DegronMD

Uniprot ID: Q8IUM7

Source protein: Neuronal PAS domain-containing protein 4

Source gene: NPAS4

Class: DEG_SPOP_SBC_1

Location: 503:507

E3 ligase: SPOP

DEGRON score: 0.8959

ASA_SCORE: 60.3

COIL: 0.9084

CONS_SCORE: 0.3304

DSS_SCORE: 0.549

HELIX: 0.0512

FCONS_SCORE: 1.0948

RIG_SCORE: 0.7423

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A517S	TCGA-37-A5EL	LUSC	TCGA	PCTST	DEG_SPOP_SBC_1	0.0556
p.A517S	DO223718	LUSC	ICGC	PCTST	DEG_SPOP_SBC_1	0.0556
p.Q500R	TCGA-49-AARN	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.25
p.Q500R	DO218923	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.25
p.T505I	TCGA-50-5931	LUAD	TCGA	PCTST	DEG_SPOP_SBC_1	0.7078
p.T505I	DO24980	LUAD	ICGC	PCTST	DEG_SPOP_SBC_1	0.7078
p.E498V	TCGA-77-7337	LUSC	TCGA	PCTST	DEG_SPOP_SBC_1	0.1944
p.E498V	DO27445	LUSC	ICGC	PCTST	DEG_SPOP_SBC_1	0.1944
p.T516I	TCGA-A5-A0G2	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	0.0833
p.T516I	DO41235	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	0.0833
p.E498Q	TCGA-E2-A1LG	BRCA	TCGA	PCTST	DEG_SPOP_SBC_1	0.1944
p.E498Q	DO4018	BRCA	ICGC	PCTST	DEG_SPOP_SBC_1	0.1944
p.P503S	TCGA-EE-A2MR	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	0.6752
p.P503S	DO37819	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	0.6752
p.P503L	TCGA-EE-A2MR	SKCM	TCGA	PCTST	DEG_SPOP_SBC_1	0.7582
p.P503L	DO37819	SKCM	ICGC	PCTST	DEG_SPOP_SBC_1	0.7582
p.D499H	DO1094	BRCA	ICGC	PCTST	DEG_SPOP_SBC_1	0.2222
p.P509S	SIDM00545	Melanoma	GDSC	PCTST	DEG_SPOP_SBC_1	0.2778
p.P509S	ACH-000987	Skin Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	0.2778
p.P509S	Mewo	skin	COSMIC	PCTST	DEG_SPOP_SBC_1	0.2778
p.S493L	SIDM01106	Melanoma	GDSC	PCTST	DEG_SPOP_SBC_1	0.0556
p.S493L	ACH-000822	Skin Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	0.0556
p.S493L	SK-MEL-24	skin	COSMIC	PCTST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14917	Protocadherin-17	DEG_SPOP_SBC_1	1046:1050	PCTST	SPOP	0.9985	More...
Q01851	POU domain, class 4, transcription factor 1	DEG_SPOP_SBC_1	89:93	PCTST	SPOP	0.8746	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	923:927	PCTST	SPOP	0.7275	More...
Q15319	POU domain, class 4, transcription factor 3	DEG_SPOP_SBC_1	87:91	PCTST	SPOP	0.9732	More...
Q6ZN17	Protein lin-28 homolog B	DEG_SPOP_SBC_1	186:190	PCTST	SPOP	0.9507	More...
Q8IUM7	Neuronal PAS domain-containing protein 4	DEG_SPOP_SBC_1	503:507	PCTST	SPOP	0.8959	More...
Q8WW38	Zinc finger protein ZFPM2	DEG_SPOP_SBC_1	769:773	PCTST	SPOP	0.5014	More...
Q9Y2X3	Nucleolar protein 58	DEG_SPOP_SBC_1	506:510	PCTST	SPOP	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons