DegronMD - Q15319(POU4F3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S98P	TCGA-A5-A0G1	UCEC	TCGA	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1389
p.S98P	DO42472	UCEC	ICGC	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1389
p.P96S	TCGA-AM-5821	COAD	TCGA	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1944
p.P96S	DO8240	COAD	ICGC	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1944
p.A78T	TCGA-EI-6917	READ	TCGA	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.0833
p.A78T	DO222946	BTCA	ICGC	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.0833
p.A78T	DO36881	READ	ICGC	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.0833
p.A78T	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.0833
p.A78T	ACH-000938	Leukemia	CCLE	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.0833
p.A78T	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.0833
p.S92L	TCGA-EK-A2RK	CESC	TCGA	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.3056
p.S92L	DO49952	CESC	ICGC	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.3056
p.S92L	DO227981	COCA	ICGC	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.3056
p.S92L	DO50679	ORCA	ICGC	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.3056
p.S92L	DO218906	SKCA	ICGC	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.3056
p.S84C	TCGA-VQ-A8P3	STAD	TCGA	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.25
p.S84C	DO51762	STAD	ICGC	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.25
p.S93Y	TCGA-VS-A9UL	CESC	TCGA	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2778
p.S93Y	DO51643	CESC	ICGC	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2778
p.T82N	TCGA-XE-AAOC	TGCT	TCGA	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1944
p.S85N	SIDM00781	Colorectal Carcinoma	GDSC	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2778
p.S85N	SIDM00780	Colorectal Carcinoma	GDSC	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2778
p.S85N	ACH-000967	Colon/Colorectal Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2778
p.S85N	ACH-001199	Colon/Colorectal Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2778
p.S85N	SNU-C2B	large intestine	COSMIC	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2778
p.V95M	SIDM00660	Colorectal Carcinoma	GDSC	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2222
p.V95M	ACH-000985	Colon/Colorectal Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2222
p.V95M	ACH-001329	Brain Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2222
p.V95M	LS-411N	large intestine	COSMIC	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2222
p.M83I	SIDM01088	Endometrial Carcinoma	GDSC	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2222
p.M83I	ACH-000965	Endometrial/Uterine Cancer	CCLE	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2222
p.M83I	RL95-2	endometrium	COSMIC	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2222
p.S84N	ACH-001991	Primary	CCLE	PCTST	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.25

Kaplan plot for POU4F3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POU4F3

UniProt ID: Q15319

Entrez ID: 5459

Protein name: POU domain, class 4, transcription factor 3 (Brain-specific homeobox/POU domain protein 3C) (Brain-3C) (Brn-3C)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for POU4F3 in