0833
p.P545H	DO23765	LUAD	ICGC	LTPPST	DEG_SCF_FBW7_1	531:536	Mutation rewiring degron network	0.0833
p.T516I	TCGA-A5-A0G2	UCEC	TCGA	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation rewiring degron network	0.0556
p.T516I	TCGA-A5-A0G2	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0833
p.T516I	DO41235	UCEC	ICGC	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation rewiring degron network	0.0556
p.T516I	DO41235	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0833
p.S544N	TCGA-AM-5821	COAD	TCGA	LTPPST	DEG_SCF_FBW7_1	531:536	Mutation rewiring degron network	0.1111
p.S544N	DO8240	COAD	ICGC	LTPPST	DEG_SCF_FBW7_1	531:536	Mutation rewiring degron network	0.1111
p.S544N	SIDM00499	Prostate Carcinoma	GDSC	LTPPST	DEG_SCF_FBW7_1	531:536	Mutation rewiring degron network	0.1111
p.S544N	ACH-000956	Prostate Cancer	CCLE	LTPPST	DEG_SCF_FBW7_1	531:536	Mutation rewiring degron network	0.1111
p.S544N	22RV1	prostate	COSMIC	LTPPST	DEG_SCF_FBW7_1	531:536	Mutation rewiring degron network	0.1111
p.R595W	TCGA-AO-A0JF	BRCA	TCGA	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.2222
p.R595W	TCGA-CJ-4640	KIRC	TCGA	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.2222
p.R595W	TCGA-DM-A0XF	COAD	TCGA	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.2222
p.R595W	TCGA-E9-A5FK	BRCA	TCGA	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.2222
p.R595W	DO44192	BRCA	ICGC	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.2222
p.R595W	DO2533	BRCA	ICGC	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.2222
p.R595W	DO9258	COAD	ICGC	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.2222
p.R595W	DO16202	KIRC	ICGC	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.2222
p.T423I	TCGA-AP-A056	UCEC	TCGA	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation altering degron motif	0.7078
p.T423I	DO43971	UCEC	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation altering degron motif	0.7078
p.P597S	TCGA-AP-A0LM	UCEC	TCGA	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.2778
p.P597S	DO222655	BTCA	ICGC	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.2778
p.P597S	DO43306	UCEC	ICGC	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.2778
p.E707D	TCGA-AP-A0LM	UCEC	TCGA	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.0556
p.E707D	DO43306	UCEC	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.0556
p.D730N	TCGA-AX-A2HH	UCEC	TCGA	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.1389
p.D730N	TCGA-FS-A1ZZ	SKCM	TCGA	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.1389
p.D730N	DO37412	SKCM	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.1389
p.D730N	DO43057	UCEC	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.1389
p.H528Y	TCGA-BF-A1PX	SKCM	TCGA	LTPPST	DEG_SCF_FBW7_1	531:536	Mutation rewiring degron network	0.25
p.H528Y	DO51236	SKCM	ICGC	LTPPST	DEG_SCF_FBW7_1	531:536	Mutation rewiring degron network	0.25
p.P410S	TCGA-BR-7704	STAD	TCGA	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation rewiring degron network	0.0556
p.P410S	DO233869	GACA	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation rewiring degron network	0.0556
p.P410S	DO38360	STAD	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation rewiring degron network	0.0556
p.E711D	TCGA-BR-8680	STAD	TCGA	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.1667
p.E711D	DO47769	STAD	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.1667
p.R595Q	TCGA-CN-A63U	HNSC	TCGA	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.2222
p.R595Q	DO227549	COCA	ICGC	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.2222
p.R595Q	DO44454	HNSC	ICGC	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.2222
p.S452F	TCGA-D3-A8GM	SKCM	TCGA	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation altering degron motif	0.6871
p.S452F	DO50288	SKCM	ICGC	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation altering degron motif	0.6871
p.S452F	SIDM00140	Melanoma	GDSC	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation altering degron motif	0.6871
p.S452F	ACH-000968	Skin Cancer	CCLE	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation altering degron motif	0.6871
p.S452F	COLO-792	skin	COSMIC	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation altering degron motif	0.6871
p.P533S	TCGA-DA-A1I0	SKCM	TCGA	LTPPST	DEG_SCF_FBW7_1	531:536	Mutation altering degron motif	0.6752
p.P533S	TCGA-FS-A1ZC	SKCM	TCGA	LTPPST	DEG_SCF_FBW7_1	531:536	Mutation altering degron motif	0.6752
p.P533S	DO37719	SKCM	ICGC	LTPPST	DEG_SCF_FBW7_1	531:536	Mutation altering degron motif	0.6752
p.P533S	DO37487	SKCM	ICGC	LTPPST	DEG_SCF_FBW7_1	531:536	Mutation altering degron motif	0.6752
p.L455F	TCGA-DA-A3F5	SKCM	TCGA	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation rewiring degron network	0.3056
p.L455F	DO37435	SKCM	ICGC	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation rewiring degron network	0.3056
p.E725K	TCGA-DA-A3F8	SKCM	TCGA	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.2778
p.E725K	TCGA-EE-A2MJ	SKCM	TCGA	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.2778
p.E725K	DO222395	MELA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.2778
p.E725K	DO222875	MELA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.2778
p.E725K	DO37418	SKCM	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.2778
p.E725K	DO38099	SKCM	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.2778
p.E725K	SIDM01086	B-Lymphoblastic Leukemia	GDSC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.2778
p.E725K	ACH-000874	Leukemia	CCLE	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.2778
p.E725K	RS4-11	haematopoietic and lymphoid tissue	COSMIC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.2778
p.E724K	TCGA-DS-A1OC	CESC	TCGA	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.3056
p.E724K	DO6329	CESC	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.3056
p.E498Q	TCGA-E2-A1LG	BRCA	TCGA	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation rewiring degron network	0.25
p.E498Q	TCGA-E2-A1LG	BRCA	TCGA	PCTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1944
p.E498Q	DO4018	BRCA	ICGC	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation rewiring degron network	0.25
p.E498Q	DO4018	BRCA	ICGC	PCTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1944
p.T450I	TCGA-E6-A1LX	UCEC	TCGA	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation altering degron motif	0.7078
p.T450I	TCGA-FW-A3R5	SKCM	TCGA	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation altering degron motif	0.7078
p.T450I	DO37406	SKCM	ICGC	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation altering degron motif	0.7078
p.T450I	DO41020	UCEC	ICGC	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation altering degron motif	0.7078
p.T450I	SIDM00447	B-Lymphoblastic Leukemia	GDSC	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation altering degron motif	0.7078
p.T450I	ACH-000960	Leukemia	CCLE	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation altering degron motif	0.7078
p.T450I	REH	haematopoietic and lymphoid tissue	COSMIC	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation altering degron motif	0.7078
p.D721Y	TCGA-E7-A85H	BLCA	TCGA	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation altering degron motif	0.6214
p.D721Y	DO219018	BLCA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation altering degron motif	0.6214
p.P606A	TCGA-EB-A4IS	SKCM	TCGA	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation altering degron motif	0.7503
p.P606A	DO47281	SKCM	ICGC	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation altering degron motif	0.7503
p.P616L	TCGA-EE-A180	SKCM	TCGA	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.1389
p.P616L	TCGA-EE-A180	SKCM	TCGA	LLTPEAS	DEG_SCF_FBW7_1	609:615	Mutation rewiring degron network	0.3056
p.P616L	DO47537	SKCM	ICGC	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.1389
p.P616L	DO47537	SKCM	ICGC	LLTPEAS	DEG_SCF_FBW7_1	609:615	Mutation rewiring degron network	0.3056
p.P503S	TCGA-EE-A2MR	SKCM	TCGA	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation altering degron motif	0.6752
p.P503S	TCGA-EE-A2MR	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	503:507	Mutation altering degron motif	0.6752
p.P503S	DO37819	SKCM	ICGC	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation altering degron motif	0.6752
p.P503S	DO37819	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	503:507	Mutation altering degron motif	0.6752
p.P503L	TCGA-EE-A2MR	SKCM	TCGA	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation altering degron motif	0.7582
p.P503L	TCGA-EE-A2MR	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	503:507	Mutation altering degron motif	0.7582
p.P503L	DO37819	SKCM	ICGC	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation altering degron motif	0.7582
p.P503L	DO37819	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	503:507	Mutation altering degron motif	0.7582
p.D419N	TCGA-FS-A1ZK	SKCM	TCGA	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation rewiring degron network	0.3056
p.D419N	DO229462	SKCA	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation rewiring degron network	0.3056
p.D419N	DO37474	SKCM	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation rewiring degron network	0.3056
p.D716N	TCGA-FW-A3R5	SKCM	TCGA	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.3056
p.D716N	DO37406	SKCM	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.3056
p.P425L	TCGA-GF-A6C9	SKCM	TCGA	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation altering degron motif	0.6471
p.P425L	DO51254	SKCM	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation altering degron motif	0.6471
p.P722S	TCGA-GF-A6C9	SKCM	TCGA	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation altering degron motif	0.5641
p.P722S	DO51254	SKCM	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation altering degron motif	0.5641
p.G729E	TCGA-GN-A26C	SKCM	TCGA	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.1667
p.G729E	DO37782	SKCM	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.1667
p.F438L	TCGA-VS-A8Q8	CESC	TCGA	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation rewiring degron network	0.0556
p.F438L	DO51625	CESC	ICGC	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation rewiring degron network	0.0556
p.P424S	TCGA-W3-A824	SKCM	TCGA	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation altering degron motif	0.6752
p.P424S	DO51271	SKCM	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation altering degron motif	0.6752
p.P424L	TCGA-W3-A824	SKCM	TCGA	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation altering degron motif	0.7582
p.P424L	DO51271	SKCM	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation altering degron motif	0.7582
p.P720Q	DO225374	BRCA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation altering degron motif	0.7035
p.T427M	DO224897	BRCA	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation altering degron motif	0.7423
p.D499H	DO1094	BRCA	ICGC	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation rewiring degron network	0.2778
p.D499H	DO1094	BRCA	ICGC	PCTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.2222
p.Q539E	DO229013	COCA	ICGC	LTPPST	DEG_SCF_FBW7_1	531:536	Mutation rewiring degron network	0.25
p.L609M	DO234199	ESAD	ICGC	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation altering degron motif	0.5999
p.L609M	DO234199	ESAD	ICGC	LLTPEAS	DEG_SCF_FBW7_1	609:615	Mutation altering degron motif	0.5999
p.V710M	DO48224	ESCA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.1389
p.D543E	DO233259	GACA	ICGC	LTPPST	DEG_SCF_FBW7_1	531:536	Mutation rewiring degron network	0.1389
p.T454A	DO233663	GACA	ICGC	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation altering degron motif	0.7139
p.L717P	DO233917	GACA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation altering degron motif	0.6471
p.S453I	DO229028	LICA	ICGC	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation altering degron motif	0.623
p.V710L	DO229038	LICA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.1389
p.P443L	DO220893	MELA	ICGC	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation rewiring degron network	0.1944
p.P461L	DO222662	MELA	ICGC	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation rewiring degron network	0.1389
p.P451L	DO222843	MELA	ICGC	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation altering degron motif	0.7582
p.P731S	DO222843	MELA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation rewiring degron network	0.1111
p.S453C	DO27887	ORCA	ICGC	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation altering degron motif	0.643
p.L420I	DO233550	PRAD	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	420:427	Mutation altering degron motif	0.6063
p.P509S	SIDM00545	Melanoma	GDSC	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation rewiring degron network	0.25
p.P509S	SIDM00545	Melanoma	GDSC	PCTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.2778
p.P509S	ACH-000987	Skin Cancer	CCLE	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation rewiring degron network	0.25
p.P509S	ACH-000987	Skin Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.2778
p.P509S	Mewo	skin	COSMIC	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation rewiring degron network	0.25
p.P509S	Mewo	skin	COSMIC	PCTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.2778
p.V600M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation altering degron motif	0.6097
p.V600M	ACH-002256	Leukemia	CCLE	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation altering degron motif	0.6097
p.V600M	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation altering degron motif	0.6097
p.S723N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation altering degron motif	0.7069
p.S723N	ACH-002256	Leukemia	CCLE	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation altering degron motif	0.7069
p.S723N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation altering degron motif	0.7069
p.S493L	SIDM01106	Melanoma	GDSC	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation rewiring degron network	0.1111
p.S493L	SIDM01106	Melanoma	GDSC	PCTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0556
p.S493L	ACH-000822	Skin Cancer	CCLE	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation rewiring degron network	0.1111
p.S493L	ACH-000822	Skin Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0556
p.S493L	SK-MEL-24	skin	COSMIC	LTPCTS	DEG_SCF_FBW7_1	501:506	Mutation rewiring degron network	0.1111
p.S493L	SK-MEL-24	skin	COSMIC	PCTST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0556
p.E607K	SIDM00892	Breast Carcinoma	GDSC	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation altering degron motif	0.7022
p.E607K	ACH-000818	Breast Cancer	CCLE	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation altering degron motif	0.7022
p.E607K	BT-483	breast	COSMIC	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation altering degron motif	0.7022
p.A537T	SIDM00126	Melanoma	GDSC	LTPPST	DEG_SCF_FBW7_1	531:536	Mutation rewiring degron network	0.3056
p.A537T	ACH-002147	Skin Cancer	CCLE	LTPPST	DEG_SCF_FBW7_1	531:536	Mutation rewiring degron network	0.3056
p.A537T	K2	skin	COSMIC	LTPPST	DEG_SCF_FBW7_1	531:536	Mutation rewiring degron network	0.3056
p.Q593K	SIDM00622	Glioblastoma	GDSC	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.1667
p.Q593K	ACH-002224	Brain Cancer	CCLE	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.1667
p.Q593K	D-247MG	central nervous system	COSMIC	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.1667
p.P612T	ACH-000278	Ovarian Cancer	CCLE	LLTPEAS	DEG_SCF_FBW7_1	609:615	Mutation altering degron motif	0.7031
p.P449H	ACH-000901	Lung Cancer	CCLE	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation altering degron motif	0.6583
p.L598P	ACH-000975	Lung Cancer	CCLE	SVDVPLVPEGL	DEG_COP1_1	599:609	Mutation rewiring degron network	0.3056
p.S718Y	ACH-000985	Colon/Colorectal Cancer	CCLE	LSTPDPS	DEG_SCF_FBW7_1	717:723	Mutation altering degron motif	0.6009
p.E442Q	ACH-001513	Cervical Cancer	CCLE	LPTPSST	DEG_SCF_FBW7_1	448:454	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NPAS4

UniProt ID: Q8IUM7

Entrez ID: 266743

Protein name: Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (Class E basic helix-loop-helix protein 79) (bHLHe79) (HLH-PAS transcription factor NXF) (PAS domain-containing protein 10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NPAS4 in