DegronMD

Uniprot ID: Q8IUM7

Source protein: Neuronal PAS domain-containing protein 4

Source gene: NPAS4

Class: DEG_SCF_FBW7_1

Location: 717:723

E3 ligase: FBXW7

DEGRON score: 0.9511

ASA_SCORE: 65.2714

COIL: 0.9086

CONS_SCORE: 0.4365

DSS_SCORE: 0.7237

HELIX: 0.0627

FCONS_SCORE: 1.0518

RIG_SCORE: 0.6519

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P720L	TCGA-17-Z042	LUAD	TCGA	LSTPDPS	DEG_SCF_FBW7_1	0.7582
p.T708M	TCGA-26-1439	GBM	TCGA	LSTPDPS	DEG_SCF_FBW7_1	0.0833
p.T708M	TCGA-IR-A3LK	CESC	TCGA	LSTPDPS	DEG_SCF_FBW7_1	0.0833
p.T708M	DO44299	CESC	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.0833
p.T708M	DO234392	ESAD	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.0833
p.T708M	DO233731	GACA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.0833
p.T708M	DO13803	GBM	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.0833
p.E724Q	TCGA-2F-A9KT	BLCA	TCGA	LSTPDPS	DEG_SCF_FBW7_1	0.3056
p.E724Q	DO51863	BLCA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.3056
p.E707D	TCGA-AP-A0LM	UCEC	TCGA	LSTPDPS	DEG_SCF_FBW7_1	0.0556
p.E707D	DO43306	UCEC	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.0556
p.D730N	TCGA-AX-A2HH	UCEC	TCGA	LSTPDPS	DEG_SCF_FBW7_1	0.1389
p.D730N	TCGA-FS-A1ZZ	SKCM	TCGA	LSTPDPS	DEG_SCF_FBW7_1	0.1389
p.D730N	DO37412	SKCM	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.1389
p.D730N	DO43057	UCEC	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.1389
p.E711D	TCGA-BR-8680	STAD	TCGA	LSTPDPS	DEG_SCF_FBW7_1	0.1667
p.E711D	DO47769	STAD	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.1667
p.E725K	TCGA-DA-A3F8	SKCM	TCGA	LSTPDPS	DEG_SCF_FBW7_1	0.2778
p.E725K	TCGA-EE-A2MJ	SKCM	TCGA	LSTPDPS	DEG_SCF_FBW7_1	0.2778
p.E725K	DO222395	MELA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.2778
p.E725K	DO222875	MELA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.2778
p.E725K	DO37418	SKCM	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.2778
p.E725K	DO38099	SKCM	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.2778
p.E725K	SIDM01086	B-Lymphoblastic Leukemia	GDSC	LSTPDPS	DEG_SCF_FBW7_1	0.2778
p.E725K	ACH-000874	Leukemia	CCLE	LSTPDPS	DEG_SCF_FBW7_1	0.2778
p.E725K	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPDPS	DEG_SCF_FBW7_1	0.2778
p.E724K	TCGA-DS-A1OC	CESC	TCGA	LSTPDPS	DEG_SCF_FBW7_1	0.3056
p.E724K	DO6329	CESC	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.3056
p.D721Y	TCGA-E7-A85H	BLCA	TCGA	LSTPDPS	DEG_SCF_FBW7_1	0.6214
p.D721Y	DO219018	BLCA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.6214
p.D716N	TCGA-FW-A3R5	SKCM	TCGA	LSTPDPS	DEG_SCF_FBW7_1	0.3056
p.D716N	DO37406	SKCM	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.3056
p.P722S	TCGA-GF-A6C9	SKCM	TCGA	LSTPDPS	DEG_SCF_FBW7_1	0.5641
p.P722S	DO51254	SKCM	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.5641
p.G729E	TCGA-GN-A26C	SKCM	TCGA	LSTPDPS	DEG_SCF_FBW7_1	0.1667
p.G729E	DO37782	SKCM	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.1667
p.P720Q	DO225374	BRCA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.7035
p.V710M	DO48224	ESCA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.1389
p.L717P	DO233917	GACA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.6471
p.V710L	DO229038	LICA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.1389
p.P731S	DO222843	MELA	ICGC	LSTPDPS	DEG_SCF_FBW7_1	0.1111
p.S723N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LSTPDPS	DEG_SCF_FBW7_1	0.7069
p.S723N	ACH-002256	Leukemia	CCLE	LSTPDPS	DEG_SCF_FBW7_1	0.7069
p.S723N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPDPS	DEG_SCF_FBW7_1	0.7069
p.S718Y	ACH-000985	Colon/Colorectal Cancer	CCLE	LSTPDPS	DEG_SCF_FBW7_1	0.6009

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSTPDPS

Degron related mutations and impact score

Drug responses associated with NPAS4 mutations

All proteins holding degron of LSTPDPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUM7	Neuronal PAS domain-containing protein 4	DEG_SCF_FBW7_1	717:723	LSTPDPS	FBXW7	0.9511	More...